Sulbutiamine

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Sulbutiamine
Clinical data
SynonymsArcalion, bisibuthiamine, youvitan
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Elimination half-life5 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC32H46N8O6S2
Molar mass702.89 g/mol
3D model (JSmol)

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Overview

Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B1). It is indicated for the treatment of asthenia.[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats[2] and patients of schizophrenia[2] suggests that it is a nootropic.

Effects

Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.[3]

Dosage

Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.

References

  1. Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia". J Assoc Physicians India. 51: 891&ndash, 5. PMID 14710977.
  2. 2.0 2.1 2.2 Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task". Prog Neuropsychopharmacol Biol Psychiatry. 29 (6): 928&ndash, 35. PMID 15951087.
  3. http://www.serdiapharma.com/about/arcalion.asp

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