GFPT1: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1''' is an [[enzyme]] that in humans is encoded by the ''GFPT1'' [[gene]].<ref name="pmid1460020">{{cite journal |vauthors=McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ | title = Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase | journal = J Biol Chem | volume = 267 | issue = 35 | pages = 25208–12 |date=Jan 1993 | pmid = 1460020 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2673| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Glutamine-fructose-6-phosphate transaminase 1
| HGNCid = 4241
| Symbol = GFPT1
| AltSymbols =; GFA; GFAT; GFAT1; GFAT1m; GFPT
| OMIM = 138292
| ECnumber = 
| Homologene = 68220
| MGIid = 95698
| GeneAtlas_image1 = PBB_GE_GFPT1_202722_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GFPT1_202721_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004360 |text = glutamine-fructose-6-phosphate transaminase (isomerizing) activity}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006002 |text = fructose 6-phosphate metabolic process}} {{GNF_GO|id=GO:0006112 |text = energy reserve metabolic process}} {{GNF_GO|id=GO:0006541 |text = glutamine metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0016051 |text = carbohydrate biosynthetic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2673
    | Hs_Ensembl = ENSG00000198380
    | Hs_RefseqProtein = NP_002047
    | Hs_RefseqmRNA = NM_002056
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 69405907
    | Hs_GenLoc_end = 69467886
    | Hs_Uniprot = Q06210
    | Mm_EntrezGene = 14583
    | Mm_Ensembl = ENSMUSG00000029992
    | Mm_RefseqmRNA = NM_013528
    | Mm_RefseqProtein = NP_038556
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 87008525
    | Mm_GenLoc_end = 87053873
    | Mm_Uniprot = P47856
  }}
}}
'''Glutamine-fructose-6-phosphate transaminase 1''', also known as '''GFPT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2673| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway.  GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.<ref name="entrez">{{cite web | title = Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2673| accessdate = }}</ref>
| summary_text = [[Glutamine]]-[[fructose]]-6-[[phosphate]] transaminase 1 is the first and rate-limiting enzyme of the [[hexosamine]] pathway.  GFAT controls the flux of [[glucose]] into the hexosamine pathway and [[catalyzes]] the formation of [[glucosamine]] 6-phosphate.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schleicher ED, Weigert C |title=Role of the hexosamine biosynthetic pathway in diabetic nephropathy. |journal=Kidney Int. Suppl. |volume=77 |issue=  |pages= S13-8 |year= 2001 |pmid= 10997685 |doi=  }}
*{{cite journal  |vauthors=Schleicher ED, Weigert C |title=Role of the hexosamine biosynthetic pathway in diabetic nephropathy |journal=Kidney Int. Suppl. |volume=77 |issue=  |pages= S13–8 |year= 2001 |pmid= 10997685 |doi=  }}
*{{cite journal  | author=McKnight GL, Mudri SL, Mathewes SL, ''et al.'' |title=Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. |journal=J. Biol. Chem. |volume=267 |issue= 35 |pages= 25208-12 |year= 1993 |pmid= 1460020 |doi=  }}
*{{cite journal  |vauthors=Traxinger RR, Marshall S |title=Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10148–54 |year= 1991 |pmid= 2037571 |doi=  }}
*{{cite journal  | author=Traxinger RR, Marshall S |title=Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10148-54 |year= 1991 |pmid= 2037571 |doi= }}
*{{cite journal  |vauthors=Whitmore TE, Mudri SL, McKnight GL |title=Physical mapping of the human glutamine:fructose-6-phosphate amidotransferase gene (GFPT) to chromosome 2p13 |journal=Genomics |volume=26 |issue= 2 |pages= 422–3 |year= 1995 |pmid= 7601477 |doi=10.1016/0888-7543(95)80235-E  }}
*{{cite journal  | author=Whitmore TE, Mudri SL, McKnight GL |title=Physical mapping of the human glutamine:fructose-6-phosphate amidotransferase gene (GFPT) to chromosome 2p13. |journal=Genomics |volume=26 |issue= 2 |pages= 422-3 |year= 1995 |pmid= 7601477 |doi=  }}
