SUZ12: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Polycomb protein SUZ12''' is a [[protein]] that in humans is encoded by the ''SUZ12'' [[gene]].<ref name="pmid8590280">{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199-210 | date = August 1995 | pmid = 8590280 | pmc =  | doi = 10.1093/dnares/2.4.167 }}</ref><ref name="pmid11371647">{{cite journal | vauthors = Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J | title = Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 11 | pages = 6348–53 | date = May 2001 | pmid = 11371647 | pmc = 33471 | doi = 10.1073/pnas.101132598 }}</ref><ref name="pmid18784248">{{cite journal | vauthors = Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB | title = Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development | journal = Reproduction | volume = 136 | issue = 6 | pages = 777–85 | date = December 2008 | pmid = 18784248 | pmc =  | doi = 10.1530/REP-08-0045 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Suppressor of zeste 12 homolog (Drosophila)
| HGNCid = 17101
| Symbol = SUZ12
| AltSymbols =; CHET9; JJAZ1; KIAA0160
| OMIM = 606245
| ECnumber = 
| Homologene = 32256
| MGIid = 1261758
| GeneAtlas_image1 = PBB_GE_SUZ12_212287_at_tn.png
| GeneAtlas_image2 = PBB_GE_SUZ12_213971_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0042054 |text = histone methyltransferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0001739 |text = sex chromatin}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0035098 |text = ESC/E(Z) complex}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} {{GNF_GO|id=GO:0016571 |text = histone methylation}} {{GNF_GO|id=GO:0016574 |text = histone ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23512
    | Hs_Ensembl = ENSG00000178691
    | Hs_RefseqProtein = NP_056170
    | Hs_RefseqmRNA = NM_015355
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 27288185
    | Hs_GenLoc_end = 27352162
    | Hs_Uniprot = Q15022
    | Mm_EntrezGene = 52615
    | Mm_Ensembl = ENSMUSG00000017548
    | Mm_RefseqmRNA = NM_199196
    | Mm_RefseqProtein = NP_954666
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 79809301
    | Mm_GenLoc_end = 79850318
    | Mm_Uniprot = Q3URR6
  }}
}}
'''Suppressor of zeste 12 homolog (Drosophila)''', also known as '''SUZ12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This zinc finger gene has been identified at the breakpoints of a recurrent [[chromosomal translocation]] reported in endometrial stromal sarcoma. [[Genetic recombination|Recombination]] of these breakpoints results in the fusion of this gene and [[JAZF1]]. The protein encoded by this gene contains a zinc finger domain in the [[C terminus]] of the coding region. The specific function of this gene has not yet been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512| accessdate = }}</ref>
}}


