Peptic ulcer natural history: Difference between revisions

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==Overview==
==Overview==
''[[Helicobacter pylori]] infection is a'' common cause of [[peptic ulcer disease]] which is acquired usually during childhood but presents in second to fifth decade of life. Patient presents with episodic [[epigastric pain]], [[indigestion]], [[bloating]],[[hematemesis]] and [[melena]]. If not treated, patients can develop [[complications]] like [[bleeding]], [[perforation]], [[obstruction]] or [[stricture]]. Chronic infection of [[helicobacter pylori]] leads to [[gastric cancer]], [[MALT lymphoma|MALT lymphoma,]] [[Iron deficiency anemia|iron deficiency anemia,]] [[Idiopathic thrombocytopenic purpura]][[Peptic ulcers|. Peptic ulcers]] tend to recur if left untreated. Prognosis is good if the eradication therapy of [[Helicobacter pylori]] is taken.The recurrence rate of patients with [[peptic ulcer disease]] is less than 20%.
''[[Helicobacter pylori]] infection is a'' common cause of [[peptic ulcer disease]] which is acquired usually during childhood but presents in second to fifth decade of life. Patient presents with episodic [[epigastric pain]], [[indigestion]], [[bloating]],[[hematemesis]] and [[melena]]. If not treated, patients can develop [[complications]] like [[bleeding]], [[perforation]], [[obstruction]] or [[stricture]]. Chronic infection of [[helicobacter pylori]] leads to [[gastric cancer]], [[MALT lymphoma|MALT lymphoma,]] [[Iron deficiency anemia|iron deficiency anemia,]] [[Idiopathic thrombocytopenic purpura]][[Peptic ulcers|. Peptic ulcers]] tend to recur if left untreated. Prognosis is good if the eradication therapy of [[Helicobacter pylori]] is taken.The recurrence rate of patients with [[peptic ulcer disease]] is less than 20%.
==Natural History==
==Natural History==
*The infection of ''[[Helicobacter pylori]]'' , common cause of [[peptic ulcer disease]] is acquired usually during the childhood, mainly in those who have low socioeconomic status, increased number of siblings and similar [[infection]] in the mother.<ref name="pmid11045838">{{cite journal |vauthors=Opekun AR, Gilger MA, Denyes SM, Nirken MH, Philip SP, Osato MS, Malaty HM, Hicks J, Graham DY |title=Helicobacter pylori infection in children of Texas |journal=J. Pediatr. Gastroenterol. Nutr. |volume=31 |issue=4 |pages=405–10 |year=2000 |pmid=11045838 |doi= |url=}}</ref><ref name="pmid11063492">{{cite journal |vauthors=Parkinson AJ, Gold BD, Bulkow L, Wainwright RB, Swaminathan B, Khanna B, Petersen KM, Fitzgerald MA |title=High prevalence of Helicobacter pylori in the Alaska native population and association with low serum ferritin levels in young adults |journal=Clin. Diagn. Lab. Immunol. |volume=7 |issue=6 |pages=885–8 |year=2000 |pmid=11063492 |pmc=95979 |doi= |url=}}</ref><ref name="pmid11918912">{{cite journal |vauthors=Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS |title=Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood |journal=Lancet |volume=359 |issue=9310 |pages=931–5 |year=2002 |pmid=11918912 |doi=10.1016/S0140-6736(02)08025-X |url=}}</ref>   
*The infection of ''[[Helicobacter pylori]]'' , common cause of [[peptic ulcer disease]] is acquired usually during the childhood, mainly in those who have low socioeconomic status, increased number of siblings and similar [[infection]] in the mother.<ref name="pmid11045838">{{cite journal |vauthors=Opekun AR, Gilger MA, Denyes SM, Nirken MH, Philip SP, Osato MS, Malaty HM, Hicks J, Graham DY |title=Helicobacter pylori infection in children of Texas |journal=J. Pediatr. Gastroenterol. Nutr. |volume=31 |issue=4 |pages=405–10 |year=2000 |pmid=11045838 |doi= |url=}}</ref><ref name="pmid11063492">{{cite journal |vauthors=Parkinson AJ, Gold BD, Bulkow L, Wainwright RB, Swaminathan B, Khanna B, Petersen KM, Fitzgerald MA |title=High prevalence of Helicobacter pylori in the Alaska native population and association with low serum ferritin levels in young adults |journal=Clin. Diagn. Lab. Immunol. |volume=7 |issue=6 |pages=885–8 |year=2000 |pmid=11063492 |pmc=95979 |doi= |url=}}</ref><ref name="pmid11918912">{{cite journal |vauthors=Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS |title=Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood |journal=Lancet |volume=359 |issue=9310 |pages=931–5 |year=2002 |pmid=11918912 |doi=10.1016/S0140-6736(02)08025-X |url=}}</ref>   

Revision as of 00:34, 2 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Helicobacter pylori infection is a common cause of peptic ulcer disease which is acquired usually during childhood but presents in second to fifth decade of life. Patient presents with episodic epigastric pain, indigestion, bloating,hematemesis and melena. If not treated, patients can develop complications like bleeding, perforation, obstruction or stricture. Chronic infection of helicobacter pylori leads to gastric cancer, MALT lymphoma, iron deficiency anemia, Idiopathic thrombocytopenic purpura. Peptic ulcers tend to recur if left untreated. Prognosis is good if the eradication therapy of Helicobacter pylori is taken.The recurrence rate of patients with peptic ulcer disease is less than 20%.

Natural History

Complications

Acute complications :

Chronic complications:

Chronic Helicobacter pylori infection leads to:

Prognosis

References

  1. Opekun AR, Gilger MA, Denyes SM, Nirken MH, Philip SP, Osato MS, Malaty HM, Hicks J, Graham DY (2000). "Helicobacter pylori infection in children of Texas". J. Pediatr. Gastroenterol. Nutr. 31 (4): 405–10. PMID 11045838.
  2. Parkinson AJ, Gold BD, Bulkow L, Wainwright RB, Swaminathan B, Khanna B, Petersen KM, Fitzgerald MA (2000). "High prevalence of Helicobacter pylori in the Alaska native population and association with low serum ferritin levels in young adults". Clin. Diagn. Lab. Immunol. 7 (6): 885–8. PMC 95979. PMID 11063492.
  3. Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS (2002). "Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood". Lancet. 359 (9310): 931–5. doi:10.1016/S0140-6736(02)08025-X. PMID 11918912.
  4. Kusters JG, van Vliet AH, Kuipers EJ (2006). "Pathogenesis of Helicobacter pylori infection". Clin. Microbiol. Rev. 19 (3): 449–90. doi:10.1128/CMR.00054-05. PMC 1539101. PMID 16847081.
  5. Milosavljevic T, Kostić-Milosavljević M, Jovanović I, Krstić M (2011). "Complications of peptic ulcer disease". Dig Dis. 29 (5): 491–3. doi:10.1159/000331517. PMID 22095016.
  6. Cullen DJ, Hawkey GM, Greenwood DC; et al. (1997). "Peptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs". Gut. 41 (4): 459–62. PMID 9391242.
  7. "Peptic Ulcer: Peptic Disorders: Merck Manual Home Edition". Retrieved 2007-10-10.
  8. "Peptic Ulcer: Peptic Disorders: Merck Manual Home Edition". Retrieved 2007-10-10.


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