Atopic dermatitis history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Atopic dermatitis}} | |||
{{CMG}}; {{AE}} {{S.S}} | {{CMG}}; {{AE}} {{S.S}} | ||
==Overview== | ==Overview== | ||
The most common symptoms of atopic dermatitis include pruritus, distribution of rash | The most common [[symptoms]] of atopic dermatitis include [[pruritus]], distribution of [[rash]] in age-specific patterns, and [[dry skin]]. [[Symptoms]] differ depending on age, stage, race/ethnic group, and geographic location. Patients often have a personal or [[family history]] of [[asthma]] or [[allergic rhinitis]]. [[Patients]] with atopic dermatitis may report a positive history of [[cutaneous]] hyper-reactivity to diverse environmental stimuli and [[Atopy|atopic disorders]]. | ||
==History and Symptoms== | ==History and Symptoms== | ||
===History=== | ===History=== | ||
Patients with atopic dermatitis may have a positive history of:<ref name="pmid23712284">{{cite journal |vauthors=Leung DY |title=New insights into atopic dermatitis: role of skin barrier and immune dysregulation |journal=Allergol Int |volume=62 |issue=2 |pages=151–61 |date=June 2013 |pmid=23712284 |doi=10.2332/allergolint.13-RAI-0564 |url=}}</ref><ref name="pmid97349032">{{cite journal |vauthors=Rudikoff D, Lebwohl M |title=Atopic dermatitis |journal=Lancet |volume=351 |issue=9117 |pages=1715–21 |date=June 1998 |pmid=9734903 |doi=10.1016/S0140-6736(97)12082-7 |url=}}</ref> | [[Patients]] with atopic dermatitis may have a positive history of:<ref name="pmid23712284">{{cite journal |vauthors=Leung DY |title=New insights into atopic dermatitis: role of skin barrier and immune dysregulation |journal=Allergol Int |volume=62 |issue=2 |pages=151–61 |date=June 2013 |pmid=23712284 |doi=10.2332/allergolint.13-RAI-0564 |url=}}</ref><ref name="pmid97349032">{{cite journal |vauthors=Rudikoff D, Lebwohl M |title=Atopic dermatitis |journal=Lancet |volume=351 |issue=9117 |pages=1715–21 |date=June 1998 |pmid=9734903 |doi=10.1016/S0140-6736(97)12082-7 |url=}}</ref> | ||
* | |||
** | *[[Cutaneous]] hyper-reactivity to diverse environmental stimuli including: | ||
** | **Exposure to food and inhalant [[allergens]] | ||
** | **Changes in physical environment (including [[humidity]], [[pollution]], etc.) | ||
** | **[[Irritants]] | ||
** | **[[Microbial|Microbial infection]] | ||
* Atopic march:<ref name="pmid206748192">{{cite journal |vauthors=Spergel JM |title=From atopic dermatitis to asthma: the atopic march |journal=Ann. Allergy Asthma Immunol. |volume=105 |issue=2 |pages=99–106; quiz 107–9, 117 |date=August 2010 |pmid=20674819 |doi=10.1016/j.anai.2009.10.002 |url=}}</ref><ref name="pmid16935684">{{cite journal |vauthors=Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H |title=Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys |journal=Lancet |volume=368 |issue=9537 |pages=733–43 |date=August 2006 |pmid=16935684 |doi=10.1016/S0140-6736(06)69283-0 |url=}}</ref> | **[[Stress]] | ||
*[[Atopic]] march: development of clinical [[signs]] during childhood from atopic dermatitis to [[asthma]] to [[allergic rhinitis]].<ref name="pmid20674819">{{cite journal |vauthors=Spergel JM |title=From atopic dermatitis to asthma: the atopic march |journal=Ann. Allergy Asthma Immunol. |volume=105 |issue=2 |pages=99–106; quiz 107–9, 117 |date=August 2010 |pmid=20674819 |doi=10.1016/j.anai.2009.10.002 |url=}}</ref><ref name="pmid206748192">{{cite journal |vauthors=Spergel JM |title=From atopic dermatitis to asthma: the atopic march |journal=Ann. Allergy Asthma Immunol. |volume=105 |issue=2 |pages=99–106; quiz 107–9, 117 |date=August 2010 |pmid=20674819 |doi=10.1016/j.anai.2009.10.002 |url=}}</ref><ref name="pmid16935684">{{cite journal |vauthors=Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H |title=Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys |journal=Lancet |volume=368 |issue=9537 |pages=733–43 |date=August 2006 |pmid=16935684 |doi=10.1016/S0140-6736(06)69283-0 |url=}}</ref> | |||
