Large cell carcinoma of the lung other imaging findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Other imaging findings of large cell carcinoma of the lung, include: PET/CT, and pulmonary angiography.[1][2]

Other Imaging Findings

PET/CT

  • PET scanning with the tracer fluorine-18 (F-18) fluorodeoxyglucose (FDG), called FDG-PET, is widely used in the diagnosis of squamous cell carcinoma of the lung, for the following reasons:[1][2]
  • General follow-up
  • Characterization of treatment response
  • Staging modality (in the risk of missing occult disease)
  • On PET/CT, findings of large cell carcinoma of the lung, include:[2]
  • The CT scan demonstrates abnormalities such as a lung nodule or enlarged lymph nodes. Whereas, the PET scan reveals increased metabolism in structures which contain rapidly growing cancer cells
  • Intense radiolabeling of tissues with high glucose uptake, such as the brain, the liver, and malignant tumor cells.
  • On gallium-67-scan, characteristic findings of non-small cell lung cancer, include:[2]
  • Gallium uptake is mainly dependent on tumor size (limited practical value)

Pulmonary Angiography

  • On pulmonary angiography, findings of large cell carcinoma of the lung, include:[3]
  • Evaluation of central pulmonary artery invasion

References

  1. 1.0 1.1 Shim SS, Lee KS, Kim BT, Chung MJ, Lee EJ, Han J, Choi JY, Kwon OJ, Shim YM, Kim S (2005). "Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging". Radiology. 236 (3): 1011–9. doi:10.1148/radiol.2363041310. PMID 16014441.
  2. 2.0 2.1 2.2 2.3 Steinert HC (2011). "PET and PET-CT of lung cancer". Methods Mol. Biol. 727: 33–51. doi:10.1007/978-1-61779-062-1_3. PMID 21331927.
  3. Delarue NC, Sanders DE, Silverberg SA (1970). "Complementary value of pulmonary angiography and mediastinoscopy in individualizing treatment for patients with lung cancer". Cancer. 26 (6): 1370–8. PMID 5483666.


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