Primary biliary cirrhosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
The majority of patients with early primary biliary cirrhosis are asymptomatic. The hallmark of primary biliary cirrhosis is pruritis, worse at night. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
- The majority of patients with early primary biliary cirrhosis are asymptomatic.[1]
- The hallmark of primary biliary cirrhosis is pruritis, worse at night. The most common symptoms of primary biliary cirrhosis include fatigue, pruritis, and jaundice.
- Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History
Patients with primary biliary cirrhosis may have a positive history of:[2]
- Pruritis, worse at night
- Fatigue
- Daytime somnolence[3]
Common Symptoms
Common symptoms of primary biliary cirrhosis include:[2]
- Fatigue
- Pruritis
- Jaundice
- Right upper quadrant pain (10%)[4]
Less Common Symptoms
Less common symptoms of primary biliary cirrhosis include:[5]
- Variceal bleeding
- Abdominal distension
- Hepatic encephalopathy
References
- ↑ Prince M, Chetwynd A, Newman W, Metcalf JV, James OF (2002). "Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years". Gastroenterology. 123 (4): 1044–51. PMID 12360466.
- ↑ 2.0 2.1 Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A; et al. (1990). "The demography of primary biliary cirrhosis in Ontario, Canada". Hepatology. 12 (1): 98–105. PMID 2197212.
- ↑ Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D (2006). "Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence". Hepatology. 44 (1): 91–8. doi:10.1002/hep.21230. PMID 16800007.
- ↑ Laurin JM, DeSotel CK, Jorgensen RA, Dickson ER, Lindor KD (1994). "The natural history of abdominal pain associated with primary biliary cirrhosis". Am J Gastroenterol. 89 (10): 1840–3. PMID 7942679.
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.