**Clinical features of atopic dermatitis usually occur earlier in life. | |||
**[[Asthma]] and [[allergic rhinitis]] usually occur later on in life.<ref name="StänderRopper2021">{{cite journal|last1=Ständer|first1=Sonja|last2=Ropper|first2=Allan H.|title=Atopic Dermatitis|journal=New England Journal of Medicine|volume=384|issue=12|year=2021|pages=1136–1143|issn=0028-4793|doi=10.1056/NEJMra2023911}}</ref> | |||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of | Common [[symptoms]] of atopic dermatitis include:<ref name="DeleuranVestergaard2014">{{cite journal|last1=Deleuran|first1=M.|last2=Vestergaard|first2=C.|title=Clinical heterogeneity and differential diagnosis of atopic dermatitis|journal=British Journal of Dermatology|volume=170|year=2014|pages=2–6|issn=00070963|doi=10.1111/bjd.12933}}</ref><ref name="StänderRopper2021">{{cite journal|last1=Ständer|first1=Sonja|last2=Ropper|first2=Allan H.|title=Atopic Dermatitis|journal=New England Journal of Medicine|volume=384|issue=12|year=2021|pages=1136–1143|issn=0028-4793|doi=10.1056/NEJMra2023911}}</ref> | ||
*Severe [[pruritus]] | |||
*Severe [[pruritus]]: Can cause [[sleep disturbances]] in children<ref name="pmid7633537">{{cite journal |vauthors=Dahl RE, Bernhisel-Broadbent J, Scanlon-Holdford S, Sampson HA, Lupo M |title=Sleep disturbances in children with atopic dermatitis |journal=Arch Pediatr Adolesc Med |volume=149 |issue=8 |pages=856–60 |date=August 1995 |pmid=7633537 |doi= |url=}}</ref><ref name="StänderRopper2021">{{cite journal|last1=Ständer|first1=Sonja|last2=Ropper|first2=Allan H.|title=Atopic Dermatitis|journal=New England Journal of Medicine|volume=384|issue=12|year=2021|pages=1136–1143|issn=0028-4793|doi=10.1056/NEJMra2023911}}</ref> | |||
*Chronic or relapsing skin lesions | *Chronic or relapsing skin lesions | ||
*Distribution of rash on: | *Distribution of rash on: | ||
| Line 28: | Line 30: | ||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of atopic dermatitis include:<ref name="pmid9734903">{{cite journal |vauthors=Rudikoff D, Lebwohl M |title=Atopic dermatitis |journal=Lancet |volume=351 |issue=9117 |pages=1715–21 |date=June 1998 |pmid=9734903 |doi=10.1016/S0140-6736(97)12082-7 |url=}}</ref> | Less common symptoms of atopic dermatitis include:<ref name="pmid9734903">{{cite journal |vauthors=Rudikoff D, Lebwohl M |title=Atopic dermatitis |journal=Lancet |volume=351 |issue=9117 |pages=1715–21 |date=June 1998 |pmid=9734903 |doi=10.1016/S0140-6736(97)12082-7 |url=}}</ref><ref name="StänderRopper2021">{{cite journal|last1=Ständer|first1=Sonja|last2=Ropper|first2=Allan H.|title=Atopic Dermatitis|journal=New England Journal of Medicine|volume=384|issue=12|year=2021|pages=1136–1143|issn=0028-4793|doi=10.1056/NEJMra2023911}}</ref> | ||
* [[Pallor|Facial pallor]] | |||
* [[Dry skin]] especially in winter) | *[[Pallor|Facial pallor]] | ||
* Nonspecific dermatitis of the hands and feet | *[[Dry skin]] especially in winter) | ||
* [[Food intolerance]] | *Nonspecific dermatitis of the hands and feet | ||
* Itch when sweating | *[[Food intolerance]] | ||
*[[Itch]] when sweating | |||
*Difficulty sleeping and diminished productivity has also been reported as atopic dermatitis can cause severe [[pruritus]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:dermatology]] | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shalinder Singh, M.B.B.S.[2]
Overview
The most common symptoms of atopic dermatitis include pruritus, distribution of rash in age-specific patterns, and dry skin. Symptoms differ depending on age, stage, race/ethnic group, and geographic location. Patients often have a personal or family history of asthma or allergic rhinitis. Patients with atopic dermatitis may report a positive history of cutaneous hyper-reactivity to diverse environmental stimuli and atopic disorders.