*{{cite journal  | author=Zhou J |title=Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13 |journal=Hum. Genet. |volume=96 |issue= 1 |pages= 99–101 |year= 1995 |pmid= 7607664 |doi=10.1007/BF00214194 |name-list-format=vanc| author2=Neidigh JL | author3=Espinosa R | display-authors=3  | last4=Lebeau  | first4=Michelle M. | last5=McClain  | first5=Donald A. }}
*{{cite journal  | author=Zhou J, Neidigh JL, Espinosa R, ''et al.'' |title=Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13. |journal=Hum. Genet. |volume=96 |issue= 1 |pages= 99-101 |year= 1995 |pmid= 7607664 |doi=  }}
*{{cite journal  |vauthors=Sayeski PP, Paterson AJ, Kudlow JE |title=The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence |journal=Gene |volume=140 |issue= 2 |pages= 289–90 |year= 1994 |pmid= 8144040 |doi=10.1016/0378-1119(94)90560-6  }}
*{{cite journal  | author=Sayeski PP, Paterson AJ, Kudlow JE |title=The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence. |journal=Gene |volume=140 |issue= 2 |pages= 289-90 |year= 1994 |pmid= 8144040 |doi= }}
*{{cite journal  | author=Nerlich AG |title=Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes |journal=Diabetes |volume=47 |issue= 2 |pages= 170–8 |year= 1998 |pmid= 9519709 |doi=10.2337/diabetes.47.2.170 |name-list-format=vanc| author2=Sauer U  | author3=Kolm-Litty V  | display-authors=3  | last4=Wagner  | first4=E.  | last5=Koch  | first5=M.  | last6=Schleicher  | first6=E. D. }}
*{{cite journal  | author=Nerlich AG, Sauer U, Kolm-Litty V, ''et al.'' |title=Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes. |journal=Diabetes |volume=47 |issue= 2 |pages= 170-8 |year= 1998 |pmid= 9519709 |doi= }}
*{{cite journal  | author=Oki T |title=cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse |journal=Genomics |volume=57 |issue= 2 |pages= 227–34 |year= 1999 |pmid= 10198162 |doi= 10.1006/geno.1999.5785  |name-list-format=vanc| author2=Yamazaki K  | author3=Kuromitsu J  | display-authors=3  | last4=Okada  | first4=M  | last5=Tanaka  | first5=I }}
*{{cite journal | author=Oki T, Yamazaki K, Kuromitsu J, ''et al.'' |title=cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse. |journal=Genomics |volume=57 |issue= 2 |pages= 227-34 |year= 1999 |pmid= 10198162 |doi= 10.1006/geno.1999.5785 }}
*{{cite journal  | author=Chang Q |title=Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 21981–7 |year= 2000 |pmid= 10806197 |doi= 10.1074/jbc.M001049200 |name-list-format=vanc| author2=Su K  | author3=Baker JR  | display-authors=3  | last4=Yang  | first4=X  | last5=Paterson  | first5=AJ  | last6=Kudlow  | first6=JE }}
*{{cite journal  | author=Chang Q, Su K, Baker JR, ''et al.'' |title=Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 21981-7 |year= 2000 |pmid= 10806197 |doi= 10.1074/jbc.M001049200 }}
*{{cite journal  | author=Niimi M |title=Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle |journal=J. Hum. Genet. |volume=46 |issue= 10 |pages= 566–71 |year= 2001 |pmid= 11587069 |doi=10.1007/s100380170022  |name-list-format=vanc| author2=Ogawara T | author3=Yamashita T  | display-authors=3  | last4=Yamamoto  | first4=Y.  | last5=Ueyama  | first5=A.  | last6=Kambe  | first6=T.  | last7=Okamoto  | first7=T.  | last8=Ban | first8=T. | last9=Tamanoi  | first9=H.  }}
*{{cite journal  | author=Niimi M, Ogawara T, Yamashita T, ''et al.'' |title=Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle. |journal=J. Hum. Genet. |volume=46 |issue= 10 |pages= 566-71 |year= 2001 |pmid= 11587069 |doi= }}
*{{cite journal |vauthors=DeHaven JE, Robinson KA, Nelson BA, Buse MG |title=A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle |journal=Diabetes |volume=50 |issue= 11 |pages= 2419–24 |year= 2001 |pmid= 11679416 |doi=10.2337/diabetes.50.11.2419  }}
