De Quervain's thyroiditis medical therapy

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De Quervain's thyroiditis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating De Quervain's thyroiditis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary prevention

Secondary prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The mainstay of therapy for de Quervain's thyroiditis is aspirin or non-steroidal anti-inflammatory drugs for pain control. Beta-adrenergic blockers are recommended for the patients who develop thyrotoxic symptoms. Corticosteroids are usually used in severely ill patients.

Medical Therapy

The drugs used in the treatment of De Quervain's thyroiditis are:[1][2][3]

  1. Asprin or NSAIDs:
    • Aspirin and non-steroidal anti-inflammatory drugs are used for pain control.
  2. Beta adrenergic blockers:
    • Beta-adrenergic blockers such as propranolol and atenolol are used for controlling thyrotoxic symptoms.
  3. Corticosteroids:
    • Corticosteroids usually show a dramatic response in severely ill patients within 24-48 hours.
  4. Levothyroxine:
    • It is required if the patient develops hypothyroidism following the resolution of the hyperthyroid state.

Drug Regimen:

  • Naproxen 500 to 1000 mg per day in two divided doses
  • Ibuprofen 1200 to 3200 mg per day in three or four divided doses
  • Prednisone 40 mg per day orally.
  • Synthetic levothyroxine (L-T4) 1.6–1.8 μg/kg of body weight per day orally.

References

  1. Engkakul P, Mahachoklertwattana P, Poomthavorn P (2011). "Eponym : de Quervain thyroiditis". Eur. J. Pediatr. 170 (4): 427–31. doi:10.1007/s00431-010-1306-4. PMID 20886353.
  2. Yamamoto M, Saito S, Sakurada T, Fukazawa H, Yoshida K, Kaise K, Kaise N, Nomura T, Itagaki Y, Yonemitsu K (1987). "Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis". Clin. Endocrinol. (Oxf). 27 (3): 339–44. PMID 3427792.
  3. Volpé R (1993). "The management of subacute (DeQuervain's) thyroiditis". Thyroid. 3 (3): 253–5. PMID 8257868.