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==Overview==
==Overview==
Cardiogenic shock may occur in the setting of different [[cardiac]] conditions therefore, assessing its source in the [[cardiac]] [[patient]] may be challenging. These [[cardiac]] conditions may involve different structures of the [[heart]] and originate different pathologies, including: [[myocardial]] or [[pericardial]] disease, [[valvular disease]], [[acute coronary syndrome]] or different mechanical injuries to the [[heart]], described below. Nevertheless, considering the predominance of [[coronary artery disease]] today, [[ACS]] is the most common cause of this type of [[shock]]. To reach the right [[diagnosis]], the clinician will have to gather information from the history and clinical examination, however, since most conditions may present with overlapping [[syndromes]], timing and changes in these findings are of uttermost importance.<ref>{{Cite book  | last1 = Hasdai | first1 = David. | title = Cardiogenic shock : diagnosis and treatmen | date = 2002 | publisher = Humana Press | location = Totowa, N.J. | isbn = 1-58829-025-5 | pages =  }}</ref> Auxiliary tools, such as [[echocardiography]] and [[electrocardiography]], are crucial in differentiating and identifying the possible causes of cardiogenic shock.<ref>{{Cite book  | last1 = Hasdai | first1 = David. | title = Cardiogenic shock : diagnosis and treatmen | date = 2002 | publisher = Humana Press | location = Totowa, N.J. | isbn = 1-58829-025-5 | pages =  }}</ref><ref name="ReynoldsHochman2008">{{cite journal|last1=Reynolds|first1=H. R.|last2=Hochman|first2=J. S.|title=Cardiogenic Shock: Current Concepts and Improving Outcomes|journal=Circulation|volume=117|issue=5|year=2008|pages=686–697|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.106.613596}}</ref>
Cardiogenic shock may occur in the setting of different [[cardiac]] conditions, therefore assessing its source in the [[cardiac]] [[patient]] may be challenging. These [[cardiac]] conditions may involve different structures of the [[heart]] and originate different pathologies, including: [[myocardial]] or [[pericardial]] disease, [[valvular disease]], [[acute coronary syndrome]] or other mechanical injuries that may be causative or simply contributive to the shock, described below. Nevertheless, considering the predominance of [[coronary artery disease]] today, [[ACS]] is the most common cause of this type of [[shock]]. To reach the right [[diagnosis]], the clinician will have to gather information from the history and clinical examination, however, since most conditions may present with overlapping [[syndromes]], timing and changes in these findings are of uttermost importance.<ref>{{Cite book  | last1 = Hasdai | first1 = David. | title = Cardiogenic shock : diagnosis and treatmen | date = 2002 | publisher = Humana Press | location = Totowa, N.J. | isbn = 1-58829-025-5 | pages =  }}</ref> Auxiliary tools, such as [[echocardiography]] and [[electrocardiography]], are crucial in differentiating and identifying the possible causes of cardiogenic shock.<ref>{{Cite book  | last1 = Hasdai | first1 = David. | title = Cardiogenic shock : diagnosis and treatmen | date = 2002 | publisher = Humana Press | location = Totowa, N.J. | isbn = 1-58829-025-5 | pages =  }}</ref><ref name="ReynoldsHochman2008">{{cite journal|last1=Reynolds|first1=H. R.|last2=Hochman|first2=J. S.|title=Cardiogenic Shock: Current Concepts and Improving Outcomes|journal=Circulation|volume=117|issue=5|year=2008|pages=686–697|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.106.613596}}</ref>


==Causes==
==Causes==

Revision as of 14:53, 8 May 2014

Cardiogenic Shock Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cardiogenic shock from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

Cardiogenic shock may occur in the setting of different cardiac conditions, therefore assessing its source in the cardiac patient may be challenging. These cardiac conditions may involve different structures of the heart and originate different pathologies, including: myocardial or pericardial disease, valvular disease, acute coronary syndrome or other mechanical injuries that may be causative or simply contributive to the shock, described below. Nevertheless, considering the predominance of coronary artery disease today, ACS is the most common cause of this type of shock. To reach the right diagnosis, the clinician will have to gather information from the history and clinical examination, however, since most conditions may present with overlapping syndromes, timing and changes in these findings are of uttermost importance.[1] Auxiliary tools, such as echocardiography and electrocardiography, are crucial in differentiating and identifying the possible causes of cardiogenic shock.[2][3]

Causes

Life Threatening Causes

Cardiogenic Shock is a life-threatening condition and must be treated as such irrespective of the causes. Life-threatening conditions may result in death or permanent disability within 24 hours if left untreated.

