Ovarian germ cell tumor epidemiology and demographics: Difference between revisions

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* These [[Tumor|tumors]] comprised less than 1% of [[malignant]] [[ovarian]] [[germ cell]] [[tumors]].<ref name="JiaoXiang2010">{{cite journal|last1=Jiao|first1=Lan-zhou|last2=Xiang|first2=Yang|last3=Feng|first3=Feng-zhi|last4=Wan|first4=Xi-run|last5=Zhao|first5=Jun|last6=Cui|first6=Quan-cai|last7=Yang|first7=Xiu-yu|title=Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma|journal=International Journal of Gynecological Cancer|volume=20|issue=2|year=2010|pages=299–302|issn=1048-891X|doi=10.1111/IGC.0b013e3181cc2526}}</ref>
* These [[Tumor|tumors]] comprised less than 1% of [[malignant]] [[ovarian]] [[germ cell]] [[tumors]].<ref name="JiaoXiang2010">{{cite journal|last1=Jiao|first1=Lan-zhou|last2=Xiang|first2=Yang|last3=Feng|first3=Feng-zhi|last4=Wan|first4=Xi-run|last5=Zhao|first5=Jun|last6=Cui|first6=Quan-cai|last7=Yang|first7=Xiu-yu|title=Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma|journal=International Journal of Gynecological Cancer|volume=20|issue=2|year=2010|pages=299–302|issn=1048-891X|doi=10.1111/IGC.0b013e3181cc2526}}</ref>
===Age===
===Age===
*Although The malignant germ cell tumors may be present during the infancy, the has been reported between the age of 15 and 19 years where dysgerminoma is the most common type observed.
*In those who are aged 9 years old or younger, the incidence has been reported to be 0.1 per 100,000 girls.<ref name="BrookfieldCheung2009">{{cite journal|last1=Brookfield|first1=Kathleen F.|last2=Cheung|first2=Michael C.|last3=Koniaris|first3=Leonidas G.|last4=Sola|first4=Juan E.|last5=Fischer|first5=Anne C.|title=A Population-Based Analysis of 1037 Malignant Ovarian Tumors in the Pediatric Population|journal=Journal of Surgical Research|volume=156|issue=1|year=2009|pages=45–49|issn=00224804|doi=10.1016/j.jss.2009.03.069}}</ref>
*In those between the age of 10 to 19 years old, the incidence has been reported to be 1.1 per 100,000 girls.
*Another peak incidence of these tumors has been reported among those aged 65 years old or older where teratoma is the most common type observed.<ref>{{Cite journal
| author = [[I. dos Santos Silva]] & [[A. J. Swerdlow]]
| title = Ovarian germ cell malignancies in England: epidemiological parallels with testicular cancer
| journal = [[British journal of cancer]]
| volume = 63
| issue = 5
| pages = 814–818
| year = 1991
| month = May
| pmid = 1645564
}}</ref>
===Mature teratoma===
===Mature teratoma===
* Patients of all age groups may develop mature teratoma. However, they tend to present between 20 to 30 years of age at a greater extent.<ref name="Yayla AbideBostancı Ergen2018">{{cite journal|last1=Yayla Abide|first1=Çiğdem|last2=Bostancı Ergen|first2=Evrim|title=Retrospective analysis of mature cystic teratomas in a single center and review of the literature|journal=Journal of Turkish Society of Obstetric and Gynecology|volume=15|issue=2|year=2018|pages=95–98|issn=1307699X|doi=10.4274/tjod.86244}}</ref>
* Patients of all age groups may develop mature teratoma. However, they tend to present between 20 to 30 years of age at a greater extent.<ref name="Yayla AbideBostancı Ergen2018">{{cite journal|last1=Yayla Abide|first1=Çiğdem|last2=Bostancı Ergen|first2=Evrim|title=Retrospective analysis of mature cystic teratomas in a single center and review of the literature|journal=Journal of Turkish Society of Obstetric and Gynecology|volume=15|issue=2|year=2018|pages=95–98|issn=1307699X|doi=10.4274/tjod.86244}}</ref>