==References==
SUZ12, as part of Polycomb Repressive Complex 2 ([[PRC2]]), may be involved with chromatin silencing in conjunction with [[HOTAIR]] ncRNA, using its [[zinc-finger]] domain to bind the RNA molecule.<ref name="Rinn">{{cite journal | vauthors = Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY | title = Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs | journal = Cell | volume = 129 | issue = 7 | pages = 1311–23 | date = June 2007 | pmid = 17604720 | pmc = 2084369 | doi = 10.1016/j.cell.2007.05.022 }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Birve A, Sengupta AK, Beuchle D, Larsson J, Kennison JA, Müller J | title = Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants | journal = Development | volume = 128 | issue = 17 | pages = 3371–9 | date = September 2001 | pmid = 11546753 | doi =  }}
| citations =
* {{cite journal | vauthors = Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ | title = Use of chromatin immunoprecipitation to clone novel E2F target promoters | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 6820–32 | date = October 2001 | pmid = 11564866 | pmc = 99859 | doi = 10.1128/MCB.21.20.6820-6832.2001 }}
*{{cite journal  | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
* {{cite journal | vauthors = Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y | title = Role of histone H3 lysine 27 methylation in Polycomb-group silencing | journal = Science | volume = 298 | issue = 5595 | pages = 1039–43 | date = November 2002 | pmid = 12351676 | doi = 10.1126/science.1076997 }}
*{{cite journal | author=Koontz JI, Soreng AL, Nucci M, ''et al.'' |title=Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6348-53 |year= 2001 |pmid= 11371647 |doi= 10.1073/pnas.101132598 }}
* {{cite journal | vauthors = Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein | journal = Genes & Development | volume = 16 | issue = 22 | pages = 2893–905 | date = November 2002 | pmid = 12435631 | pmc = 187479 | doi = 10.1101/gad.1035902 }}
*{{cite journal  | author=Birve A, Sengupta AK, Beuchle D, ''et al.'' |title=Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. |journal=Development |volume=128 |issue= 17 |pages= 3371-9 |year= 2001 |pmid= 11546753 |doi=  }}
* {{cite journal | vauthors = Petek E, Jenne DE, Smolle J, Binder B, Lasinger W, Windpassinger C, Wagner K, Kroisel PM, Kehrer-Sawatzki H | title = Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations | journal = Journal of Medical Genetics | volume = 40 | issue = 7 | pages = 520–5 | date = July 2003 | pmid = 12843325 | pmc = 1735521 | doi = 10.1136/jmg.40.7.520 }}
*{{cite journal | author=Weinmann AS, Bartley SM, Zhang T, ''et al.'' |title=Use of chromatin immunoprecipitation to clone novel E2F target promoters. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6820-32 |year= 2001 |pmid= 11564866 |doi= 10.1128/MCB.21.20.6820-6832.2001 }}
* {{cite journal | vauthors = Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y | title = mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 475–87 | date = August 2003 | pmid = 14536086 | doi = 10.1016/j.molcel.2003.08.007 }}
*{{cite journal | author=Cao R, Wang L, Wang H, ''et al.'' |title=Role of histone H3 lysine 27 methylation in Polycomb-group silencing. |journal=Science |volume=298 |issue= 5595 |pages= 1039-43 |year= 2002 |pmid= 12351676 |doi= 10.1126/science.1076997 }}
* {{cite journal | vauthors = Huang HY, Ladanyi M, Soslow RA | title = Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity | journal = The American Journal of Surgical Pathology | volume = 28 | issue = 2 | pages = 224–32 | date = February 2004 | pmid = 15043312 | doi = 10.1097/00000478-200402000-00010 }}
*{{cite journal | author=Kuzmichev A, Nishioka K, Erdjument-Bromage H, ''et al.'' |title=Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. |journal=Genes Dev. |volume=16 |issue= 22 |pages= 2893-905 |year= 2002 |pmid= 12435631 |doi= 10.1101/gad.1035902 }}
* {{cite journal | vauthors = Cao R, Zhang Y | title = SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex | journal = Molecular Cell | volume = 15 | issue = 1 | pages = 57–67 | date = July 2004 | pmid = 15225548 | doi = 10.1016/j.molcel.2004.06.020 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kehrer-Sawatzki H, Kluwe L, Sandig C, Kohn M, Wimmer K, Krammer U, Peyrl A, Jenne DE, Hansmann I, Mautner VF | title = High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene | journal = American Journal of Human Genetics | volume = 75 | issue = 3 | pages = 410–23 | date = September 2004 | pmid = 15257518 | pmc = 1182020 | doi = 10.1086/423624 }}
*{{cite journal  | author=Petek E, Jenne DE, Smolle J, ''et al.'' |title=Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= 520-5 |year= 2003 |pmid= 12843325 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Wang H, An W, Cao R, ''et al.'' |title=mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 475-87 |year= 2003 |pmid= 14536086 |doi= }}