*{{cite journal | author=DeHaven JE, Robinson KA, Nelson BA, Buse MG |title=A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle. |journal=Diabetes |volume=50 |issue= 11 |pages= 2419-24 |year= 2001 |pmid= 11679416 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Weigert C |title=Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells |journal=Diabetologia |volume=46 |issue= 6 |pages= 852–5 |year= 2004 |pmid= 12802498 |doi= 10.1007/s00125-003-1122-8  |name-list-format=vanc| author2=Friess U | author3=Brodbeck K | display-authors=3  | last4=h�Ring  | first4=H. U. | last5=Schleicher  | first5=E. D. }}
*{{cite journal | author=Weigert C, Friess U, Brodbeck K, ''et al.'' |title=Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells. |journal=Diabetologia |volume=46 |issue= 6 |pages= 852-5 |year= 2004 |pmid= 12802498 |doi= 10.1007/s00125-003-1122-8 }}
*{{cite journal  | author=Ng DP |title=Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy |journal=Diabetes |volume=53 |issue= 3 |pages= 865–9 |year= 2004 |pmid= 14988277 |doi=10.2337/diabetes.53.3.865  |name-list-format=vanc| author2=Walker WH  | author3=Chia KS  | display-authors=3  | last4=Choo  | first4=S.  | last5=Warram  | first5=J. H.  | last6=Krolewski  | first6=A. S.  }}
*{{cite journal | author=Ng DP, Walker WH, Chia KS, ''et al.'' |title=Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy. |journal=Diabetes |volume=53 |issue= 3 |pages= 865-9 |year= 2004 |pmid= 14988277 |doi= }}
*{{cite journal  | author=Elbein SC |title=Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy |journal=Mol. Genet. Metab. |volume=82 |issue= 4 |pages= 321–8 |year= 2005 |pmid= 15308130 |doi= 10.1016/j.ymgme.2004.05.004  |name-list-format=vanc| author2=Zheng H  | author3=Jia Y  | display-authors=3  | last4=Chu  | first4=Winston  | last5=Cooper  | first5=Judith J.  | last6=Hale  | first6=Terri  | last7=Zhang  | first7=Zhengxian }}
*{{cite journal  | author=Elbein SC, Zheng H, Jia Y, ''et al.'' |title=Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy. |journal=Mol. Genet. Metab. |volume=82 |issue= 4 |pages= 321-8 |year= 2005 |pmid= 15308130 |doi= 10.1016/j.ymgme.2004.05.004 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Chou KC |title=Molecular therapeutic target for type-2 diabetes |journal=J. Proteome Res. |volume=3 |issue= 6 |pages= 1284–8 |year= 2005 |pmid= 15595739 |doi= 10.1021/pr049849v }}
*{{cite journal  | author=Chou KC |title=Molecular therapeutic target for type-2 diabetes. |journal=J. Proteome Res. |volume=3 |issue= 6 |pages= 1284-8 |year= 2005 |pmid= 15595739 |doi= 10.1021/pr049849v }}
*{{cite journal  | author=Weigert C |title=The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 3 |pages= 1639–43 |year= 2005 |pmid= 15613432 |doi= 10.1210/jc.2004-0058  |name-list-format=vanc| author2=Thamer C  | author3=Brodbeck K  | display-authors=3  | last4=Guirguis  | first4=A  | last5=Machicao  | first5=F  | last6=Machann  | first6=J  | last7=Schick  | first7=F  | last8=Stumvoll  | first8=M  | last9=Fritsche  | first9=A }}
*{{cite journal | author=Weigert C, Thamer C, Brodbeck K, ''et al.'' |title=The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 3 |pages= 1639-43 |year= 2005 |pmid= 15613432 |doi= 10.1210/jc.2004-0058 }}
*{{cite journal  | author=Burt D |title=Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function |journal=Biochim. Biophys. Acta |volume=1740 |issue= 1 |pages= 85–90 |year= 2005 |pmid= 15878746 |doi= 10.1016/j.bbadis.2005.01.007  |name-list-format=vanc| author2=Brodbeck K  | author3=Häring HU  | display-authors=3  | last4=Schleicher  | first4=Erwin D.  | last5=Weigert  | first5=Cora }}
*{{cite journal  | author=Burt D, Brodbeck K, Häring HU, ''et al.'' |title=Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function. |journal=Biochim. Biophys. Acta |volume=1740 |issue= 1 |pages= 85-90 |year= 2005 |pmid= 15878746 |doi= 10.1016/j.bbadis.2005.01.007 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 08:44, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene.[1][2]

Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.[2]

References

  1. ↑ McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ (Jan 1993). "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase". J Biol Chem. 267 (35): 25208–12. PMID 1460020.