Revision as of 19:03, 15 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Epidemiology and Demographics

Incidence

  • The malignant ovarian germ cell tumors incidence increses from 5 years of age, although it may be presnt during infancy, and this increase continues to peak between the age of 15 to 19 years which is approximately 1.2 per 100,000 women.[1][2][3]

Mature teratoma

Dysgerminoma

Yolk sac tumor

Embryonal carcinoma

Choriocarcinom

Prevalence

Mature teratoma

Dysgerminoma

Mixed germ cell tumor

Embryonal carcinoma

Endodermal sinus tumor

Non-gestational choriocarcinoma

Age

  • Although The malignant germ cell tumors may be present during the infancy, the has been reported between the age of 15 and 19 years where dysgerminoma is the most common type observed.
  • In those who are aged 9 years old or younger, the incidence has been reported to be 0.1 per 100,000 girls.[13]
  • In those between the age of 10 to 19 years old, the incidence has been reported to be 1.1 per 100,000 girls.
  • Another peak incidence of these tumors has been reported among those aged 65 years old or older where teratoma is the most common type observed.[14]

Mature teratoma

  • Patients of all age groups may develop mature teratoma. However, they tend to present between 20 to 30 years of age at a greater extent.[15]
  • The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.

Immature teratoma

  • Immature teratoma tends to affect younger patient than mature teratomas (usually the first 2 decades of life).[16]

Dysgerminoma

  • Dysgerminoma commonly affects individuals younger than 30 years of age in 85% of cases.[9]
  • The median age at the time of diagnosis is approximately 19 to 23 years, although it may happen at any age.[17]
  • The tumor is uncommon prepubertal or postmenopausal.
  • [Chronic disease name] is usually first diagnosed among [age group].
  • [Acute disease name] commonly affects [age group].

Yolk sac tumor

  • They are most common in women in the second and third decades of life and rarely happens after the age 40.[18]

Embryonal carcinoma

  • They affect primarily children and young adults.[19]

