Patent foramen ovale causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Assistant Editor-In-Chief:Kristin Feeney, B.S. [3]
Overview
The exact cause of patent foramen ovale is still not clear. However, it has been found to occur with increased frequencies in families and might have some genetic component to it. It is hypothesized that closure of the PFO is mediated by the notch 3 gene (on the short arm of chromosome 19), which is also associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome in which there is a high frequency of PFO, migraine, and leukoencephalopathy.[1]
References
- ↑ Angeli, S.; Carrera, P.; Del Sette, M.; Assini, A.; Grandis, M.; Biancolini, D.; Ferrari, M.; Gandolfo, C. (2001). "Very high prevalence of right-to-left shunt on transcranial Doppler in an Italian family with cerebral autosomal dominant angiopathy with subcortical infarcts and leukoencephalopathy". Eur Neurol. 46 (4): 198–201. PMID 11721126.