CYP1A2: Difference between revisions

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*[[amiodarone]] ([[antiarrhythmic agent]])  
*[[amiodarone]] ([[antiarrhythmic agent]])  
*[[cimetidine]] ([[H2-receptor antagonist]])  
*[[cimetidine]] ([[H2-receptor antagonist]])  
*[[furafylline]]
*furafylline
*[[interferon]] ([[antiviral]], [[antiseptic]], [[antioncogenic]])  
*[[interferon]] ([[antiviral]], [[antiseptic]], [[antioncogenic]])  
*[[methoxsalen]] (in [[psoriasis]])  
*[[methoxsalen]] (in [[psoriasis]])  
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**[[grapefruit juice]] (its bitter flavanone [[naringenin]])<ref>{{cite journal |author=Edwards DJ, Bernier SM |title=Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man |journal=Life Sciences |volume=59 |issue=13 |pages=1025-1030 |year=1996 |pmid=8485024}}</ref>
**[[grapefruit juice]] (its bitter flavanone [[naringenin]])<ref>{{cite journal |author=Edwards DJ, Bernier SM |title=Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man |journal=Life Sciences |volume=59 |issue=13 |pages=1025-1030 |year=1996 |pmid=8485024}}</ref>
**[[broccoli]]  
**[[broccoli]]  
**[[brussel sprout]]s
**brussel sprouts
**[[chargrill]]ed [[meat]]  
**chargrilled [[meat]]  
*[[insulin]] (in [[diabetes]])  
*[[insulin]] (in [[diabetes]])  
*[[modafinil]] ([[eugeroic]])  
*[[modafinil]] ([[eugeroic]])  

Revision as of 20:40, 7 January 2009


Cytochrome P450, family 1, subfamily A, polypeptide 2
PDB rendering based on 2hi4.
Identifiers
Symbols CYP1A2 ; CP12; P3-450; P450(PA)
External IDs Template:OMIM5 Template:MGI HomoloGene68082
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

Expression of CYP1A2 appears to be induced by various dietary constituents.[1]


CYP1A2 Ligands

Table of selected substrates, inducers and inhibitors of CYP1A21

Substrates Inhibitors Inducers
Often mentioned [2]:

Other:

Strong [3]:

unspecified:

Often mentioned[2]:

Other:

References

  1. Fontana R, Lown K, Paine M, Fortlage L, Santella R, Felton J, Knize M, Greenberg A, Watkins P (1999). "Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers". Gastroenterology. 117 (1): 89–98. PMID 10381914.
  2. 2.0 2.1 Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  3. Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
  4. Edwards DJ, Bernier SM (1996). "Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man". Life Sciences. 59 (13): 1025–1030. PMID 8485024.
  • Meijerman I, Beijnen J, Schellens J. "Herb-drug interactions in oncology: focus on mechanisms of induction". Oncologist. 11 (7): 742–52. PMID 16880233.

Further reading

  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. PMID 9890157.
  • Landi MT, Sinha R, Lang NP, Kadlubar FF (1999). "Human cytochrome P4501A2". IARC Sci. Publ. (148): 173–95. PMID 10493258.
  • Nelson DR, Zeldin DC, Hoffman SM; et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. PMID 15128046.
  • Ikeya K, Jaiswal AK, Owens RA; et al. (1990). "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression". Mol. Endocrinol. 3 (9): 1399–408. PMID 2575218.
  • Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989). "Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7696–700. PMID 2813353.
  • Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH (1986). "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6". DNA. 4 (5): 395–400. PMID 3000715.
  • Quattrochi LC, Pendurthi UR, Okino ST; et al. (1986). "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6731–5. PMID 3462722.
  • Wrighton SA, Campanile C, Thomas PE; et al. (1986). "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat". Mol. Pharmacol. 29 (4): 405–10. PMID 3517618.
  • Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1988). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15". J. Exp. Pathol. 3 (1): 1–17. PMID 3681487.
  • Jaiswal AK, Nebert DW, Gonzalez FJ (1986). "Human P3(450): cDNA and complete amino acid sequence". Nucleic Acids Res. 14 (16): 6773–4. PMID 3755823.
  • Eugster HP, Probst M, Würgler FE, Sengstag C (1993). "Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae". Drug Metab. Dispos. 21 (1): 43–9. PMID 8095225.
  • Schweikl H, Taylor JA, Kitareewan S; et al. (1994). "Expression of CYP1A1 and CYP1A2 genes in human liver". Pharmacogenetics. 3 (5): 239–49. PMID 8287062.
  • Yamazaki H, Inoue K, Mimura M; et al. (1996). "7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes". Biochem. Pharmacol. 51 (3): 313–9. PMID 8573198.
  • Hakkola J, Raunio H, Purkunen R; et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy". Biochem. Pharmacol. 52 (2): 379–83. PMID 8694864.
  • Guengerich FP, Johnson WW (1998). "Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems". Biochemistry. 36 (48): 14741–50. doi:10.1021/bi9719399. PMID 9398194.
  • Wacke R, Kirchner A, Prall F; et al. (1998). "Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis". Pancreas. 16 (4): 521–8. PMID 9598815.
  • Macé K, Bowman ED, Vautravers P; et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues". Eur. J. Cancer. 34 (6): 914–20. PMID 9797707.
  • Huang JD, Guo WC, Lai MD; et al. (1999). "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese". Drug Metab. Dispos. 27 (1): 98–101. PMID 9884316.
  • Tatemichi M, Nomura S, Ogura T; et al. (1999). "Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia". Cancer Res. 59 (16): 3893–8. PMID 10463577.

See also


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