CRTC2: Difference between revisions

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Latest revision as of 02:33, 27 October 2017

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.^[1]^[2]^[3]

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.^[4]

Interactions

CRTC2 has been shown to interact with SNF1LK2^[5] and YWHAQ.^[5]^[6]

References

↑ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
↑ Cheng A, Saltiel AR (Mar 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. doi:10.1002/bies.20375. PMID 16479585.
↑ ^5.0 ^5.1 Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR (Dec 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.
Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (Jul 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
Yang Q, Inoki K, Ikenoue T, Guan KL (Oct 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes & Development. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (Jun 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". The EMBO Journal. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMC 1894761. PMID 17476304.
Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (Jun 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation". Proceedings of the National Academy of Sciences of the United States of America. 104 (24): 10175–80. doi:10.1073/pnas.0704170104. PMC 1891214. PMID 17548807.

External links

CRTC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CRTC2 genome location and CRTC2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".

[pmid14506290-2] Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.

[pmid14536081-3] Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.

[pmid16479585-4] Cheng A, Saltiel AR (Mar 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. doi:10.1002/bies.20375. PMID 16479585.

[pmid15454081-5] 5.0 ^5.1 Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.

[pmid17353931-6] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''CREB regulated transcription coactivator 2''', also known as '''CRTC2''', is a [[protein]] which in humans is encoded by the '''CRTC2''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRTC2 CREB regulated transcription coactivator 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200186| accessdate = }}</ref><ref name="pmid14506290">{{cite journal | vauthors = Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA | title = Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 21 | pages = 12147–52 | date = Oct 2003 | pmid = 14506290 | pmc = 218727 | doi = 10.1073/pnas.1932773100 }}</ref><ref name="pmid14536081">{{cite journal | vauthors = Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M | title = TORCs: transducers of regulated CREB activity | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 413–23 | date = Aug 2003 | pmid = 14536081 | doi = 10.1016/j.molcel.2003.08.013 }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = CREB regulated transcription coactivator 2
- | HGNCid = 27301
- | Symbol = CRTC2
- | AltSymbols =; RP11-422P24.6; TORC2
- | OMIM = 608972
- | ECnumber =
- | Homologene = 18765
- | MGIid = 1921593
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 200186
-    | Hs_Ensembl = ENSG00000160741
-    | Hs_RefseqProtein = NP_859066
-    | Hs_RefseqmRNA = NM_181715
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 152186775
-    | Hs_GenLoc_end = 152197725
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 74343
-    | Mm_Ensembl = ENSMUSG00000027936
-    | Mm_RefseqmRNA = NM_028881
-    | Mm_RefseqProtein = NP_083157
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 3
-    | Mm_GenLoc_start = 90340213
-    | Mm_GenLoc_end = 90350052
-    | Mm_Uniprot =
-  }}
-}}
-'''CREB regulated transcription coactivator 2''', also known as '''CRTC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRTC2 CREB regulated transcription coactivator 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200186| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+CRTC2, initially called TORC2, is a transcriptional [[coactivator (genetics)|coactivator]] for the transcription factor [[CREB]] and a central regulator of
-{{PBB_Summary
+[[gluconeogenesis|gluconeogenic]] [[gene expression]] in response to [[cyclic adenosine monophosphate|cAMP]].<ref name="pmid16479585">{{cite journal | vauthors = Cheng A, Saltiel AR | title = More TORC for the gluconeogenic engine | journal = BioEssays | volume = 28 | issue = 3 | pages = 231–4 | date = Mar 2006 | pmid = 16479585 | doi = 10.1002/bies.20375 }}</ref>
-| section_title =
-| summary_text =
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+CRTC2 has been shown to [[Protein-protein interaction|interact]] with [[SNF1LK2]]<ref name=pmid15454081>{{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}</ref> and [[YWHAQ]].<ref name=pmid15454081/><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref>
-{{refbegin | 2}}
-{{PBB_Further_reading
+== References ==
-| citations =
+{{reflist}}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+== Further reading ==
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+{{refbegin|33em}}