History and Symptoms
History
Patients with atopic dermatitis may have a positive history of:[1][2]
- Cutaneous hyper-reactivity to diverse environmental stimuli including:
- Atopic march: development of clinical signs during childhood from atopic dermatitis to asthma to allergic rhinitis.[3][4][5]
- Clinical features of atopic dermatitis usually occur earlier in life.
- Asthma and allergic rhinitis usually occur later on in life.[6]
Common Symptoms
Common symptoms of atopic dermatitis include:[7][6]
- Severe pruritus: Can cause sleep disturbances in children[8][6]
- Chronic or relapsing skin lesions
- Distribution of rash on:
- Facial and extensor surfaces in infants and young children
- Flexural lichenification in older children and adults
Less Common Symptoms
Less common symptoms of atopic dermatitis include:[9][6]
- Facial pallor
- Dry skin especially in winter)
- Nonspecific dermatitis of the hands and feet
- Food intolerance
- Itch when sweating
- Difficulty sleeping and diminished productivity has also been reported as atopic dermatitis can cause severe pruritus.
References
- ↑ Leung DY (June 2013). "New insights into atopic dermatitis: role of skin barrier and immune dysregulation". Allergol Int. 62 (2): 151–61. doi:10.2332/allergolint.13-RAI-0564. PMID 23712284.
- ↑ Rudikoff D, Lebwohl M (June 1998). "Atopic dermatitis". Lancet. 351 (9117): 1715–21. doi:10.1016/S0140-6736(97)12082-7. PMID 9734903.
- ↑ Spergel JM (August 2010). "From atopic dermatitis to asthma: the atopic march". Ann. Allergy Asthma Immunol. 105 (2): 99–106, quiz 107–9, 117. doi:10.1016/j.anai.2009.10.002. PMID 20674819.
- ↑ Spergel JM (August 2010). "From atopic dermatitis to asthma: the atopic march". Ann. Allergy Asthma Immunol. 105 (2): 99–106, quiz 107–9, 117. doi:10.1016/j.anai.2009.10.002. PMID 20674819.
- ↑ Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H (August 2006). "Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys". Lancet. 368 (9537): 733–43. doi:10.1016/S0140-6736(06)69283-0. PMID 16935684.
- ↑ 6.0 6.1 6.2 6.3 Ständer, Sonja; Ropper, Allan H. (2021). "Atopic Dermatitis". New England Journal of Medicine. 384 (12): 1136–1143. doi:10.1056/NEJMra2023911. ISSN 0028-4793.
- ↑ Deleuran, M.; Vestergaard, C. (2014). "Clinical heterogeneity and differential diagnosis of atopic dermatitis". British Journal of Dermatology. 170: 2–6. doi:10.1111/bjd.12933. ISSN 0007-0963.
- ↑ Dahl RE, Bernhisel-Broadbent J, Scanlon-Holdford S, Sampson HA, Lupo M (August 1995). "Sleep disturbances in children with atopic dermatitis". Arch Pediatr Adolesc Med. 149 (8): 856–60. PMID 7633537.
- ↑ Rudikoff D, Lebwohl M (June 1998). "Atopic dermatitis". Lancet. 351 (9117): 1715–21. doi:10.1016/S0140-6736(97)12082-7. PMID 9734903.