Chondroma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Chondromas arise from rests of growth plate cartilage or chondrocytes that are normally involved in the production and maintainence of the cartilaginous matrix, which consists mainly of collagen and proteoglycans.[1][2] On microscopic histopathological analysis, avascular lobules of hyaline cartilagenous matrix interspersed with chondrocytes, separated by normal marrow are characteristic findings of chondromas.[3][4] On gross pathology, small (usually less than 3 cm), translucent, grey blue, nodular lesions are characteristic findings of enchondroma.[5] Juxta-cortical chondromas (also known as periosteal chondromas) are rare benign chondral tumours that arise from the periosteum of tubular bones.[6]
Pathophysiology
- Chondromas arise from rests of growth plate cartilage or chondrocytes that are normally involved in the production and maintainence of the cartilaginous matrix, which consists mainly of collagen and proteoglycans.[7][8]
- On microscopic histopathological analysis, avascular lobules of hyaline cartilagenous matrix interspersed with chondrocytes, separated by normal marrow are characteristic findings of chondromas. The fibrous capsule may be used in differentiating it from the malignant chondrosarcoma.[3][4]
- On gross pathology, small (usually less than 3 cm), translucent, grey blue, nodular lesions are characteristic findings of enchondroma.[9]
- Juxta-cortical chondromas (also known as periosteal chondromas) are rare benign chondral tumours that arise from the periosteum of tubular bones.[10]
Video
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References
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Chondrocytes. Wikipedia. https://en.wikipedia.org/wiki/Chondrocyte. Accessed on December 16, 2015.
- ↑ 3.0 3.1 Shariat Torbaghan S, Ashouri M, Jalayer Naderi N, Baherini N (2011). "Histopathologic Differentiation between Enchondroma and Well-differentiated Chondrosarcoma: Evaluating the Efficacy of Diagnostic Histologic Structures". J Dent Res Dent Clin Dent Prospects. 5 (3): 98–101. doi:10.5681/joddd.2011.022. PMC 3442455. PMID 22991614.
- ↑ 4.0 4.1 Semenova LA, Bulycheva IV (2007). "[Chondromas (enchondroma, periosteal chondroma, enchondromatosis)]". Arkh Patol. 69 (5): 45–8. PMID 18074822.
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Juxta-cortical chondroma. Radiopedia. http://radiopaedia.org/articles/juxta-cortical-chondroma Accessed on December 15, 2015
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Chondrocytes. Wikipedia. https://en.wikipedia.org/wiki/Chondrocyte. Accessed on December 16, 2015.
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Juxta-cortical chondroma. Radiopedia. http://radiopaedia.org/articles/juxta-cortical-chondroma Accessed on December 15, 2015