Atherosclerosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Niloofarsadaat Eshaghhosseiny, MD[2]

Atherosclerosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Atherosclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Assessment of Cardiovascular Risk

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocadiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

ACC/AHA Guideline Recommendations

Assessment of cardiovascular risk

Secondary prevention

Case Studies

Case #1

Atherosclerosis causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Atherosclerosis causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Atherosclerosis causes

CDC on Atherosclerosis causes

Atherosclerosis causes in the news

Blogs on Atherosclerosis causes

Directions to Hospitals Treating Atherosclerosis

Risk calculators and risk factors for Atherosclerosis causes

Overview

Atherosclerosis may be caused by inflamation,immunity or infection.Atherosclerosis is a disease with multiple genetic and environmental contributions. To review risk factors for the development of atherosclerosis, click here.

Causes

Life-threatening Causes

  • Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.complications resulting from untreated atherosclerosis is common.
  • Atherosclerosis is a life-threatening cause of acute cronary syndrome and stroke.

Common Causes

Common causes of atherosclerosis may include:

  • Immunity
  • Inflamation
  • Infections,such as geram negative sepsis,can cause type 2 acute cronary syndrome.[1]
  • Smoking
  • HTN
  • HLP
  • DM
  • Kidney disease
  • Adiposity

Less Common Causes

Less common causes of [disease name] include:

  • [Cause1]
  • [Cause2]
  • [Cause3]

Genetic Causes

  • Atherosclerosis can caused by expression in the PCSK9 gene.[2]
  • Mutation one of the three genes below can cause familal hypercholesterolemia:LDLR,APOB3,PCSK9.[3]
  • In human nearly 40 quantitative trait loci have been found for atherosclerosis.[4]

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes


Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

  • Cause 1
  • Cause 2
  • Cause 3
  • Cause 4
  • Cause 5
  • Cause 6
  • Cause 7
  • Cause 8
  • Cause 9
  • Cause 10

References

  1. Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V; et al. (2018). "Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week". J Am Coll Cardiol. 72 (17): 2071–2081. doi:10.1016/j.jacc.2018.08.1043. PMC 6196735. PMID 30336831.
  2. Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S; et al. (2012). "Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels". Atherosclerosis. 220 (2): 381–6. doi:10.1016/j.atherosclerosis.2011.11.026. PMID 22176652.
  3. Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ; et al. (2015). "Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome". Eur Heart J. 36 (9): 560–5. doi:10.1093/eurheartj/ehu058. PMID 24585268.
  4. Chen Y, Rollins J, Paigen B, Wang X (2007). "Genetic and genomic insights into the molecular basis of atherosclerosis". Cell Metab. 6 (3): 164–79. doi:10.1016/j.cmet.2007.07.001. PMC 2083632. PMID 17767904.

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