Common Causes

The most common causes of cardiogenic shock remain:[3]

However, other likewise important causes must be identified. These may be classified according to their nature into:

  • Arrhythmic
  • Mechanical
  • Myopathic
  • Pharmacologic

Causes by Organ System

Cardiovascular Acute aortic perforation, Acute aortic syndrome, Acute coronary syndrome, Acute myocardial infarction, Acute pulmonary embolism, Acute stent thrombosis, Acute valvular regurgitation, Anterior myocardial dysfuntion, Aortic dissection, Aortic insufficiency, Aortic regurgitation, Aortic stenosis, Apical ballooning cardiomyopathy, Arrhythmias, Atrial fibrillation, Atrial flutter, Atrial myxoma, Atrioventricular block, Bezold-Jarisch reflex, Cardiac tamponade, Chordal rupture, Coarctation of the aorta, Compression of the heart, Congenital lesions, Congestive heart failure, Constrictive pericarditis, Coronary artery bypass grafting, Coronary artery disease, Dilated cardiomyopathy, Endocarditis, Excess ventricular wall stress, Free wall rupture, Hemorrhagic pericardial effusion, Hypertensive crisis, Hypertrophic cardiomyopathy, Hypophosphatemia, Hypoxic pulmonary vasoconstriction, Inferior myocardial infarction, Inferoposterior infarction, Interventricular septum rupture, Left ventricle failure, Left ventricular free wall rupture, Mechanical obstruction, Mitral regurgitation, Mitral stenosis, Multivessel coronary artery disease, Myocardial disease, Myocardial infarction, Myocarditis, Myopericarditis, Non-ST elevation myocardial infarction (NSTEMI), Papillary muscle dysfunction, Papillary muscle rupture, Pericardial disease, Pericardial effusion, Pericardial tamponade, Pneumothorax, Prior valvular disease, Pulmonary embolism, Retrograde dissection of ascending aorta, Right ventricle infarction, Right ventricular failure, Rupture of chordae tendineae, Ruptured ventricular free wall aneurysm, Septic shock with myocardial depression, Severe cardiomyopathy, Severe pulmonary hypertension, Sinus bradycardia, ST elevation myocardial infarction (STEMI), Stress-induced cardiomyopathy, Subendocardial ischemia, Takotsubo cardiomyopathy, Tension pneumothorax, Three vessel coronary disease, Unsuspected coronary dissection, Unsuspected coronary perforation, Valvular defect, Valvular disease, Vasodilators, Venodilators, Ventricular fibrillation, Ventricular septal defect, Ventricular septal rupture, Ventricular tachycardia
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Anaphylaxis, Angiotensin converting enzyme inhibitors, Beta-blockers, Calcium channel blockers, Diuretics, Morphine, Nitrates, Vasodilators, Venodilators
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Congenital lesions, Valvular defect, Ventricular septal defect
Hematologic Hypophosphatemia
Iatrogenic Acute aortic perforation, Acute stent thrombosis, Anaphylaxis, Angiotensin converting enzyme inhibitors, Beta-blockers, Calcium channel blockers, Coronary artery bypass grafting, Diuretics, Iatrogenic, Morphine, Nitrates, Unsuspected coronary dissection, Unsuspected coronary perforation, Vasodilators, Venodilators
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic Apical ballooning cardiomyopathy, Bezold-Jarisch reflex, Sinus bradycardia, Stress-induced cardiomyopathy, Takotsubo cardiomyopathy
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Atrial myxoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Acute pulmonary embolism, Hypoxic pulmonary vasoconstriction, Pneumothorax, Pulmonary embolism, Severe pulmonary hypertension, Tension pneumothorax
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Anaphylaxis, Constrictive pericarditis, Endocarditis, Myocarditis, Myopericarditis, Septic shock with myocardial depression
Sexual No underlying causes
Trauma Acute aortic perforation, Aortic dissection, Chordal rupture, Compression of the heart, Papillary muscle rupture, Pericardial tamponade, Retrograde dissection of ascending aorta, Rupture of chordae tendineae, Trauma, Ventricular septal rupture
Urologic No underlying causes
Miscellaneous Acute aortic syndrome, Acute coronary syndrome, Acute myocardial infarction, Acute pulmonary embolism, Acute valvular regurgitation, Anterior myocardial dysfuntion, Aortic dissection, Aortic insufficiency, Aortic regurgitation, Aortic stenosis, Apical ballooning cardiomyopathy, Arrhythmias, Atrial fibrillation, Cardiac tamponade, Chordal rupture, Coarctation of the aorta, Compression of the heart, Congestive heart failure, Coronary artery disease, Dilated cardiomyopathy, Endocarditis, Excess ventricular wall stress, Free wall rupture, Hemorrhagic pericardial effusion, Hypertensive crisis, Hypertrophic cardiomyopathy, Hypophosphatemia, Hypoxic pulmonary vasoconstriction, Inferior myocardial infarction, Inferoposterior infarction, Interventricular septum rupture, Left ventricle failure, Left ventricular free wall rupture, Mechanical obstruction, Mitral regurgitation, Mitral stenosis, Multivessel coronary artery disease, Myocardial disease, Myocardial infarction, Myocarditis, Myopericarditis, Non-ST elevation myocardial infarction (NSTEMI), Papillary muscle dysfunction, Papillary muscle rupture, Pericardial disease, Pericardial effusion, Pericardial tamponade, Pneumothorax, Prior valvular disease, Pulmonary embolism, Retrograde dissection of ascending aorta, Right ventricle infarction, Right ventricular failure, Rupture of chordae tendineae, Ruptured ventricular free wall aneurysm, Septic shock with myocardial depression, Severe cardiomyopathy, Severe pulmonary hypertension, Sinus bradycardia, ST elevation myocardial infarction (STEMI), Stress-induced cardiomyopathy, Subendocardial ischemia, Takotsubo cardiomyopathy, Tension pneumothorax, Three vessel coronary disease, Valvular defect, Valvular disease, Ventricular fibrillation, Ventricular septal defect, Ventricular septal rupture, Ventricular tachycardia

