Sulbutiamine

Sulbutiamine

Clinical data
Synonyms	Arcalion, bisibuthiamine, youvitan
Routes of administration	Oral
ATC code	A11DA02 (WHO)
Pharmacokinetic data
Elimination half-life	5 hours
Excretion	Renal
Identifiers
IUPAC name [4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl- amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl- formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3- yl]disulfanyl-pent-3-enyl] 2-methylpropanoate
CAS Number	3286-46-2
PubChem CID	71124
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C32H46N8O6S2
Molar mass	702.89 g/mol
3D model (JSmol)	Interactive image
SMILES CC1=NC=C(C(=N1)N)CN(C=O)C(=C (CCOC(=O)C(C)C)SSC(=C(C)N(CC2= CN=C(N=C2N)C)C=O)CCOC(=O)C(C)C)C

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Overview

Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B₁). It is indicated for the treatment of asthenia. Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats and patients of schizophrenia suggests that it is a nootropic.

Effects

Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.

Dosage

Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg, which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.

External links

• "New Drugs that Make you Smart" by John Morgenthaler