African trypanosomiasis differential diagnosis

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Overview

Differentiating African trypnosomiasis ffrom otherdiseases

The hemo-lymphatic stage of African trympnosomiasis presents with a rash, fever and anemia and must be differentiated with other diseases such as brucellosis, typhoid fever, malaria, tuberculosis, lymphoma, Dengue, Leptospirosis,

Differential diagnosis of Brucellosis Symptoms Signs Diagnosis Additional Findings
Fever Rash Diarrhea Abdominal pain Weight loss Painful lymphadenopathy Hepatosplenomegaly Arthritis Lab Findings
Brucellosis + + - + + + + + Relative lymphocytosis

Night sweats, often with characteristic smell, likened to wet hay

Typhoid fever + + - + - - + + Decreased hemoglobin Incremental increase in temperature initially and than sustained fever as high as 40°C (104°F)
Malaria + - + + - - + + Microcytosis,

elevated LDH

"Tertian" fever: paroxysms occur every second day
Tuberculosis + + - + + + - + Mild normocytic anemia, hyponatremia, and

hypercalcemia

Night sweats, constant fatigue
Lymphoma + - - + + - + - Increase ESR, increased LDH Night sweats, constant fatigue
Mumps + - - - - + - - Relative lymphocytosis, serum amylase elevated Parotid swelling/tenderness
HIV - - - + + + - + Constant fatigue

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