Differentiating Scleroderma from other diseases
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]
Overview
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
OR
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
Differentiating X from other Diseases
- [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
- [Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].
- As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].
Preferred Table
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Physical examination | |||||||||||||||||
Lab Findings | Imaging | Histopathology | ||||||||||||||||
Skin thickening | Raynaud phenomenon | Dysphagia | Dyspnea | Indurated skin | Sclerodactyly | Telangiectasia | Abdominal distension | Autoantibodies | Anemia | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | |||||
Scleroderma | Limited cutaneous systemic sclerosis (CREST syndrome) | |||||||||||||||||
Diffuse cutaneous systemic sclerosis | ||||||||||||||||||
Systemic diseases | Scleroderma | |||||||||||||||||
Scleromyxedema | ||||||||||||||||||
Amyloidosis | ||||||||||||||||||
Eosinophilic fasciitis | ||||||||||||||||||
Chronic graft-versus-host disease | ||||||||||||||||||
Drug induced scleroderma | ||||||||||||||||||
Scleroderma overlap syndromes | Systemic lupus erythematosus | |||||||||||||||||
Dermatomyositis | ||||||||||||||||||
Rheumatoid arthritis | ||||||||||||||||||
Endocrine disorders | Diabetes mellitus (diabetic cheiroarthropathy) | |||||||||||||||||
Myxedema due to hypothyroidism | ||||||||||||||||||
POEMS syndrome | ||||||||||||||||||
Renal diseases | Nephrogenic systemic fibrosis |