Non-Hodgkin lymphoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Non-Hodgkin lymphoma may be classified into subtypes according to updated WHO classification and rate of growth.
Classification
A. Updated WHO classification
- B-cell neoplasms
- T-cell and putative NK-cell neoplasms
B-cell neoplasms | T-cell and putative NK-cell neoplasms |
---|---|
Precursor B-cell neoplasm | Precursor T-cell neoplasm |
Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) | Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) |
Mature B-cell neoplasms | Peripheral T-cell and NK-cell neoplasms |
Chronic lymphocytic leukemia / small lymphocytic lymphoma | T-cell CLL / prolymphocytic leukemia |
Monoclonal B-cell lymphocytosis | |
B-cell prolymphocytic leukemia | T-cell granular lymphocytic leukemia |
Splenic marginal zone lymphoma (± villous lymphocytes)
Splenic B-cell lymphoma/leukemia, unclassifiable 1. Splenic diffuse re pulp small B-cell lymphoma 2. Hairy cell leukemia-variant |
Extranodal T-/NK-cell lymphoma, nasal type |
Hairy cell leukemia | Enteropathy-type intestinal T-cell lymphoma |
Lymphoplasmacytic lymphoma | Mycosis fungoides / Sézary syndrome |
Monoclonal gammopathy of undetermined significance (MGUS),
2. IgG/A |
|
µ heavy-chain disease
ɣ heavy-chain disease α heavy-chain disease |
|
Plasma cell myeloma (multiple myloma) | |
Solitary plasmacytoma of bone | |
Extraosseous plasmacytoma | |
Monoclonal immunoglobulin deposition diseases | |
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) | |
Nodal marginal zone B-cell lymphoma (± monocytoid B-cells)
pediatric Nodal marginal zone B-cell lymphoma |
Angioimmunoblastic T-cell lymphoma |
Follicular lymphoma
In situ follicular neoplasia Duodenal-type follicular lymphoma Pediatric-type follicular lymphoma |
Hepatosplenic gamma / delta T-cell lymphoma |
Large B-cell lymphoma with IRF4 rearrangement | |
Primary cutaneous follicle center lymphoma | Subcutaneous panniculitis-like T-cell lymphoma |
Mantle cell lymphoma
In situ mantle cell neoplasia |
Peripheral T-cell lymphoma, not otherwise characterized |
Diffuse large B-cell lymphoma (DLBCL), NOS
Germinal center B-cell type Activated B-cell type Primary DLBCL of the central nervous system (CNS) Primary cutaneous DLBCL, leg type DLBCL associated with chronic inflammation HHV81 DLBCL, NOS |
Anaplastic large cell lymphoma, primary systemic type |
T-cell/histiocyte-rich large B-cell lymphoma | |
EBV1 DLBCL, NOS
EBV1 mucocutaneous ulcer |
Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+) |
Lymphomatoid granulomatosis | |
Primary mediastinal (thymic) large B-cell lymphoma | Aggressive NK-cell leukemia |
Intravascular large B-cell lymphoma | |
ALK1 large B-cell lymphoma | |
Plasmablastic lymphoma | |
Primary effusion lymphoma | |
Burkitt lymphoma
Burkitt-like lymphoma with 11q aberration |
Anaplastic large cell lymphoma, primary cutaneous type |
High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements
High-grade B-cell lymphoma, NOS* |
|
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma |
B. Classification based on rate of growth
- Non-Hodgkin lymphoma may be classified based on rate of growth into 2 groups:[2]
- Low-grade or Indolent lymphoma
- High-grade or Aggressive lymphoma
Grade | Description |
---|---|
Low-grade or Indolent lymphoma |
|
High-grade or Aggressive lymphoma |
|
Non-Hodgkin's Lymphoma | ||
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References
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
- ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".