Cardiology overview pharmacology

Cardiology Overview
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Acute Coronary Syndromes
Antiplatelets and antithrombins
Cardiomyopathy
Congenital heart disease
Electrophysiology
Heart failure
Hypertension
Imaging
Invasive cardiology
Pericardial disease
Peripheral arterial disease
Pharmacology
Pregnancy
Preoperative evaluation
Prevention
Pulmonary hypertension
Stable angina
Valvular heart disease
Venous thromboembolism

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Drug Drug Interactions

• Cyclosporin co-administration is associated with a higher rate of myositis among statin users as a result of inhibition of CYP3A4. The exception is pravastatin in which this is not a problem.
• Nitrate should not be given to patients who are taking Cialis or Viagra. if the patient has ingested Cialis, then you should wait 48 hours to administer nitrates. If the patient is ingested Viagra, you should wait 24 hours to administer nitrates.

Drug Food Interactions

Grapefruit

• Grapefruit juice inhibits the Cyp 3A4 enzyme which reduces the breakdown of drugs. Grapefruit juice also increases the p- glycoprotein in the intestines which increases drug absorption.
• Amiodarone
• Nifedipine
• Simvastatin
• Lovastatin
• Pravastatin
• Sildenafil (Viagra)