* {{cite journal | vauthors = Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K | title = Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity | journal = The EMBO Journal | volume = 23 | issue = 20 | pages = 4061–71 | date = October 2004 | pmid = 15385962 | pmc = 524339 | doi = 10.1038/sj.emboj.7600402 }}
*{{cite journal | author=Huang HY, Ladanyi M, Soslow RA |title=Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. |journal=Am. J. Surg. Pathol. |volume=28 |issue= 2 |pages= 224-32 |year= 2004 |pmid= 15043312 |doi= }}
* {{cite journal | vauthors = Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC | title = Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 | journal = Science | volume = 310 | issue = 5746 | pages = 306–10 | date = October 2005 | pmid = 16224021 | doi = 10.1126/science.1118947 }}
*{{cite journal | author=Cao R, Zhang Y |title=SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. |journal=Mol. Cell |volume=15 |issue= 1 |pages= 57-67 |year= 2004 |pmid= 15225548 |doi= 10.1016/j.molcel.2004.06.020 }}
* {{cite journal | vauthors = Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA | title = Control of developmental regulators by Polycomb in human embryonic stem cells | journal = Cell | volume = 125 | issue = 2 | pages = 301–13 | date = April 2006 | pmid = 16630818 | doi = 10.1016/j.cell.2006.02.043 }}
*{{cite journal | author=Kehrer-Sawatzki H, Kluwe L, Sandig C, ''et al.'' |title=High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene. |journal=Am. J. Hum. Genet. |volume=75 |issue= 3 |pages= 410-23 |year= 2004 |pmid= 15257518 |doi= 10.1086/423624 }}
* {{cite journal | vauthors = Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K | title = Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro | journal = Biochemical and Biophysical Research Communications | volume = 345 | issue = 3 | pages = 1051–8 | date = July 2006 | pmid = 16712789 | doi = 10.1016/j.bbrc.2006.05.014 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Pasini D, Bracken AP, Jensen MR, ''et al.'' |title=Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. |journal=EMBO J. |volume=23 |issue= 20 |pages= 4061-71 |year= 2004 |pmid= 15385962 |doi= 10.1038/sj.emboj.7600402 }}
* {{cite journal | vauthors = Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J | title = Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms | journal = The American Journal of Surgical Pathology | volume = 31 | issue = 1 | pages = 65–70 | date = January 2007 | pmid = 17197920 | doi = 10.1097/01.pas.0000213327.86992.d1 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Cha TL, Zhou BP, Xia W, ''et al.'' |title=Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. |journal=Science |volume=310 |issue= 5746 |pages= 306-10 |year= 2005 |pmid= 16224021 |doi= 10.1126/science.1118947 }}
*{{cite journal | author=Lee TI, Jenner RG, Boyer LA, ''et al.'' |title=Control of developmental regulators by Polycomb in human embryonic stem cells. |journal=Cell |volume=125 |issue= 2 |pages= 301-13 |year= 2006 |pmid= 16630818 |doi= 10.1016/j.cell.2006.02.043 }}
*{{cite journal | author=Furuno K, Masatsugu T, Sonoda M, ''et al.'' |title=Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 3 |pages= 1051-8 |year= 2006 |pmid= 16712789 |doi= 10.1016/j.bbrc.2006.05.014 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Nucci MR, Harburger D, Koontz J, ''et al.'' |title=Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. |journal=Am. J. Surg. Pathol. |volume=31 |issue= 1 |pages= 65-70 |year= 2007 |pmid= 17197920 |doi= 10.1097/01.pas.0000213327.86992.d1 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{FactorBook|SUZ12}}

Revision as of 07:19, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.[1][2][3][4]

Function

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.[4]

SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.[5]

References

  1. ↑ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  2. ↑ Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J (May 2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6348–53. doi:10.1073/pnas.101132598. PMC 33471. PMID 11371647.
  3. ↑ Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB (December 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction. 136 (6): 777–85. doi:10.1530/REP-08-0045. PMID 18784248.
  4. ↑ 4.0 4.1 "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)".
  5. ↑ Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY (June 2007). "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs". Cell. 129 (7): 1311–23. doi:10.1016/j.cell.2007.05.022. PMC 2084369. PMID 17604720.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=SUZ12&oldid=1417822"