Retinoblastoma differential diagnosis: Difference between revisions
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Congenital Cataract | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |Congenital Cataract | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Presents at birth | *Presents at birth | ||
*Lens opacification rare in retinoblastoma | *Lens opacification rare in retinoblastoma | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
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*More common in males | *More common in males | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Fundus examination: lesion appears more yellow-colored (versus chalky white-gray in retinoblastoma); telangiectatic and aneurysmal retinal vessels are characteristic of Coats disease but uncommon in retinoblastoma | *Fundus examination: lesion appears more yellow-colored (versus chalky white-gray in retinoblastoma); telangiectatic and aneurysmal retinal vessels are characteristic of Coats disease but uncommon in retinoblastoma | ||
*Spectral domain optical coherence tomography may be helpful in distinguishing Coats disease from retinoblastoma | *Spectral domain optical coherence tomography may be helpful in distinguishing Coats disease from retinoblastoma | ||
*Ophthalmic ultrasound: can be misleading because calcification can also be seen in Coats disease | *Ophthalmic ultrasound: can be misleading because calcification can also be seen in Coats disease | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Persistent fetal vasculature (formerly known as persistent hyperplastic primary vitreous) | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Persistent fetal vasculature (formerly known as persistent hyperplastic primary vitreous) | ||
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*Dragging of the ciliary processes on exam | *Dragging of the ciliary processes on exam | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Measurement of axial length using fundus examination and ultrasound shows short axial length in persistent fetal vasculature | *Measurement of axial length using fundus examination and ultrasound shows short axial length in persistent fetal vasculature | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Retinopathy of prematurity (ROP) | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Retinopathy of prematurity (ROP) | ||
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*Can result in total retinal detachment | *Can result in total retinal detachment | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Fundus examination: reveals gliotic-appearing retina, which is different from the retinal detachment associated with retinoblastoma | *Fundus examination: reveals gliotic-appearing retina, which is different from the retinal detachment associated with retinoblastoma | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Ocular toxocariasis | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Ocular toxocariasis | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] | ||
[[Category: | [[Category:Hereditary cancers]] |
Revision as of 13:25, 19 October 2015
Retinoblastoma Microchapters |
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Retinoblastoma differential diagnosis On the Web |
American Roentgen Ray Society Images of Retinoblastoma differential diagnosis |
Risk calculators and risk factors for Retinoblastoma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Retinoblastoma must be differentiated from other diseases that cause leukocoria, such as congenital cataract, persistent fetal vasculature, Coats disease, coloboma of choroid or optic disc, toxocariasis, astrocytic hamartoma, retinopathy of prematurity, vitreous hemorrhage, uveitis, retinal dysplasia, and medulloepithelioma.[1]
Differential diagnosis
Retinoblastoma must be differentiated from other diseases that cause leukocoria. The common causes of leukocoria in children include:[1]
- Congenital cataract
- Persistent fetal vasculature
- Coats disease
Less common causes of leukocoria include:
- Coloboma of choroid or optic disc
- Toxocariasis
- Astrocytic hamartoma
- Retinopathy of prematurity (stage 4, 5)
- Vitreous hemorrhage
- Uveitis
Differentiating features of some common and less common differential diagnosis are:
Disease/Condition | Differentiating Signs/Symptoms | Differentiating Tests |
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Congenital Cataract |
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Coats disease (exudative retinitis or retinal telangiectasis) |
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Persistent fetal vasculature (formerly known as persistent hyperplastic primary vitreous) |
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Retinopathy of prematurity (ROP) |
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Ocular toxocariasis |
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References
- ↑ 1.0 1.1 Retinoblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Retinoblastoma#cite_note-30 Accessed on October 2 2015