Hereditary nonpolyposis colorectal cancer medical therapy: Difference between revisions
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{{Hereditary nonpolyposis colorectal cancer}} | {{Hereditary nonpolyposis colorectal cancer}} | ||
{{CMG}}{{AE}}{{MV}} | {{CMG}}{{AE}}{{MV}}{{Akram}} | ||
==Overview== | ==Overview== | ||
There is no medical treatment for hereditary nonpolyposis colorectal cancer. | There is no [[medical treatment]] for hereditary nonpolyposis colorectal cancer. However, hereditary nonpolyposis colorectal cancer [[Patient|patients]] should consider [[diet]] optimization and [[pharmacological]] [[Prevention (medical)|prevention]]. | ||
==Medical Therapy== | ==Medical Therapy== | ||
Patients with hereditary nonpolyposis colorectal cancer should consider the following options of medical management: | [[Patient|Patients]] with hereditary nonpolyposis colorectal cancer should consider the following options of [[Medicine|medical]] management: | ||
===Diet Optimization=== | ===Diet Optimization=== | ||
*Patients with high risk of colorectal cancer should consider a low fat diet with limitations concerning red meat.<ref>{{Cite journal | *[[Patients]] with high risk of [[colorectal cancer]] should consider a low [[fat]] [[diet]] with limitations concerning red meat.<ref>{{Cite journal | ||
| author = [[W. C. Willett]], [[M. J. Stampfer]], [[G. A. Colditz]], [[B. A. Rosner]] & [[F. E. Speizer]] | | author = [[W. C. Willett]], [[M. J. Stampfer]], [[G. A. Colditz]], [[B. A. Rosner]] & [[F. E. Speizer]] | ||
| title = Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women | | title = Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women | ||
Line 35: | Line 35: | ||
| pmid = 19804605 | | pmid = 19804605 | ||
}}</ref> | }}</ref> | ||
*Dietary approaches should consider the inclusion of high fiber and rich in cellulose foods. | *[[Dietary]] approaches should consider the inclusion of high [[fiber]] and rich in [[cellulose]] [[Food|foods]]. | ||
===Pharmacological Prevention=== | ===Pharmacological Prevention=== | ||
*Drugs lowering the risk of colorectal cancer include:<ref>{{Cite journal | *[[Drugs]] lowering the risk of [[colorectal cancer]] include:<ref>{{Cite journal | ||
| author = [[H. T. Lynch]] & [[J. Lynch]] | | author = [[H. T. Lynch]] & [[J. Lynch]] | ||
| title = Lynch syndrome: genetics, natural history, genetic counseling, and prevention | | title = Lynch syndrome: genetics, natural history, genetic counseling, and prevention | ||
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| doi = 10.1186/1897-4287-6-2-99 | | doi = 10.1186/1897-4287-6-2-99 | ||
| pmid = 19804605 | | pmid = 19804605 | ||
}}</ref> | }}</ref><ref name="pmid22036019">{{cite journal| author=Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S et al.| title=Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. | journal=Lancet | year= 2011 | volume= 378 | issue= 9809 | pages= 2081-7 | pmid=22036019 | doi=10.1016/S0140-6736(11)61049-0 | pmc=3243929 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22036019 }} </ref><ref name="pmid23639481">{{cite journal| author=Lu KH, Loose DS, Yates MS, Nogueras-Gonzalez GM, Munsell MF, Chen LM et al.| title=Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome. | journal=Cancer Prev Res (Phila) | year= 2013 | volume= 6 | issue= 8 | pages= 774-81 | pmid=23639481 | doi=10.1158/1940-6207.CAPR-13-0020 | pmc=3737517 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23639481 }} </ref> | ||
:*[[Aspirin]] | :*[[Aspirin]] | ||
:*[[Sulindac]] | :*[[Sulindac]] | ||
:*[[Calcium]] | :*[[Calcium]] | ||
:*[[Vitamin C]] | :*[[Vitamin C]] | ||
The real value of these drugs in cancer prevention in hereditary nonpolyposis colorectal | :*[[Folic acid]] | ||
:*[[Oral contraceptives]] | |||
The real value of these [[drugs]] in [[cancer]] [[prevention]] in hereditary nonpolyposis colorectal cance<nowiki/>r cannot be excluded, but is not definitely proven. Further studies are needed to find the optimal [[dosage]] and duration of [[therapy]] for these [[medications]]. | |||
==References== | ==References== |
Latest revision as of 21:43, 29 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
There is no medical treatment for hereditary nonpolyposis colorectal cancer. However, hereditary nonpolyposis colorectal cancer patients should consider diet optimization and pharmacological prevention.
Medical Therapy
Patients with hereditary nonpolyposis colorectal cancer should consider the following options of medical management:
Diet Optimization
- Patients with high risk of colorectal cancer should consider a low fat diet with limitations concerning red meat.[1][2]
- Dietary approaches should consider the inclusion of high fiber and rich in cellulose foods.
Pharmacological Prevention
The real value of these drugs in cancer prevention in hereditary nonpolyposis colorectal cancer cannot be excluded, but is not definitely proven. Further studies are needed to find the optimal dosage and duration of therapy for these medications.
References
- ↑ W. C. Willett, M. J. Stampfer, G. A. Colditz, B. A. Rosner & F. E. Speizer (1990). "Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women". The New England journal of medicine. 323 (24): 1664–1672. doi:10.1056/NEJM199012133232404. PMID 2172820. Unknown parameter
|month=
ignored (help) - ↑ Jozef Kladny & Jan Lubinski (2008). "Lynch syndrome (HNPCC)". Hereditary cancer in clinical practice. 6 (2): 99–102. doi:10.1186/1897-4287-6-2-99. PMID 19804605. Unknown parameter
|month=
ignored (help) - ↑ H. T. Lynch & J. Lynch (2000). "Lynch syndrome: genetics, natural history, genetic counseling, and prevention". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 18 (21 Suppl): 19S–31S. PMID 11060321. Unknown parameter
|month=
ignored (help) - ↑ Matthew B. Yurgelun & Heather Hampel (2018). "Recent Advances in Lynch Syndrome: Diagnosis, Treatment, and Cancer Prevention". American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting (38): 101–109. doi:10.1200/EDBK_208341. PMID 30231390. Unknown parameter
|month=
ignored (help) - ↑ Jozef Kladny & Jan Lubinski (2008). "Lynch syndrome (HNPCC)". Hereditary cancer in clinical practice. 6 (2): 99–102. doi:10.1186/1897-4287-6-2-99. PMID 19804605. Unknown parameter
|month=
ignored (help) - ↑ Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S; et al. (2011). "Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial". Lancet. 378 (9809): 2081–7. doi:10.1016/S0140-6736(11)61049-0. PMC 3243929. PMID 22036019.
- ↑ Lu KH, Loose DS, Yates MS, Nogueras-Gonzalez GM, Munsell MF, Chen LM; et al. (2013). "Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome". Cancer Prev Res (Phila). 6 (8): 774–81. doi:10.1158/1940-6207.CAPR-13-0020. PMC 3737517. PMID 23639481.