Bartter syndrome natural history, complications and prognosis: Difference between revisions

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Kidney failure is a possible complication.
Kidney failure is a possible complication.
*Bartter syndrome type I and type II are salt-wasting renal tubular disorders that are clinically characterized by polyhydramnios leading to premature delivery, marked polyuria, and a tendency towards nephrocalcinosis.<ref name="pmid18695706">{{cite journal| author=Seyberth HW| title=An improved terminology and classification of Bartter-like syndromes. | journal=Nat Clin Pract Nephrol | year= 2008 | volume= 4 | issue= 10 | pages= 560-7 | pmid=18695706 | doi=10.1038/ncpneph0912 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18695706  }} </ref>
*Bartter syndrome type I and type II are salt-wasting renal tubular disorders that are clinically characterized by polyhydramnios leading to premature delivery, marked polyuria, and a tendency towards nephrocalcinosis.<ref name="pmid18695706">{{cite journal| author=Seyberth HW| title=An improved terminology and classification of Bartter-like syndromes. | journal=Nat Clin Pract Nephrol | year= 2008 | volume= 4 | issue= 10 | pages= 560-7 | pmid=18695706 | doi=10.1038/ncpneph0912 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18695706  }} </ref>
*Gallstones might represent a new complication of antenatal Bartter syndrome.<ref name="pmid20219833">{{cite journal| author=Puricelli E, Bettinelli A, Borsa N, Sironi F, Mattiello C, Tammaro F | display-authors=etal| title=Long-term follow-up of patients with Bartter syndrome type I and II. | journal=Nephrol Dial Transplant | year= 2010 | volume= 25 | issue= 9 | pages= 2976-81 | pmid=20219833 | doi=10.1093/ndt/gfq119 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20219833  }} </ref>
*Gallstones might represent a new complication of antenatal Bartter syndrome.<ref name="pmid20219833">{{cite journal| author=Puricelli E, Bettinelli A, Borsa N, Sironi F, Mattiello C, Tammaro F | display-authors=etal| title=Long-term follow-up of patients with Bartter syndrome type I and II. | journal=Nephrol Dial Transplant | year= 2010 | volume= 25 | issue= 9 | pages= 2976-81 | pmid=20219833 | doi=10.1093/ndt/gfq119 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20219833  }} </ref> Gallstone formation might result from an altered function of either the sodium–potassium–chloride cotransporter or the channel ROMK within the hepatobiliary system.<ref name="pmid20219833">{{cite journal| author=Puricelli E, Bettinelli A, Borsa N, Sironi F, Mattiello C, Tammaro F | display-authors=etal| title=Long-term follow-up of patients with Bartter syndrome type I and II. | journal=Nephrol Dial Transplant | year= 2010 | volume= 25 | issue= 9 | pages= 2976-81 | pmid=20219833 | doi=10.1093/ndt/gfq119 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20219833  }} </ref>
*[[Hypokalemia]] in [[Bartter syndrome]] can be exacerbated by [[electrolytes]] and fluid losses. [[Diarrhea]], [[vomiting]], [[alcohol abuse]], [[cocaine]], or other drugs result in [[electrolyte]] and fluid loss. Severe [[hypokalemia]] can lead to [[rhabdomyolysis]], [[prolonged QT interval]], life-threatening [[arrhythmia]], [[syncope]], and [[sudden death]].<ref name="pmid23760993">{{cite journal| author=Hacihamdioglu DO, Fidanci K, Kilic A, Gok F, Topaloglu R| title=QT and JT dispersion and cardiac performance in children with neonatal Bartter syndrome: a pilot study. | journal=Pediatr Nephrol | year= 2013 | volume= 28 | issue= 10 | pages= 1969-74 | pmid=23760993 | doi=10.1007/s00467-013-2517-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760993  }} </ref><ref name="pmid17390745">{{cite journal| author=Scognamiglio R, Negut C, Calò LA| title=Aborted sudden cardiac death in two patients with Bartter's/Gitelman's syndromes. | journal=Clin Nephrol | year= 2007 | volume= 67 | issue= 3 | pages= 193-7 | pmid=17390745 | doi=10.5414/cnp67193 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17390745  }} </ref>
*[[Hypokalemia]] in [[Bartter syndrome]] can be exacerbated by [[electrolytes]] and fluid losses. [[Diarrhea]], [[vomiting]], [[alcohol abuse]], [[cocaine]], or other drugs result in [[electrolyte]] and fluid loss. Severe [[hypokalemia]] can lead to [[rhabdomyolysis]], [[prolonged QT interval]], life-threatening [[arrhythmia]], [[syncope]], and [[sudden death]].<ref name="pmid23760993">{{cite journal| author=Hacihamdioglu DO, Fidanci K, Kilic A, Gok F, Topaloglu R| title=QT and JT dispersion and cardiac performance in children with neonatal Bartter syndrome: a pilot study. | journal=Pediatr Nephrol | year= 2013 | volume= 28 | issue= 10 | pages= 1969-74 | pmid=23760993 | doi=10.1007/s00467-013-2517-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760993  }} </ref><ref name="pmid17390745">{{cite journal| author=Scognamiglio R, Negut C, Calò LA| title=Aborted sudden cardiac death in two patients with Bartter's/Gitelman's syndromes. | journal=Clin Nephrol | year= 2007 | volume= 67 | issue= 3 | pages= 193-7 | pmid=17390745 | doi=10.5414/cnp67193 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17390745  }} </ref>
*[[Glomerular filtration rate]] of <90 mL/min/1.73 m2, sometimes associated with [[proteinuria|overt proteinuria]].
*[[Glomerular filtration rate]] of <90 mL/min/1.73 m2, sometimes associated with [[proteinuria|overt proteinuria]].

Revision as of 17:44, 4 August 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Tayyaba Ali, M.D.[2]

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Kidney failure is a possible complication.

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References

  1. "Bartter syndrome: MedlinePlus Medical Encyclopedia".
  2. Seyberth HW (2008). "An improved terminology and classification of Bartter-like syndromes". Nat Clin Pract Nephrol. 4 (10): 560–7. doi:10.1038/ncpneph0912. PMID 18695706.
  3. 3.0 3.1 3.2 Puricelli E, Bettinelli A, Borsa N, Sironi F, Mattiello C, Tammaro F; et al. (2010). "Long-term follow-up of patients with Bartter syndrome type I and II". Nephrol Dial Transplant. 25 (9): 2976–81. doi:10.1093/ndt/gfq119. PMID 20219833.
  4. Hacihamdioglu DO, Fidanci K, Kilic A, Gok F, Topaloglu R (2013). "QT and JT dispersion and cardiac performance in children with neonatal Bartter syndrome: a pilot study". Pediatr Nephrol. 28 (10): 1969–74. doi:10.1007/s00467-013-2517-5. PMID 23760993.
  5. Scognamiglio R, Negut C, Calò LA (2007). "Aborted sudden cardiac death in two patients with Bartter's/Gitelman's syndromes". Clin Nephrol. 67 (3): 193–7. doi:10.5414/cnp67193. PMID 17390745.
  6. Reungjui S, Roncal CA, Sato W, Glushakova OY, Croker BP, Suga S; et al. (2008). "Hypokalemic nephropathy is associated with impaired angiogenesis". J Am Soc Nephrol. 19 (1): 125–34. doi:10.1681/ASN.2007030261. PMC 2391040. PMID 18178802.


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