CDH6: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{for|the airport in Ontario, Canada|Delhi Aerodrome}}
{{PBB_Controls
{{Use dmy dates|date=June 2016}}
| update_page = yes
{{Underlinked|date=May 2016}}
| require_manual_inspection = no
{{Infobox_gene}}
| update_protein_box = yes
'''Cadherin-6''' is a [[protein]] that in humans is encoded by the ''CDH6'' [[gene]].<ref name="pmid7743525">{{cite journal | vauthors = Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S | title = Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells | journal = Cancer Res | volume = 55 | issue = 10 | pages = 2206–11 |date=June 1995 | pmid = 7743525 | pmc =  | doi =  }}</ref><ref name="pmid10191097">{{cite journal | vauthors = Chalmers IJ, Hofler H, Atkinson MJ | title = Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma | journal = Genomics | volume = 57 | issue = 1 | pages = 160–3 |date=June 1999 | pmid = 10191097 | pmc =  | doi = 10.1006/geno.1998.5717 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1004| accessdate = }}</ref>
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Cadherin 6, type 2, K-cadherin (fetal kidney)
| HGNCid = 1765
| Symbol = CDH6
| AltSymbols =; KCAD
| OMIM = 603007
| ECnumber =
| Homologene = 21027
| MGIid = 107435
| GeneAtlas_image1 = PBB_GE_CDH6_205532_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDH6_205533_s_at_tn.png
  | GeneAtlas_image3 = PBB_GE_CDH6_210602_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1004
    | Hs_Ensembl = ENSG00000113361
    | Hs_RefseqProtein = NP_004923
    | Hs_RefseqmRNA = NM_004932
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 31229553
    | Hs_GenLoc_end = 31365010
    | Hs_Uniprot = P55285
    | Mm_EntrezGene = 12563
    | Mm_Ensembl = ENSMUSG00000039385
    | Mm_RefseqmRNA = NM_007666
    | Mm_RefseqProtein = NP_031692
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 12978925
    | Mm_GenLoc_end = 13036602
    | Mm_Uniprot = Q3KNY8
  }}
}}
'''Cadherin 6, type 2, K-cadherin (fetal kidney)''', also known as '''CDH6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1004| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.<ref name="entrez">{{cite web | title = Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1004| accessdate = }}</ref>
| summary_text = This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=MacCalman CD, Getsios S, Chen GT |title=Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation. |journal=Am. J. Reprod. Immunol. |volume=39 |issue= 2 |pages= 96-107 |year= 1998 |pmid= 9506208 |doi=  }}
*{{cite journal  | vauthors=MacCalman CD, Getsios S, Chen GT |title=Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation. |journal=Am. J. Reprod. Immunol. |volume=39 |issue= 2 |pages= 96–107 |year= 1998 |pmid= 9506208 |doi=  10.1111/j.1600-0897.1998.tb00341.x}}
*{{cite journal  | author=Suzuki S, Sano K, Tanihara H |title=Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. |journal=Cell Regul. |volume=2 |issue= 4 |pages= 261-70 |year= 1991 |pmid= 2059658 |doi=  }}
*{{cite journal  | vauthors=Suzuki S, Sano K, Tanihara H |title=Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. |journal=Cell Regul. |volume=2 |issue= 4 |pages= 261–70 |year= 1991 |pmid= 2059658 |doi=  10.1091/mbc.2.4.261| pmc=361775 }}
*{{cite journal  | author=Shimoyama Y, Gotoh M, Terasaki T, ''et al.'' |title=Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells. |journal=Cancer Res. |volume=55 |issue= 10 |pages= 2206-11 |year= 1995 |pmid= 7743525 |doi=  }}
*{{cite journal  | vauthors=Paul R, Ewing CM, Robinson JC |title=Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. |journal=Cancer Res. |volume=57 |issue= 13 |pages= 2741–8 |year= 1997 |pmid= 9205085 |doi=  |display-authors=etal}}
*{{cite journal  | author=Paul R, Ewing CM, Robinson JC, ''et al.'' |title=Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. |journal=Cancer Res. |volume=57 |issue= 13 |pages= 2741-8 |year= 1997 |pmid= 9205085 |doi=  }}
*{{cite journal  | vauthors=Getsios S, Chen GT, Stephenson MD |title=Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. |journal=Dev. Dyn. |volume=211 |issue= 3 |pages= 238–47 |year= 1998 |pmid= 9520111 |doi= 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I |display-authors=etal}}
*{{cite journal  | author=Getsios S, Chen GT, Stephenson MD, ''et al.'' |title=Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. |journal=Dev. Dyn. |volume=211 |issue= 3 |pages= 238-47 |year= 1998 |pmid= 9520111 |doi= 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I }}
*{{cite journal  | vauthors=Kremmidiotis G, Baker E, Crawford J |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467–71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281 |display-authors=etal}}
*{{cite journal  | author=Kremmidiotis G, Baker E, Crawford J, ''et al.'' |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467-71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281 }}
*{{cite journal  | vauthors=Shimoyama Y, Takeda H, Yoshihara S |title=Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11987–94 |year= 1999 |pmid= 10207020 |doi=10.1074/jbc.274.17.11987 |display-authors=etal}}
*{{cite journal  | author=Chalmers IJ, Höfler H, Atkinson MJ |title=Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. |journal=Genomics |volume=57 |issue= 1 |pages= 160-3 |year= 1999 |pmid= 10191097 |doi= 10.1006/geno.1998.5717 }}
*{{cite journal  | vauthors=Shimoyama Y, Tsujimoto G, Kitajima M, Natori M |title=Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 159–67 |year= 2001 |pmid= 10861224 |doi=10.1042/0264-6021:3490159  | pmc=1221133 }}
*{{cite journal  | author=Shimoyama Y, Takeda H, Yoshihara S, ''et al.'' |title=Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11987-94 |year= 1999 |pmid= 10207020 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Shimoyama Y, Tsujimoto G, Kitajima M, Natori M |title=Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 159-67 |year= 2001 |pmid= 10861224 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|CDH6}}
* {{UCSC gene details|CDH6}}
 
{{Cell adhesion molecules}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-5-stub}}

Latest revision as of 09:28, 30 August 2017

For the airport in Ontario, Canada, see Delhi Aerodrome.

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.[1][2][3]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.[3]

References

  1. ↑ Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID 7743525.
  2. ↑ Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  3. ↑ 3.0 3.1 "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CDH6&oldid=1420492"