Renal cell carcinoma causes

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Overview

The causes of renal cell carcinoma include von hippel lindau (VHL), hereditary paragangliomas, leiomyomatosis, birt-hogg-dube syndrome, and several other genetic factors.

Causes

Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.

The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:

Sporadic Forms of Renal Cell Carcinoma

Sporadic Forms of Renal Cell Carcinoma[1]
Histologic Appearance Incidence Gene Frequency
Conventional (Clear Cell) 75 VHL 60 %
Papillary 12 MET
TFE3
13 %
< 1 %
Chromophobe 4
Oncocytoma 4
Collecting Duct < 1
Unclassified 3 - 5
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90

Hereditary Forms of Renal Cell Carcinoma

Hereditary Forms of Renal Cell Carcinoma[1]
Syndrome Associated Gene Common Histological Appearance
VHL Disease VHL Conventional (Clear Cell)
FCRC Chromosome 3p translocation Conventional (Clear Cell)
Hereditary Paraganglioma SDHB Conventional (Clear Cell)
HPRC MET Papillary
HLRCC FH Papillary
Birt-Hogg-Dube Syndrome BHD Chromophobe / Oncocytoma
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90

References

  1. 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.