Cromoglicate

Jump to navigation Jump to search
Cromoglicate
Clinical data
Routes of
administration
topical: oral, nasal spray, inhaled, eye drops
ATC code
Legal status
Legal status
  • inhaler POM, eye OTC(UK)
Pharmacokinetic data
Bioavailability1%
Elimination half-life1.3 hours
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC23H16O11
Molar mass468.367 g/mol

WikiDoc Resources for Cromoglicate

Articles

Most recent articles on Cromoglicate

Most cited articles on Cromoglicate

Review articles on Cromoglicate

Articles on Cromoglicate in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Cromoglicate

Images of Cromoglicate

Photos of Cromoglicate

Podcasts & MP3s on Cromoglicate

Videos on Cromoglicate

Evidence Based Medicine

Cochrane Collaboration on Cromoglicate

Bandolier on Cromoglicate

TRIP on Cromoglicate

Clinical Trials

Ongoing Trials on Cromoglicate at Clinical Trials.gov

Trial results on Cromoglicate

Clinical Trials on Cromoglicate at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Cromoglicate

NICE Guidance on Cromoglicate

NHS PRODIGY Guidance

FDA on Cromoglicate

CDC on Cromoglicate

Books

Books on Cromoglicate

News

Cromoglicate in the news

Be alerted to news on Cromoglicate

News trends on Cromoglicate

Commentary

Blogs on Cromoglicate

Definitions

Definitions of Cromoglicate

Patient Resources / Community

Patient resources on Cromoglicate

Discussion groups on Cromoglicate

Patient Handouts on Cromoglicate

Directions to Hospitals Treating Cromoglicate

Risk calculators and risk factors for Cromoglicate

Healthcare Provider Resources

Symptoms of Cromoglicate

Causes & Risk Factors for Cromoglicate

Diagnostic studies for Cromoglicate

Treatment of Cromoglicate

Continuing Medical Education (CME)

CME Programs on Cromoglicate

International

Cromoglicate en Espanol

Cromoglicate en Francais

Business

Cromoglicate in the Marketplace

Patents on Cromoglicate

Experimental / Informatics

List of terms related to Cromoglicate

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cromoglicate (INN) (also referred to as cromolyn (USAN) or cromoglycate (former BAN)) is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells.

Uses

It is available as a nasal spray (Rynacrom®(UK), Nasalcrom®) to treat allergic rhinitis, as an inhaler (Intal®) for preventive management of asthma, as eye drops (Opticrom® and Optrex Allergy® (UK), Crolom®) for allergic conjunctivitis, or in an oral form (Gastrocrom®) to treat mastocytosis, dermatographic urticaria and ulcerative colitis.

Sodium cromoglicate has also been shown to reduce symptoms of food allergies, including some cases of chronic migraines.

Mechanism of action

The underlying mechanism of action is not fully understood; for while cromoglicate stabilizes mast cells, this mechanism is probably not why it works in asthma. Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect. It is more likely that these work by inhibiting the response of sensory C fibres to the irritant capsacin, inhibiting local axon reflexes involved in asthma, and may inhibit the release of preformed T cell cytokines and mediators involved in asthma. (see review by Garland, 1991)

Allergic reactions

Allegic reactions may include severe rash internally and externally.

It is known to somewhat inhibit chloride channels (37% +/- 7%) [1] and thus may inhibit the:

  • exaggerated neuronal reflexes triggered by stimulation of irritant receptors on sensory nerve endings (e.g. exercise-induced asthma)
  • release of preformed cytokines from several type of inflammatory cells (T cells, eosinophils) in allergen-induced asthma

Note: Another chemical (NPPB (5-nitro-2(3-phenyl) propylamino-benzoic acid)) was shown, in the same study, to be a more effective chloride channel blocker.

Finally it may act by inhibiting calcium influx.

Cromoglicate is classified as a chromone.

References

  1. Heinke, S (1995). "Inhibition of volume-activated chloride currents in endothelial cells by chromones". Br J Pharmacol. 115(8): 1393–8. PMID 8564197. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)

Template:Antidiarrheals, intestinal anti-inflammatory/anti-infective agents

Template:Asthma and copd rx Template:SIB


Template:WikiDoc Sources