Large cell carcinoma of the lung overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Historical Perspective
Classification
According to the World Health Organization (WHO), large cell carcinoma of the lung can be classified into 6 sub-types: giant-cell carcinoma of the lung, basaloid large cell carcinoma of the lung, clear cell carcinoma of the lung, lymphoepithelioma-like carcinoma of the lung, large-cell lung carcinoma with rhabdoid phenotype, and large cell neuroendocrine carcinoma of the lung
Pathophysiology
On gross pathology, large cell carcinoma of the lung is characterized by
On micropathology, large cell carcinoma of the lung is characterized by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin.
Causes
The most important cause in the development of large cell carcinoma of the lung is cigarette smoking.
Differentiating Large Cell Carcinoma of the Lung from other Diseases
Epidemiology and Demographics
Large cell lung cancer accounts for 5% and 10% of all lung cancers.