Thrombotic thrombocytopenic purpura risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Risk Factors

Common Risk Factors

Common risk factors in the development of TTP may be occupational, environmental, genetic, and viral.

Common risk factors in the development of TTP include:[1][2]

  • Black ethnicity
  • Female gender
  • SLE
  • Obesity
  • Pregnancy (third tremestr)
  • Cancer therapies

Less Common Risk Factors

Less common risk factors in the development of TTP include:

  • HIV infection
  • Bone marrow transplantation
  • Antiplatelet agents
  • Quinine

References

  1. Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P (2016). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLoS ONE. 11 (7): e0156679. doi:10.1371/journal.pone.0156679. PMC 4934773. PMID 27383202.
  2. Nicol, Kathleen K.; Shelton, Brent J.; Knovich, Mary Ann; Owen, John (2003). "Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura". American Journal of Hematology. 74 (3): 170–174. doi:10.1002/ajh.10418. ISSN 0361-8609.

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