Amyloidosis natural history, complications and prognosis

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Classification • Primary amyloidosis • Secondary amyloidosis • Familial amyloidosis • Wild-type (senile) amyloidosis • Cardiac amyloidosis • Beta-2 microglobulin related amyloidosis • Gelsolin related amyloidosis • Lysozyme amyloid related amyloidosis • Leucocyte cell-derived chemotaxin 2 related amyloidosis • Fibrinogen A alpha-chain associated amyloidosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The complications of amyloidosis include hyposplenism, malabsorbtion syndrome, myopathy, proximal renal tubular acidosis and renal failure. The severity the disease depends on the organs that are affected. When the heart and kidney are involved, it may lead to organ failure and death.

Complications

Possible complications of amyloidosis include:

• Hyposplenism
• Malabsorption syndrome
• Myopathy
• Proximal renal tubular acidosis
• Renal failure
• Vascular hemostatic disorder
• Chronic brain failure
• Nephrotic syndrome
• Myocarditis
• Restrictive cardiomyopathy
• Pulmonary fibrosis
• Autonomic neuropathy
• Pericardial effusion
• Congestive heart failure
• Endocrine failure (hormonal disorder)
• Respiratory failure
• Hypogonadic hypogonadism
• Death

Prognosis

The severity the disease depends on the organs that are affected. When the heart and kidney are involved, it may lead to organ failure and death. Body-wide (systemic) involvement can lead to death in 1 to 3 years.