Binswanger's disease

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Binswanger's disease
ICD-10 I67.3
ICD-9 290.12
DiseasesDB 1405
MeSH D015140

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Binswanger's disease or Subcortical Leukoencephalopathy is a rare form of multi-infarct dementia caused by damage to deep white brain matter. It is characterized by loss of memory and intellectual function and by changes in mood.

Overview

Binswanger's disease is one of the neurological syndromes associated with hypertension.

Risk Factors

Hypertension

Pathophysiology

The histologic findings are diffuse, irregular loss of axons and myelin accompanied by widespread gliosis. Small infarcts may be seen in the frontal lobes. The pathologic mechanism may be damage caused by severe atherosclerosis.

A patient with long term severe hypertension develops progressive dementia.

Diagnosis

CT

CT scans of the head demonstrates a diffuse loss of deep hemispheric white matter.

Prognosis

Binswanger's disease has no known treatment, let alone cure, although drugs used to treat high blood pressure, depression, arrhythmia and low blood pressure are used to treat the condition's symptoms.[1]

References

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