Causes in Alphabetical Order

Causes of Cardiogenic Shock Classified According to Underlying Pathophysiologic Mechanism

Systolic Left Ventricular Dysfunction

Diastolic Left Ventricular Dysfunction

  • Excess wall stress

Obstruction of Left Ventricular Outflow and Increased After Load

Reversal of Flow into the Left Ventricle

Inadequate Left Ventricular Filling due to Mechanical Causes

Inadequate Left Ventricular Filling due to Inadequate Filling Time

Conduction Abnormalities

Mechanical Defect

Right Ventricular Failure

Iatrogenic

Miscellaneous

References

  1. Hasdai, David. (2002). Cardiogenic shock : diagnosis and treatmen. Totowa, N.J.: Humana Press. ISBN 1-58829-025-5.
  2. Hasdai, David. (2002). Cardiogenic shock : diagnosis and treatmen. Totowa, N.J.: Humana Press. ISBN 1-58829-025-5.
  3. 3.0 3.1 Reynolds, H. R.; Hochman, J. S. (2008). "Cardiogenic Shock: Current Concepts and Improving Outcomes". Circulation. 117 (5): 686–697. doi:10.1161/CIRCULATIONAHA.106.613596. ISSN 0009-7322.
  4. Hasdai, David. (2002). Cardiogenic shock : diagnosis and treatmen. Totowa, N.J.: Humana Press. ISBN 1-58829-025-5.
  5. Gianni, M. (2006). "Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review". European Heart Journal. 27 (13): 1523–1529. doi:10.1093/eurheartj/ehl032. ISSN 0195-668X.


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