Aortic stenosis causes: Difference between revisions

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{{Aortic stenosis}}
{{Template:Aortic stenosis}}
{{CMG}}
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'''Associate Editors-In-Chief:''' Claudia P. Hochberg, M.D. [mailto:chochber@bidmc.harvard.edu]; [[User:Abdarabi|Abdul-Rahman Arabi, M.D.]] [mailto:abdarabi@yahoo.com]; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; [[Priyamvada Singh|Priyamvada Singh, MBBS]] [[mailto:psingh@perfuse.org]]
'''Associate Editors-In-Chief:''' Claudia P. Hochberg, M.D. [mailto:chochber@bidmc.harvard.edu]; [[User:Abdarabi|Abdul-Rahman Arabi, M.D.]] [mailto:abdarabi@yahoo.com]; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]
 
'''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [[mailto:kfeeney@perfuse.org]]


==Overview==
==Overview==
Aortic stenosis can be categorized under two methods of causation: '''acquired''' and '''congenital'''. Research regarding the influence of preventative therapies on causation is mixed. More research is needed specifically looking at cholesterol lowering interventions and their role on disease onset.
Aortic stenosis can be categorized under two methods of causation: '''acquired''' and '''congenital'''. Research regarding the influence of preventative therapies on causation is mixed. More research is needed evaluating the role of preventative interventions, such as cholesterol lowering therapies, on the progression of disease onset.
 
==Causes==
The etiology of Left-Sided Outflow Obstruction can be divided into two broad categories:
#Acquired Aortic Stenosis and
#Congenital Left-Sided Outflow Obstruction
 
Major causes and predisposing conditions of aortic stenosis include [[acute rheumatic fever]] and [[bicuspid aortic valve]]. As individuals age, calcification of the [[aortic valve]] may occur and result in stenosis. This is especially likely to occur in people with a bicuspid aortic valve, but also occurs in the setting of perfectly normal valves as a result of age-induced 'wear and tear'. Typically, aortic stenosis due to calcification of a bicuspid valve occurs in the 4th of 5th decade of life, whereas symptomatic onset due to calcification of a normal valve tends to occur later - around the 7th or 8th decade.
 
Of the various forms of aortic stenosis, the calcific type is predominant. Since calcific aortic stenosis shares many pathological features and risk factors with [[atherosclerosis]]. As atherosclerosis may be prevented and/or reversed by cholesterol lowering, there has been interest in attempting to modify the course of calcific aortic stenosis by cholesterol lowering with [[statin]] drugs. Although a number of small, [[observational studies]] demonstrated an association between lowered cholesterol and decreased progression, and even regression, of calcific aortic stenosis. A large [[randomized clinical trial]], published in 2005, failed to find any predictable effect of cholesterol lowering on calcific aortic stenosis. Researchers in 2007 study conversely demonstrated a slowing of aortic stenosis with the statin [[rosuvastatin]].<ref>{{cite journal |author=Moura LM, Ramos SF, Zamorano JL, ''et al'' |title=Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis |journal=J. Am. Coll. Cardiol. |volume=49 |issue=5 |pages=554-61 |year=2007 |pmid=17276178 |doi=10.1016/j.jacc.2006.07.072}}</ref> More research is necessary to further clarify the specific mechanisms of disease onset and the influence of interventional methodologies on overall causation.


==Genetics==
==Genetics==
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{{reflist|2}}


{{Circulatory system pathology}}
{{Congenital malformations and deformations of circulatory system}}
[[Category:DiseaseState]]
[[Category:DiseaseState]]
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[[Category:Signs and symptoms]]
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[[Category:Cardiology]]
[[Category:Cardiology]]
[[Category:Congenital heart disease]]
[[Category:Congenital heart disease]]
[[Category:Mature chapter]]


[[de:Aortenstenose (angeboren)]]
[[es:Estenosis aórtica]]
[[es:Estenosis aórtica]]
[[fr:Rétrécissement aortique]]
[[fr:Rétrécissement aortique]]
[[no:Aortastenose]]
[[nn:Aortastenose]]
[[pl:Stenoza Aortalnej]]
[[pl:Stenoza Aortalnej]]
[[pt:Estenose aórtica]]
[[pt:Estenose aórtica]]
[[ro:Stenoza Aortică]]
[[ro:Stenoza Aortică]]
[[sv:Aortastenos]]
[[tr:Aort darlığı]]
[[tr:Aort darlığı]]


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Revision as of 14:30, 25 July 2011

Aortic Stenosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Aortic Stenosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Cardiac Stress Test

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography

Cardiac Catheterization

Aortic Valve Area

Aortic Valve Area Calculation

Treatment

General Approach

Medical Therapy

Surgery

Percutaneous Aortic Balloon Valvotomy (PABV) or Aortic Valvuloplasty

Transcatheter Aortic Valve Replacement (TAVR)

TAVR vs SAVR
Critical Pathway
Patient Selection
Imaging
Evaluation
Valve Types
TAVR Procedure
Post TAVR management
AHA/ACC Guideline Recommendations

Follow Up

Prevention

Precautions and Prophylaxis

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Aortic stenosis causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Aortic stenosis causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Aortic stenosis causes

CDC on Aortic stenosis causes

Aortic stenosis causes in the news

Blogs on Aortic stenosis causes

Directions to Hospitals Treating Aortic stenosis causes

Risk calculators and risk factors for Aortic stenosis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editors-In-Chief: Claudia P. Hochberg, M.D. [2]; Abdul-Rahman Arabi, M.D. [3]; Keri Shafer, M.D. [4]

Overview

Aortic stenosis can be categorized under two methods of causation: acquired and congenital. Research regarding the influence of preventative therapies on causation is mixed. More research is needed evaluating the role of preventative interventions, such as cholesterol lowering therapies, on the progression of disease onset.

Genetics

Congenital bicuspid valve is the most frequent form of congenital heart disease affecting approximately 1-2% of the population. 1/3rd of Supravalvular Aortic Stenosis cases are transmitted as an autosomal dominant trait as 60% of patients with supravalvular obstruction have Williams syndrome (supravalvular obstruction, intellectual impairment and facial abnormalities).

References

de:Aortenstenose (angeboren) no:Aortastenose nn:Aortastenose sv:Aortastenos

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