  2. ↑ 2.0 2.1 "Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1".

Further reading

  • Schleicher ED, Weigert C (2001). "Role of the hexosamine biosynthetic pathway in diabetic nephropathy". Kidney Int. Suppl. 77: S13–8. PMID 10997685.
  • Traxinger RR, Marshall S (1991). "Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation". J. Biol. Chem. 266 (16): 10148–54. PMID 2037571.
  • Whitmore TE, Mudri SL, McKnight GL (1995). "Physical mapping of the human glutamine:fructose-6-phosphate amidotransferase gene (GFPT) to chromosome 2p13". Genomics. 26 (2): 422–3. doi:10.1016/0888-7543(95)80235-E. PMID 7601477.
  • Zhou J, Neidigh JL, Espinosa R, et al. (1995). "Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13". Hum. Genet. 96 (1): 99–101. doi:10.1007/BF00214194. PMID 7607664.
  • Sayeski PP, Paterson AJ, Kudlow JE (1994). "The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence". Gene. 140 (2): 289–90. doi:10.1016/0378-1119(94)90560-6. PMID 8144040.
  • Nerlich AG, Sauer U, Kolm-Litty V, et al. (1998). "Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes". Diabetes. 47 (2): 170–8. doi:10.2337/diabetes.47.2.170. PMID 9519709.
  • Oki T, Yamazaki K, Kuromitsu J, et al. (1999). "cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse". Genomics. 57 (2): 227–34. doi:10.1006/geno.1999.5785. PMID 10198162.
  • Chang Q, Su K, Baker JR, et al. (2000). "Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity". J. Biol. Chem. 275 (29): 21981–7. doi:10.1074/jbc.M001049200. PMID 10806197.
  • Niimi M, Ogawara T, Yamashita T, et al. (2001). "Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle". J. Hum. Genet. 46 (10): 566–71. doi:10.1007/s100380170022. PMID 11587069.
  • DeHaven JE, Robinson KA, Nelson BA, Buse MG (2001). "A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle". Diabetes. 50 (11): 2419–24. doi:10.2337/diabetes.50.11.2419. PMID 11679416.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Weigert C, Friess U, Brodbeck K, et al. (2004). "Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells". Diabetologia. 46 (6): 852–5. doi:10.1007/s00125-003-1122-8. PMID 12802498. replacement character in |last4= at position 2 (help)
  • Ng DP, Walker WH, Chia KS, et al. (2004). "Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy". Diabetes. 53 (3): 865–9. doi:10.2337/diabetes.53.3.865. PMID 14988277.
  • Elbein SC, Zheng H, Jia Y, et al. (2005). "Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy". Mol. Genet. Metab. 82 (4): 321–8. doi:10.1016/j.ymgme.2004.05.004. PMID 15308130.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chou KC (2005). "Molecular therapeutic target for type-2 diabetes". J. Proteome Res. 3 (6): 1284–8. doi:10.1021/pr049849v. PMID 15595739.
  • Weigert C, Thamer C, Brodbeck K, et al. (2005). "The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects". J. Clin. Endocrinol. Metab. 90 (3): 1639–43. doi:10.1210/jc.2004-0058. PMID 15613432.
  • Burt D, Brodbeck K, Häring HU, et al. (2005). "Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function". Biochim. Biophys. Acta. 1740 (1): 85–90. doi:10.1016/j.bbadis.2005.01.007. PMID 15878746.



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