Primary biliary cirrhosis surgery

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Primary Biliary Cirrhosis Microchapters


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]


The mainstay of treatment for primary biliary cirrhosis is medical therapy. Surgery is usually reserved for patients with either decompensated cirrhosis and endstage liver failure who do not show any improvement with medical therapy.


Indications for liver transplantation include:[1][2][3][4][5]




  1. 1.0 1.1 Carbone M, Neuberger J (2011). "Liver transplantation in PBC and PSC: indications and disease recurrence". Clin Res Hepatol Gastroenterol. 35 (6–7): 446–54. doi:10.1016/j.clinre.2011.02.007. PMID 21459072.
  2. 2.0 2.1 Mucha, Krzysztof (2014). "Primary Biliary Cirrhosis in the Era of Liver Transplantation". Annals of Transplantation. 19: 488–493. doi:10.12659/AOT.890753. ISSN 2329-0358.
  3. Taniguchi M (2012). "Liver transplantation in the MELD era--analysis of the OPTN/UNOS registry". Clin Transpl: 41–65. PMID 23721009.
  4. Mazzaferro, Vincenzo; Bhoori, Sherrie; Sposito, Carlo; Bongini, Marco; Langer, Martin; Miceli, Rosalba; Mariani, Luigi (2011). "Milan criteria in liver transplantation for hepatocellular carcinoma: An evidence-based analysis of 15 years of experience". Liver Transplantation. 17 (S2): S44–S57. doi:10.1002/lt.22365. ISSN 1527-6465.
  5. Purohit, Treta (2015). "Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy". World Journal of Hepatology. 7 (7): 926. doi:10.4254/wjh.v7.i7.926. ISSN 1948-5182.
  6. Purohit, Treta (2015). "Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy". World Journal of Hepatology. 7 (7): 926. doi:10.4254/wjh.v7.i7.926. ISSN 1948-5182.
  7. MacQuillan GC, Neuberger J (2003). "Liver transplantation for primary biliary cirrhosis". Clin Liver Dis. 7 (4): 941–56, ix. PMID 14594139.
  8. Tinmouth J, Tomlinson G, Heathcote EJ, Lilly L (2002). "Benefit of transplantation in primary biliary cirrhosis between 1985-1997". Transplantation. 73 (2): 224–7. PMID 11821734.
  9. Raczyńska J, Habior A, Pączek L, Foroncewicz B, Pawełas A, Mucha K (2014). "Primary biliary cirrhosis in the era of liver transplantation". Ann. Transplant. 19: 488–93. doi:10.12659/AOT.890753. PMID 25262831.
  10. Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P; et al. (2003). "Model for end-stage liver disease (MELD) and allocation of donor livers". Gastroenterology. 124 (1): 91–6. doi:10.1053/gast.2003.50016. PMID 12512033.
  11. Gilroy RK, Lynch SV, Strong RW, Kerlin P, Balderson GA, Stuart KA, Crawford DH (2000). "Confirmation of the role of the Mayo Risk Score as a predictor of resource utilization after orthotopic liver transplantation for primary biliary cirrhosis". Liver Transpl. 6 (6): 749–52. doi:10.1053/jlts.2000.9746. PMID 11084062.
  12. Dubel L, Farges O, Bismuth H, Sebagh M, Homberg JC, Johanet C (1995). "Kinetics of anti-M2 antibodies after liver transplantation for primary biliary cirrhosis". J. Hepatol. 23 (6): 674–80. PMID 8750166.
  13. Ciesek S, Becker T, Manns MP, Strassburg CP (2010). "Anti-parietal cell autoantibodies (PCA) in primary biliary cirrhosis: a putative marker for recurrence after orthotopic liver transplantation?". Ann Hepatol. 9 (2): 181–5. PMID 20526013.
  14. Schreibman I, Regev A (2006). "Recurrent primary biliary cirrhosis after liver transplantation--the disease and its management". MedGenMed. 8 (2): 30. PMC 1785210. PMID 16926769.

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