Choriocarcinoma

Race

Gender

Region

Developed Countries

Developing Countries

References

  1. Quirk, Jeffrey T.; Natarajan, Nachimuthu; Mettlin, Curtis J. (2005). "Age-specific ovarian cancer incidence rate patterns in the United States". Gynecologic Oncology. 99 (1): 248–250. doi:10.1016/j.ygyno.2005.06.052. ISSN 0090-8258.
  2. I. dos Santos Silva & A. J. Swerdlow (1991). "Ovarian germ cell malignancies in England: epidemiological parallels with testicular cancer". British journal of cancer. 63 (5): 814–818. PMID 1645564. Unknown parameter |month= ignored (help)
  3. Henrik Moller & Helen Evans (2003). "Epidemiology of gonadal germ cell cancer in males and females". APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 111 (1): 43–46. PMID 12752232. Unknown parameter |month= ignored (help)
  4. Pectasides, D.; Pectasides, E.; Kassanos, D. (2008). "Germ cell tumors of the ovary". Cancer Treatment Reviews. 34 (5): 427–441. doi:10.1016/j.ctrv.2008.02.002. ISSN 0305-7372.
  5. Westhoff C, Pike M, Vessey M (July 1988). "Benign ovarian teratomas: a population-based case-control study". Br. J. Cancer. 58 (1): 93–8. PMC 2246492. PMID 3166898.
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Smith, Harriet O.; Berwick, Marianne; Verschraegen, Claire F.; Wiggins, Charles; Lansing, Letitia; Muller, Carolyn Y.; Qualls, Clifford R. (2006). "Incidence and Survival Rates for Female Malignant Germ Cell Tumors". Obstetrics & Gynecology. 107 (5): 1075–1085. doi:10.1097/01.AOG.0000216004.22588.ce. ISSN 0029-7844.
  7. Shaaban, Akram M.; Rezvani, Maryam; Elsayes, Khaled M.; Baskin, Henry; Mourad, Amr; Foster, Bryan R.; Jarboe, Elke A.; Menias, Christine O. (2014). "Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features". RadioGraphics. 34 (3): 777–801. doi:10.1148/rg.343130067. ISSN 0271-5333.
  8. 8.0 8.1 Ulbright, Thomas M (2005). "Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues". Modern Pathology. 18: S61–S79. doi:10.1038/modpathol.3800310. ISSN 0893-3952.
  9. 9.0 9.1 Vicus, Danielle; Beiner, Mario E.; Klachook, Shany; Le, Lisa W.; Laframboise, Stephane; Mackay, Helen (2010). "Pure dysgerminoma of the ovary 35 years on: A single institutional experience". Gynecologic Oncology. 117 (1): 23–26. doi:10.1016/j.ygyno.2009.12.024. ISSN 0090-8258.
  10. 10.0 10.1 Tewari, K (2000). "Malignant germ cell tumors of the ovary". Obstetrics & Gynecology. 95 (1): 128–133. doi:10.1016/S0029-7844(99)00470-6. ISSN 0029-7844.
  11. Cheng, Liang; Zhang, Shaobo; Talerman, Aleksander; Roth, Lawrence M. (2010). "Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma". Human Pathology. 41 (5): 716–723. doi:10.1016/j.humpath.2009.10.016. ISSN 0046-8177.
  12. Jiao, Lan-zhou; Xiang, Yang; Feng, Feng-zhi; Wan, Xi-run; Zhao, Jun; Cui, Quan-cai; Yang, Xiu-yu (2010). "Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma". International Journal of Gynecological Cancer. 20 (2): 299–302. doi:10.1111/IGC.0b013e3181cc2526. ISSN 1048-891X.
  13. Brookfield, Kathleen F.; Cheung, Michael C.; Koniaris, Leonidas G.; Sola, Juan E.; Fischer, Anne C. (2009). "A Population-Based Analysis of 1037 Malignant Ovarian Tumors in the Pediatric Population". Journal of Surgical Research. 156 (1): 45–49. doi:10.1016/j.jss.2009.03.069. ISSN 0022-4804.
  14. I. dos Santos Silva & A. J. Swerdlow (1991). "Ovarian germ cell malignancies in England: epidemiological parallels with testicular cancer". British journal of cancer. 63 (5): 814–818. PMID 1645564. Unknown parameter |month= ignored (help)
  15. Yayla Abide, Çiğdem; Bostancı Ergen, Evrim (2018). "Retrospective analysis of mature cystic teratomas in a single center and review of the literature". Journal of Turkish Society of Obstetric and Gynecology. 15 (2): 95–98. doi:10.4274/tjod.86244. ISSN 1307-699X.
  16. Outwater, Eric K.; Siegelman, Evan S.; Hunt, Jennifer L. (2001). "Ovarian Teratomas: Tumor Types and Imaging Characteristics". RadioGraphics. 21 (2): 475–490. doi:10.1148/radiographics.21.2.g01mr09475. ISSN 0271-5333.
  17. A L Husaini H, Soudy H, El Din Darwish A, Ahmed M, Eltigani A, A L Mubarak M, Sabaa AA, Edesa W, A L-Tweigeri T, Al-Badawi IA (December 2012). "Pure dysgerminoma of the ovary: a single institutional experience of 65 patients". Med. Oncol. 29 (4): 2944–8. doi:10.1007/s12032-012-0194-z. PMID 22407668. Vancouver style error: missing comma (help)
  18. Kurman RJ, Norris HJ (December 1976). "Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases". Cancer. 38 (6): 2404–19. PMID 63318.
  19. 19.0 19.1 19.2 Chen, Vivien W.; Ruiz, Bernardo; Killeen, Jeffrey L.; Cot�, Timothy R.; Wu, Xiao Cheng; Correa, Catherine N.; Howe, Holly L. (2003). "Pathology and classification of ovarian tumors". Cancer. 97 (S10): 2631–2642. doi:10.1002/cncr.11345. ISSN 0008-543X. replacement character in |last4= at position 4 (help)

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