Non-Hodgkin lymphoma (differentiating types of NHL)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Non-Hodgkin lymphoma (differentiating types of NHL)
Differentiating different types of Non-Hodgkin lymphoma. Gold standard for differentiation different types of Non-Hodgkin lymphoma is Biopsy.
Category | Disease | Etiology | Clinical manifestations | Paraclinical findings | Associated findings | ||||||||||
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Lab findings | |||||||||||||||
Symptoms | Signs | CBC | Immunochemistry | Histopathology | |||||||||||
Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | |||||||
Hodgkin's Lymphoma[1][2] |
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Non-Hodgkin's Lymphoma | |||||||||||||||
Diffuse large B cell lymphoma |
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- | + | + |
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↓ | ↓ | Nl to ↓ |
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Centroblastic
Immunoblastic
Anaplastic
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B Cell Lymphoma | Mantle cell lymphoma |
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Abdominal distention |
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↓ | Nl to ↓ |
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B-lymphoblastic leukemia/lymphoma |
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+ | – | – | – |
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↓ | ↓ | Nl to ↓ |
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Follicular lymphoma |
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Only in 20% of patients: | + | + | ± |
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↓ | ↓ | Nl to ↓ |
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Burkitt lymphoma |
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B cell chronic lymphocytic leukemia/small lymphocytic lymphoma |
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Marginal zone lymphoma | Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type |
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Splenic marginal zone lymphoma |
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Nodal marginal zone B-cell lymphoma |
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+ |
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Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia) |
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Hairy cell leukemia |
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Category | Disease | Etiology | Constitutional symptoms | Rash | Abdominal pain | Diarrhea | Mass | Other | WBC | Hb | Plt | Immunochemistry | Histopathology | Associated findings | |
T cell lymphoma | Precursor T-cell lymphoblastic leukemia/lymphoma |
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Adult T cell leukemia/lymphoma |
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Anaplastic large cell lymphoma |
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Cutaneous T-cell lymphoma | Mycosis fungoides / Sézary syndrome |
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Peripheral T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma |
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Hepatosplenic gamma-delta T-cell lymphoma |
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Enteropathy-type intestinal T-cell lymphoma |
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Extranodal T-cell lymphoma, nasal type |
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Angioimmunoblastic T-cell lymphoma |
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Peripheral T-cell lymphoma, unspecified |
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- ↑ Buri C, Körner M, Schärli P, Cefai D, Uguccioni M, Mueller C; et al. (2001). "CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease". Blood. 97 (6): 1543–8. PMID 11238088.
- ↑ Zahn M, Marienfeld R, Melzner I, Heinrich J, Renner B, Wegener S; et al. (2017). "A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells". Blood. 129 (11): 1480–1490. doi:10.1182/blood-2016-06-720516. PMID 28082443.