Diabetes mellitus surgery: Difference between revisions
(New page: {{Diabetes mellitus }} {{CMG}}; '''Associate Editor(s)-In-Chief:''' Priyamvada Singh, M.B.B.S. [mailto:psingh@perfuse.org]; {{CZ}} ==Overview== ===Cures for type 2 di...) |
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Type 2 diabetes can be cured by one type of [[gastric bypass surgery]] in 80-100% of severely obese patients. The effect is not due to weight loss because it usually occurs within days of surgery, which is before significant weight loss occurs. The pattern of secretion of gastrointestinal hormones is changed by the bypass and removal of the [[duodenum]] and proximal [[jejunum]], which together form the upper (proximal) part of the [[small intestine]].<ref name=pmid12409659>{{cite journal | Type 2 diabetes can be cured by one type of [[gastric bypass surgery]] in 80-100% of severely obese patients. The effect is not due to weight loss because it usually occurs within days of surgery, which is before significant weight loss occurs. The pattern of secretion of gastrointestinal hormones is changed by the bypass and removal of the [[duodenum]] and proximal [[jejunum]], which together form the upper (proximal) part of the [[small intestine]].<ref name=pmid12409659>{{cite journal | ||
|last=Rubino |first=F |coauthors=Gagner M | |last=Rubino |first=F |coauthors=Gagner M | ||
Revision as of 14:03, 15 September 2011
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Diabetes mellitus Main page |
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Patient Information |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]
Overview
Type 2 diabetes can be cured by one type of gastric bypass surgery in 80-100% of severely obese patients. The effect is not due to weight loss because it usually occurs within days of surgery, which is before significant weight loss occurs. The pattern of secretion of gastrointestinal hormones is changed by the bypass and removal of the duodenum and proximal jejunum, which together form the upper (proximal) part of the small intestine.[1] One hypothesis is that the proximal small intestine is dysfunctional in type 2 diabetes; its removal eliminates the source of an unknown hormone that contributes to insulin resistance.[2] This surgery has been widely performed on morbidly obese patients and has the benefit of reducing the death rate from all causes by up to 40%.[3] A small number of normal to moderately obese patients with type 2 diabetes have successfully undergone similar operations.[4][5]
References
- ↑ Rubino, F (2002). "Potential of surgery for curing type 2 diabetes mellitus". Ann. Surg. 236 (5): 554–9. ISSN 0003-4932. PMID 12409659. Unknown parameter
|coauthors=ignored (help) - ↑ Rubino, F (2006). "The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes". Ann. Surg. 244 (5): 741–9. PMID 17060767. Unknown parameter
|coauthors=ignored (help) - ↑ Adams, TD (2007). "Long-term mortality after gastric bypass surgery". N. Engl. J. Med. 357 (8): 753–61. doi:10.1056/NEJMoa066603. ISSN 0028-4793. PMID 17715409. Unknown parameter
|coauthors=ignored (help) - ↑ Cohen, RV (2007). "Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22-34 kg/m2: a report of 2 cases". Surg Obes Relat Dis. 3 (2): 195–7. doi:10.1016/j.soard.2007.01.009. PMID 17386401. Unknown parameter
|coauthors=ignored (help) - ↑ Vasonconcelos, Alberto (2007-09-01). "Could type 2 diabetes be reversed using surgery?". New Scientist (2619): 11–13. Retrieved 2007-09-26. Check date values in:
|date=(help)