Neurofibroma differential diagnosis: Difference between revisions
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* [[S-100]](stains only fat cells) | * [[S-100]](stains only fat cells) | ||
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|'''Ganglioneuroma''' | |||
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Revision as of 15:41, 22 April 2019
Neurofibroma Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Neurofibroma differential diagnosis On the Web |
American Roentgen Ray Society Images of Neurofibroma differential diagnosis |
Risk calculators and risk factors for Neurofibroma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
Neurofibroma must be differentiated from schwannoma, dermatofibrosarcoma protuberans (DFSP), ganglioneuroma, and melanocytic nevus.
Differential Diagnosis
Neurofibroma must be differentiated from:[1][2][3]
- Schwannoma
- Dermatofibrosarcoma protuberans (DFSP)
- Ganglioneuroma
- Dermal neurotized melanocytic nevus
- Myxoid liposarcoma
- Solitary circumscribed neuroma (palisaded encapsulated neuroma)
- Traumatic neuroma
- Superficial angiomyxoma
- Nerve sheath myxoma
- Malignant peripheral nerve sheath tumor (MPNST): has marked atypia and increased mitotic activity, may have necrosis
- Spindle cell lipoma
- Leiomyoma: has cigar-shaped nuclei, S100 negative, positive for smooth muscle actin and desmin
- Inflammatory myofibroblastic tumor: reactive spindle cells in inflammatory background
- Acrochorda (aka skin tag or soft fibroma)
Disease entity | Histopathological findings | Immunohistochemical staining | Risk factors | Common site of involvement | Other associated features |
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Neurofibroma |
Neurofibroma with degenerative atypia ("ancient change") has following microscopic features:
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Positive for:
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Schwannoma |
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Positive for:
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Palisaded encapsulated neuroma |
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Positive for:
Negative for: |
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Traumatic neuroma |
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Neurotized Melanocytic Nevus |
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Positive for:
Negative for:
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Cutaneous Myxoma (Superficial angiomyxoma) |
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Positive for: |
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Nerve sheath myxoma |
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Positive for: | |||
Malignant peripheral nerve sheath tumor |
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Positive for:
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Dermatofibrosarcoma protuberans (DFSP) |
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Strongly positive for:
Negative for: |
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Spindle cell lipoma |
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Positive for:
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Ganglioneuroma | |||||
References
- ↑ Neurofibroma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Neurofibroma#cite_note-pmid15486243-2 Accessed on November 17, 2015
- ↑ http://surgpathcriteria.stanford.edu/peripheral-nerve/neurofibroma/
- ↑ http://surgpathcriteria.stanford.edu/peripheral-nerve/neurofibroma/