Renal cell carcinoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul; Serge Korjian; Rim Halaby, M.D. [2]
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Overview
In 2011, the age-adjusted prevalence of kidney cancer was 85.9 per 100,000 in the United States, the incidence was 15.28 per 100,000 persons. The male to female ratio is approximately 2 to 1. The median age of presentation is typically 60 years old.
Epidemiology
Prevalence
- Renal cell carcinoma accounts for approximately 2-3% of all malignant tumors in the adult population.[1] Most cases of renal cell carcinoma are sporadic; whereas only approximately 2-3% of all cases are familial, most of which have an autosomal-dominant pattern of inheritance.[1]
- In the United States, the age-adjusted prevalence of kidney cancer is 85.9 per 100,000 in 2011.[2]
- In 2012, there were an estimated 375,925 people living with kidney and renal pelvis cancer in the United States.[3]
Incidence
- The delay-adjusted incidence of kidney cancer in 2011 was estimated to be 15.88 per 100,000 persons in the United States.[2]
- In 2011, the age-adjusted incidence of kidney cancer was 15.28 per 100,000 persons in the United States.[2]
- Estimated new cases and deaths from renal cell (kidney and renal pelvis) cancer in the United States in 2015 are 61,560 and 14,080 respectively. [4]
Age
- The median age of presentation is typically 60 years.[1]
- While the overall age-adjusted incidence of kidney cancer in the United States between 2007 and 2011 is 15.5 per 100,000, the age-adjusted incidence of kidney cancer by age category is:[2]
- Under 65 years: 8.3 per 100,000
- 65 and over: 65 per 100,000
Gender
- Renal cell carcinomas is considered the 7th most common cancer in men and the 9th most common cancer in women.
- The male to female ratio is approximately 2 to 1.[1] The ratio increases dramatically increases in sporadic cases of papillary renal cell carcinomas, reaching a 5 to 1 ratio.[5]
- In the United States, the age-adjusted prevalence of kidney cancer by gender in 2011 is:[2]
- In males: 113.2 per 100,000
- In females: 63.3 per 100,000
- In the United States, the delay-adjusted incidence of kidney cancer by gender in 2011 is:[2]
- In males: 21.84 per 100,000 persons
- In females: 10.81 per 100,000 persons
- In the United States, the age-adjusted incidence of kidney cancer by gender in 2011 is:[2]
- In males: 21.02 per 100,000 persons
- In females: 10.4 per 100,000 persons
- Shown below is an image depicting the delay-adjusted incidence and observed incidence of kidney cancer by gender and race in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[2]
Race
- Shown below is a table depicting the age-adjusted prevalence of kidney cancer by race in 2011 in the United States.[2]
| All Races | White | Black | Asian/Pacific Islander | Hispanic | |
| Age-adjusted prevalence | 85.9 per 100,000 | 90.8 per 100,000 | 91.3 per 100,000 | 46.7 per 100,000 | 86.7 per 100,000 |
- Shown below is an image depicting the incidence of kidney cancer by race in the United States between 1975 and 2011.[2]
API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native
References
- ↑ 1.0 1.1 1.2 1.3 Rini BI, Campbell SC, Escudier B (2009). "Renal cell carcinoma". Lancet. 373 (9669): 1119–32. doi:10.1016/S0140-6736(09)60229-4. PMID 19269025.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
- ↑ National Cancer Institute.Surveillance, Epidemiology, and End Results Program 2015.http://seer.cancer.gov
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.