Glucose-6-phosphate dehydrogenase deficiency historical perspective: Difference between revisions

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==Overview==
==Overview==
G6PD deficiency was first discovered more than 50 years ago. Prisoner volunteers were given primaquine and some of them developed hemolytic anemia


==Historical Perspective==
==Historical Perspective==


===Discovery===
===Discovery===
*[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].<ref name="pmid25943156">{{cite journal |vauthors=Baird K |title=Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria |journal=Pathog Glob Health |volume=109 |issue=3 |pages=93–106 |date=May 2015 |pmid=25943156 |pmc=4455359 |doi=10.1179/2047773215Y.0000000016 |url=}}</ref>
*G6PD deficiency was first discovered more than 50 years ago.<ref name="pmid18156501">{{cite journal |vauthors=Beutler E |title=Glucose-6-phosphate dehydrogenase deficiency: a historical perspective |journal=Blood |volume=111 |issue=1 |pages=16–24 |date=January 2008 |pmid=18156501 |doi=10.1182/blood-2007-04-077412 |url=}}</ref>


*The association between primaquine and discovery of G6PD deficiency was made during  a study at Illinois State Penitentiary.  Prisoner volunteers were given primaquine and some of them developed hemolytic anemia.
*The association between [[primaquine]] and discovery of G6PD deficiency was made during  a study at Illinois State Penitentiary.  Prisoner volunteers were given [[primaquine]] and some of them developed [[hemolytic anemia]].<ref name="pmid25943156">{{cite journal |vauthors=Baird K |title=Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria |journal=Pathog Glob Health |volume=109 |issue=3 |pages=93–106 |date=May 2015 |pmid=25943156 |pmc=4455359 |doi=10.1179/2047773215Y.0000000016 |url=}}</ref>
*Numerous soldiers developed hemolytic anemia after taking primaquine to prevent relapsing infection by plasmodium vivax during Korean War.  
*Numerous soldiers developed hemolytic anemia after taking primaquine to prevent relapsing infection by plasmodium vivax during Korean War. Most of them are from North African and Mediterranean.
*In spite of these results, the US military administered the drug widely during the Korean War to prevent the relapsing infection caused by Plasmodium vivax hypnozoites. Numerous cases of hemolytic anemia were observed in US soldiers of North African and Mediterranean descent.
*
*
*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].


==Outbreaks==
==Outbreaks==

Revision as of 13:31, 27 August 2018


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

G6PD deficiency was first discovered more than 50 years ago. Prisoner volunteers were given primaquine and some of them developed hemolytic anemia

Historical Perspective

Discovery

  • G6PD deficiency was first discovered more than 50 years ago.[1]
  • The association between primaquine and discovery of G6PD deficiency was made during a study at Illinois State Penitentiary. Prisoner volunteers were given primaquine and some of them developed hemolytic anemia.[2]
  • Numerous soldiers developed hemolytic anemia after taking primaquine to prevent relapsing infection by plasmodium vivax during Korean War. Most of them are from North African and Mediterranean.

Outbreaks

There have been several outbreaks of [disease name], which are summarized below:

Landmark Events in the Development of Treatment Strategies

In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

Impact on Cultural History

Famous Cases

The following are a few famous cases of disease name:

References

  1. Beutler E (January 2008). "Glucose-6-phosphate dehydrogenase deficiency: a historical perspective". Blood. 111 (1): 16–24. doi:10.1182/blood-2007-04-077412. PMID 18156501.
  2. Baird K (May 2015). "Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria". Pathog Glob Health. 109 (3): 93–106. doi:10.1179/2047773215Y.0000000016. PMC 4455359. PMID 25943156.

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