CDH16: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (1 revision imported)
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cadherin-16''' is a protein that in humans is encoded by the ''CDH16'' gene.<ref name="pmid9721215">{{cite journal | vauthors = Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS | title = cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin | journal = Genomics | volume = 51 | issue = 3 | pages = 445–51 |date=Oct 1998 | pmid = 9721215 | pmc =  | doi = 10.1006/geno.1998.5402 }}</ref><ref name="pmid7615566">{{cite journal | vauthors = Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS | title = Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family | journal = J Biol Chem | volume = 270 | issue = 29 | pages = 17594–601 |date=Aug 1995 | pmid = 7615566 | pmc =  | doi =10.1074/jbc.270.29.17594 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDH16 cadherin 16, KSP-cadherin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1014| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cadherin 16, KSP-cadherin
| HGNCid = 1755
| Symbol = CDH16
| AltSymbols =;
| OMIM = 603118
| ECnumber =
| Homologene = 2997
| MGIid = 106671
  | GeneAtlas_image1 = PBB_GE_CDH16_206517_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1014
    | Hs_Ensembl = ENSG00000166589
    | Hs_RefseqProtein = NP_004053
    | Hs_RefseqmRNA = NM_004062
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 65499526
    | Hs_GenLoc_end = 65510267
    | Hs_Uniprot = O75309
    | Mm_EntrezGene = 12556
    | Mm_Ensembl = ENSMUSG00000031881
    | Mm_RefseqmRNA = NM_007663
    | Mm_RefseqProtein = NP_031689
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 107503270
    | Mm_GenLoc_end = 107513392
    | Mm_Uniprot = Q3TPA4
  }}
}}
'''Cadherin 16, KSP-cadherin''', also known as '''CDH16''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDH16 cadherin 16, KSP-cadherin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1014| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.<ref name="entrez">{{cite web | title = Entrez Gene: CDH16 cadherin 16, KSP-cadherin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1014| accessdate = }}</ref>
| summary_text = This gene is a member of the [[cadherin]] superfamily, genes encoding calcium-dependent, membrane-associated [[glycoprotein]]s. Mapped to a previously identified cluster of cadherin genes on [[chromosome 16]]q22.1, the gene localizes with superfamily members [[CDH1 (gene)|CDH1]], [[CDH3 (gene)|CDH3]], [[CDH5]], [[CDH8]] and [[CDH11]]. The protein consists of an [[extracellular domain]] containing 6 cadherin domains, a [[transmembrane region]] and a truncated [[cytoplasmic]] domain but lacks the [[prosequence]] and [[tripeptide]] HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the [[morphogenic]] direction of tissue development.<ref name="entrez">{{cite web | title = Entrez Gene: CDH16 cadherin 16, KSP-cadherin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1014| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Thomson RB, Igarashi P, Biemesderfer D, ''et al.'' |title=Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family. |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17594-601 |year= 1995 |pmid= 7615566 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Thomson RB, Aronson PS |title=Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney. |journal=Am. J. Physiol. |volume=277 |issue= 1 Pt 2 |pages= F146–56 |year= 1999 |pmid= 10409308 |doi=  }}
*{{cite journal  | author=Thomson RB, Ward DC, Quaggin SE, ''et al.'' |title=cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin. |journal=Genomics |volume=51 |issue= 3 |pages= 445-51 |year= 1998 |pmid= 9721215 |doi= 10.1006/geno.1998.5402 }}
*{{cite journal  | vauthors=Baudry D, Jeanpierre C |title=Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 253–4 |year= 2000 |pmid= 10828602 |doi=10.1159/000015531 }}
*{{cite journal  | author=Thomson RB, Aronson PS |title=Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney. |journal=Am. J. Physiol. |volume=277 |issue= 1 Pt 2 |pages= F146-56 |year= 1999 |pmid= 10409308 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Baudry D, Jeanpierre C |title=Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 253-4 |year= 2000 |pmid= 10828602 |doi=  }}
*{{cite journal  | vauthors=Thomson RB, Mentone S, Kim R |title=Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 5 |pages= F870–80 |year= 2003 |pmid= 12851251 |doi= 10.1152/ajprenal.00153.2003 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Thomson RB, Mentone S, Kim R, ''et al.'' |title=Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 5 |pages= F870-80 |year= 2003 |pmid= 12851251 |doi= 10.1152/ajprenal.00153.2003 }}
*{{cite journal  | vauthors=Wendeler MW, Praus M, Jung R |title=Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 345–55 |year= 2004 |pmid= 15023525 |doi= 10.1016/j.yexcr.2003.11.022 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Wendeler MW, Praus M, Jung R, ''et al.'' |title=Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 345-55 |year= 2004 |pmid= 15023525 |doi= 10.1016/j.yexcr.2003.11.022 }}
*{{cite journal  | vauthors=Hishikawa K, Marumo T, Miura S |title=Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 288–91 |year= 2005 |pmid= 15670782 |doi= 10.1016/j.bbrc.2004.12.167 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Thedieck C, Kuczyk M, Klingel K |title=Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. |journal=Br. J. Cancer |volume=92 |issue= 11 |pages= 2010–7 |year= 2005 |pmid= 15886705 |doi= 10.1038/sj.bjc.6602597 | pmc=2361784 |display-authors=etal}}
*{{cite journal  | author=Hishikawa K, Marumo T, Miura S, ''et al.'' |title=Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 288-91 |year= 2005 |pmid= 15670782 |doi= 10.1016/j.bbrc.2004.12.167 }}
*{{cite journal  | vauthors=Kuehn A, Paner GP, Skinnider BF |title=Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. |journal=Am. J. Surg. Pathol. |volume=31 |issue= 10 |pages= 1528–33 |year= 2007 |pmid= 17895753 |doi= 10.1097/PAS.0b013e318058818c |display-authors=etal}}
*{{cite journal  | author=Thedieck C, Kuczyk M, Klingel K, ''et al.'' |title=Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. |journal=Br. J. Cancer |volume=92 |issue= 11 |pages= 2010-7 |year= 2005 |pmid= 15886705 |doi= 10.1038/sj.bjc.6602597 }}
*{{cite journal  | author=Kuehn A, Paner GP, Skinnider BF, ''et al.'' |title=Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. |journal=Am. J. Surg. Pathol. |volume=31 |issue= 10 |pages= 1528-33 |year= 2007 |pmid= 17895753 |doi= 10.1097/PAS.0b013e318058818c }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|CDH16}}
* {{UCSC gene details|CDH16}}
 
{{Cell adhesion molecules}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-16-stub}}

Latest revision as of 09:20, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[3]

References

  1. ↑ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215.
  2. ↑ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566.
  3. ↑ 3.0 3.1 "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CDH16&oldid=1524647"