Renal cell carcinoma causes
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Overview
The causes of renal cell carcinoma include von hippel lindau (VHL), hereditary paragangliomas, leiomyomatosis, birt-hogg-dube syndrome, and several other genetic factors.
Causes
Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.
The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:
Sporadic Forms of Renal Cell Carcinoma
Histologic Appearance | Incidence | Gene | Frequency |
Conventional (Clear Cell) | 75 | VHL | 60 % |
Papillary | 12 | MET TFE3 |
13 % < 1 % |
Chromophobe | 4 | ||
Oncocytoma | 4 | ||
Collecting Duct | < 1 | ||
Unclassified | 3 - 5 |
Hereditary Forms of Renal Cell Carcinoma
Syndrome | Associated Gene | Common Histological Appearance |
VHL Disease | VHL | Conventional (Clear Cell) |
FCRC | Chromosome 3p translocation | Conventional (Clear Cell) |
Hereditary Paraganglioma | SDHB | Conventional (Clear Cell) |
HPRC | MET | Papillary |
HLRCC | FH | Papillary |
Birt-Hogg-Dube Syndrome | BHD | Chromophobe / Oncocytoma |
References
- ↑ 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.