-*{{cite journal  | author=Iourgenko V, Zhang W, Mickanin C, ''et al.'' |title=Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12147-52 |year= 2003 |pmid= 14506290 |doi= 10.1073/pnas.1932773100 }}
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-*{{cite journal  | author=Conkright MD, Canettieri G, Screaton R, ''et al.'' |title=TORCs: transducers of regulated CREB activity. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 413-23 |year= 2003 |pmid= 14536081 |doi=  }}
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA | title = Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 21 | pages = 12147–52 | date = Oct 2003 | pmid = 14506290 | pmc = 218727 | doi = 10.1073/pnas.1932773100 }}
-*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
+* {{cite journal | vauthors = Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M | title = TORCs: transducers of regulated CREB activity | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 413–23 | date = Aug 2003 | pmid = 14536081 | doi = 10.1016/j.molcel.2003.08.013 }}
-*{{cite journal  | author=Screaton RA, Conkright MD, Katoh Y, ''et al.'' |title=The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. |journal=Cell |volume=119 |issue= 1 |pages= 61-74 |year= 2004 |pmid= 15454081 |doi= 10.1016/j.cell.2004.09.015 }}
+* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
-*{{cite journal  | author=Al-Hakim AK, Göransson O, Deak M, ''et al.'' |title=14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. |journal=J. Cell. Sci. |volume=118 |issue= Pt 23 |pages= 5661-73 |year= 2006 |pmid= 16306228 |doi= 10.1242/jcs.02670 }}
+* {{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}
-*{{cite journal  | author=Siu YT, Chin KT, Siu KL, ''et al.'' |title=TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. |journal=J. Virol. |volume=80 |issue= 14 |pages= 7052-9 |year= 2006 |pmid= 16809310 |doi= 10.1128/JVI.00103-06 }}
+* {{cite journal | vauthors = Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR | title = 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK | journal = Journal of Cell Science | volume = 118 | issue = Pt 23 | pages = 5661–73 | date = Dec 2005 | pmid = 16306228 | doi = 10.1242/jcs.02670 }}
-*{{cite journal  | author=Wu Z, Huang X, Feng Y, ''et al.'' |title=Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 39 |pages= 14379-84 |year= 2006 |pmid= 16980408 |doi= 10.1073/pnas.0606714103 }}
+* {{cite journal | vauthors = Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY | title = TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats | journal = Journal of Virology | volume = 80 | issue = 14 | pages = 7052–9 | date = Jul 2006 | pmid = 16809310 | pmc = 1489057 | doi = 10.1128/JVI.00103-06 }}
-*{{cite journal  | author=Yang Q, Inoki K, Ikenoue T, Guan KL |title=Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. |journal=Genes Dev. |volume=20 |issue= 20 |pages= 2820-32 |year= 2006 |pmid= 17043309 |doi= 10.1101/gad.1461206 }}
+* {{cite journal | vauthors = Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC | title = Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 39 | pages = 14379–84 | date = Sep 2006 | pmid = 16980408 | pmc = 1569674 | doi = 10.1073/pnas.0606714103 }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
+* {{cite journal | vauthors = Yang Q, Inoki K, Ikenoue T, Guan KL | title = Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity | journal = Genes & Development | volume = 20 | issue = 20 | pages = 2820–32 | date = Oct 2006 | pmid = 17043309 | pmc = 1619946 | doi = 10.1101/gad.1461206 }}
-*{{cite journal  | author=Ravnskjaer K, Kester H, Liu Y, ''et al.'' |title=Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. |journal=EMBO J. |volume=26 |issue= 12 |pages= 2880-9 |year= 2007 |pmid= 17476304 |doi= 10.1038/sj.emboj.7601715 }}
+* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
-*{{cite journal  | author=Kuraishy AI, French SW, Sherman M, ''et al.'' |title=TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 24 |pages= 10175-80 |year= 2007 |pmid= 17548807 |doi= 10.1073/pnas.0704170104 }}
+* {{cite journal | vauthors = Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M | title = Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression | journal = The EMBO Journal | volume = 26 | issue = 12 | pages = 2880–9 | date = Jun 2007 | pmid = 17476304 | pmc = 1894761 | doi = 10.1038/sj.emboj.7601715 }}
-}}
+* {{cite journal | vauthors = Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA | title = TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 24 | pages = 10175–80 | date = Jun 2007 | pmid = 17548807 | pmc = 1891214 | doi = 10.1073/pnas.0704170104 }}
 {{refend}}
-{{protein-stub}}
+== External links ==
-{{WikiDoc Sources}}
+* {{MeshName|CRTC2+protein,+human}}
+* {{UCSC gene info|CRTC2}}
+{{Transcription coregulators}}
+[[Category:Gene expression]]
+[[Category:Transcription coregulators]]
+{{gene-1-stub}}

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

CRTC2: Difference between revisions

Latest revision as of 02:33, 27 October 2017

Contents

Function

Interactions

References

Further reading

External links

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