Cardiology overview pharmacology: Difference between revisions

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{{Cardiology overview}}
{{Cardiology overview}}
{{CMG}}
{{CMG}}
==Drug Drug Interactions==
*[[Cyclosporin]] co-administration is associated with a higher rate of [[myositis]] among statin users as a result of inhibition of [[CYP3A4]]. The exception is [[pravastatin]] in which this is not a problem.
* [[Nitrates]] should not be given to patients who are taking Cialis or Viagra.  if the patient has ingested [[Cialis]], then you should wait 48 hours to administer [[nitrates]]. If the patient is ingested [[Viagra]], you should wait 24 hours to administer [[nitrates]].  [[Hypotension]] following [[Viagra]] administration can be treated with [[phenylephrine]], IV fluids and the Trendelenburg position.  [[Esmolol]] can exacerbate the [[hypotension]] associated with Viagra.
* [[Dronedarone]] increases the level of [[simvastatin]] fourfold
* [[Amiodarone]] increases levels of [[simvastatin]]
==Drug Food Interactions==
===Grapefruit===
* Grapefruit juice inhibits the Cyp 3A4 enzyme which reduces the breakdown of drugs.  Grapefruit juice also increases the p- glycoprotein in the intestines which increases drug absorption.
* [[Amiodarone]]
* [[Nifedipine]]
* [[Simvastatin]]
* [[Lovastatin]]
* [[Pravastatin]]
* [[Sildenafil]] (Viagra)
==Drug Side Effects and Toxicity==
* [[Protease inhibitors]] are associated with the development of [[myocardial infarction]] in patients with [[AIDS]].
* The chemotherapeutic agent [[Capecitabine]] has been associated with an increased risk of ACS.
* [[Spironolactone]] is associated with an increased incidence of [[hyperkalemia]].
* [[Pioglitazone]] is associated with an increase in weight and [[peripheral edema]]. There actually does not appear to be an increased risk of [[heart failure]] but an increased vascular permeability.  In patients with edema they should be switched to [[metformin]].
* [[Nesiritide]] can lead to hypertension lasting for a couple of hours.
* Genotyping can be used to dose warfarin in such a manner to reduce hospitalization.
* [[Ranolazine]] and diltiazem can prolong the [[QT interval]]


==References==
==References==

Latest revision as of 20:58, 31 October 2011

Cardiology Overview

Home

Acute Coronary Syndromes

Antiplatelets and antithrombins

Cardiomyopathy

Congenital heart disease

Electrophysiology

Heart failure

Hypertension

Imaging

Invasive cardiology

Pericardial disease

Peripheral arterial disease

Pharmacology

Pregnancy

Preoperative evaluation

Prevention

Pulmonary hypertension

Stable angina

Valvular heart disease

Venous thromboembolism

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Drug Drug Interactions

Drug Food Interactions

Grapefruit

Drug Side Effects and Toxicity

References

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