Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.[2]
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Wang Y, Amagai M, Minoshima S, et al. (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics. 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID8034325.
Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID8143788.
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Marsden MD, Collins JE, Greenwood MD, et al. (1997). "Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2)". Gene. 186 (2): 237–47. doi:10.1016/S0378-1119(96)00715-9. PMID9074502.
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Czerwenka KF, Manavi M, Hosmann J, et al. (2001). "Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue". Cancer Detect. Prev. 25 (3): 268–79. PMID11425269.
Weiske J, Schöneberg T, Schröder W, et al. (2001). "The fate of desmosomal proteins in apoptotic cells". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID11500511.
Andl CD, Stanley JR (2001). "Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes". J. Invest. Dermatol. 117 (5): 1068–74. doi:10.1046/j.0022-202x.2001.01528.x. PMID11710914.
Hanakawa Y, Amagai M, Shirakata Y, et al. (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID12485422.
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