Diffuse esophageal spasm epidemiology and demographics: Difference between revisions

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{{CMG}}; {{AE}} {{MSI}}
{{CMG}}; {{AE}} {{MSI}}
==Overview==
==Overview==
DES is relatively uncommon diseasewith incidence of approx. 1 per 100,000 in the USA that can affect all age groups.
Diffuse esophageal spasm is relatively uncommon disease with incidence of 1 per 100,000 in the USA. DES affects all age groups. There is no racial predilection to DES.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
===Incidence===
*The incidence of DES is approximately 1 per 100,000 individuals in USA<ref name="pmid978">{{cite journal |vauthors=Swett C, Makar AB, McMartin KE, Palese M, Tephly TR, Bals MG, Toma E, Zelikovski A, Abu-Dalu J, Urca I, Anderson TR, Slotkin TA |title=Outpatient phenothiazine use and bone marrow depression. A report from the drug epidemiology unit and the Boston collaborative drug surveillance program |journal=Arch. Gen. Psychiatry |volume=32 |issue=11 |pages=1416–8 |year=1975 |pmid=978 |doi= |url=}}</ref>.
*The incidence of DES is approximately 1 per 100,000 individuals in USA.<ref name="pmid978">{{cite journal |vauthors=Swett C, Makar AB, McMartin KE, Palese M, Tephly TR, Bals MG, Toma E, Zelikovski A, Abu-Dalu J, Urca I, Anderson TR, Slotkin TA |title=Outpatient phenothiazine use and bone marrow depression. A report from the drug epidemiology unit and the Boston collaborative drug surveillance program |journal=Arch. Gen. Psychiatry |volume=32 |issue=11 |pages=1416–8 |year=1975 |pmid=978 |doi= |url=}}</ref>


===Prevalence===
===Prevalence===
*The prevalence of DES is 4% among patients referred for esophageal symptoms; 7% among morbidly obese patients undergoing bariatric surgery<ref name="pmid10484299">{{cite journal| author=Jaffin BW, Knoepflmacher P, Greenstein R| title=High prevalence of asymptomatic esophageal motility disorders among morbidly obese patients. | journal=Obes Surg | year= 1999 | volume= 9 | issue= 4 | pages= 390-5 | pmid=10484299 | doi=10.1381/096089299765552990 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10484299 }}</ref>, 2-7% among patients with known cardiac diseases<ref name="pmid2139562">{{cite journal| author=Hewson EG, Dalton CB, Hackshaw BT, Wu WC, Richter JE| title=The prevalence of abnormal esophageal test results in patients with cardiovascular disease and unexplained chest pain. | journal=Arch Intern Med | year= 1990 | volume= 150 | issue= 5 | pages= 965-9 | pmid=2139562 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2139562 }}</ref>.
*The prevalence of DES is 400 per 100,000 patients referred for [[esophageal]] symptoms; 7 per 100 morbidly obese patients undergoing [[bariatric surgery]], 2-7% among patients with known [[Heart disease|cardiac diseases]].<ref name="pmid2139562">{{cite journal| author=Hewson EG, Dalton CB, Hackshaw BT, Wu WC, Richter JE| title=The prevalence of abnormal esophageal test results in patients with cardiovascular disease and unexplained chest pain. | journal=Arch Intern Med | year= 1990 | volume= 150 | issue= 5 | pages= 965-9 | pmid=2139562 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2139562 }}</ref><ref name="pmid10484299">{{cite journal| author=Jaffin BW, Knoepflmacher P, Greenstein R| title=High prevalence of asymptomatic esophageal motility disorders among morbidly obese patients. | journal=Obes Surg | year= 1999 | volume= 9 | issue= 4 | pages= 390-5 | pmid=10484299 | doi=10.1381/096089299765552990 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10484299 }}</ref>
*Large series of patients undergoing esophageal motility testing for related symptoms had prevalence of DES 4-10%.<ref name="pmid21143695">{{cite journal| author=Tsuboi K, Mittal SK| title=Diffuse esophageal spasm: has the term lost its relevance? Analysis of 217 cases. | journal=Dis Esophagus | year= 2011 | volume= 24 | issue= 5 | pages= 354-9 | pmid=21143695 | doi=10.1111/j.1442-2050.2010.01146.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21143695  }}</ref>  
*Large series of patients undergoing [[Esophageal motility study|esophageal motility testing]] for related symptoms had prevalence of DES 400-1,000 per 100,000.<ref name="pmid21143695">{{cite journal| author=Tsuboi K, Mittal SK| title=Diffuse esophageal spasm: has the term lost its relevance? Analysis of 217 cases. | journal=Dis Esophagus | year= 2011 | volume= 24 | issue= 5 | pages= 354-9 | pmid=21143695 | doi=10.1111/j.1442-2050.2010.01146.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21143695  }}</ref>  


===Case-fatality rate/Mortality rate===
===Case-fatality rate/Mortality rate===
Line 18: Line 18:


===Age===
===Age===
*Patients of all age groups may develop DES, but limited study results shows more common in age group 60-80 years and the prevalence of disease increases with age.
*Patients of all age groups may develop DES, but limited study results shows more common in age group 60-80 years and the prevalence of [[disease]] increases with age.


===Race===
===Race===
*There is no racial predilection to DES.
*There is no racial predilection to DES.
===Gender===
===Gender===
*Female are more commonly affected by DES than male.  
*Females are more commonly affected by DES than male.  
 
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 20:15, 28 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]

Overview

Diffuse esophageal spasm is relatively uncommon disease with incidence of 1 per 100,000 in the USA. DES affects all age groups. There is no racial predilection to DES.

Epidemiology and Demographics

Incidence

  • The incidence of DES is approximately 1 per 100,000 individuals in USA.[1]

Prevalence

Case-fatality rate/Mortality rate

  • There are no reported cases of mortality due to DES.

Age

  • Patients of all age groups may develop DES, but limited study results shows more common in age group 60-80 years and the prevalence of disease increases with age.

Race

  • There is no racial predilection to DES.

Gender

  • Females are more commonly affected by DES than male.

References

  1. Swett C, Makar AB, McMartin KE, Palese M, Tephly TR, Bals MG, Toma E, Zelikovski A, Abu-Dalu J, Urca I, Anderson TR, Slotkin TA (1975). "Outpatient phenothiazine use and bone marrow depression. A report from the drug epidemiology unit and the Boston collaborative drug surveillance program". Arch. Gen. Psychiatry. 32 (11): 1416–8. PMID 978.
  2. Hewson EG, Dalton CB, Hackshaw BT, Wu WC, Richter JE (1990). "The prevalence of abnormal esophageal test results in patients with cardiovascular disease and unexplained chest pain". Arch Intern Med. 150 (5): 965–9. PMID 2139562.
  3. Jaffin BW, Knoepflmacher P, Greenstein R (1999). "High prevalence of asymptomatic esophageal motility disorders among morbidly obese patients". Obes Surg. 9 (4): 390–5. doi:10.1381/096089299765552990. PMID 10484299.
  4. Tsuboi K, Mittal SK (2011). "Diffuse esophageal spasm: has the term lost its relevance? Analysis of 217 cases". Dis Esophagus. 24 (5): 354–9. doi:10.1111/j.1442-2050.2010.01146.x. PMID 21143695.

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