|
|
| (112 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| __NOTOC__ | | __NOTOC__ |
| {{Infobox_Disease
| |
| | Name = Asplenia
| |
| | Image =
| |
| | Caption =
| |
| | DiseasesDB =
| |
| | ICD10 = {{ICD10|D|73|0|d|70}}, {{ICD10|Q|89|0|q|80}}
| |
| | ICD9 = {{ICD9|289.59}}, {{ICD9|759.01}}
| |
| | ICDO =
| |
| | OMIM = 208530
| |
| | OMIM_mult = {{OMIM2|%271400}} {{OMIM2|208540}}
| |
| | MedlinePlus =
| |
| | MeshID =
| |
| }}
| |
| {{Asplenia}} | | {{Asplenia}} |
| {{CMG}}{{AE}} | | {{CMG}}{{AE}} {{Kalpana Giri}} |
|
| |
|
| {{SK}} | | {{SK}} |
| Line 21: |
Line 8: |
|
| |
|
| ==[[Asplenia historical perspective|Historical Perspective]]== | | ==[[Asplenia historical perspective|Historical Perspective]]== |
| *In 1919, Morris and Bullock provided initial [[experimental]] evidence of the protective role of the [[spleen]] against [[infections]].<ref name="pmid21474172">{{cite journal| author=Di Sabatino A, Carsetti R, Corazza GR| title=Post-splenectomy and hyposplenic states. | journal=Lancet | year= 2011 | volume= 378 | issue= 9785 | pages= 86-97 | pmid=21474172 | doi=10.1016/S0140-6736(10)61493-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21474172 }} </ref>
| |
| *In 1952, King and Schumacker reported a series of cases of [[post-splenectomy]] infections (OPSI) caused by [[encapsulated bacteria]].
| |
|
| |
|
| ==[[Asplenia classification|Classification]]== | | ==[[Asplenia classification|Classification]]== |
|
| |
|
| ==[[Asplenia pathophysiology|Pathophysiology]]== | | ==[[Asplenia pathophysiology|Pathophysiology]]== |
| It is understood that [[Asplenia]] is a variety of clinical settings, and it can refer to an [[anatomic]] absence of the [[spleen]] or [[functional asplenia]] secondary to a variety of [[disease]] states. <ref name="pmid30844198">{{cite journal| author=| title=StatPearls | journal= | year= 2021 | volume= | issue= | pages= | pmid=30844198 | doi= | pmc= | url= }} </ref>
| |
|
| |
|
| ==[[Asplenia causes|Causes]]== | | ==[[Asplenia causes|Causes]]== |
| Asplenia is caused by either congenital, functional, or acquired conditions.
| |
|
| |
| *'''Congenital asplenia'''
| |
| **Is a very rare anomaly that has been reported in both infants and adults.
| |
| **'''Infantile''' cases are almost invariably associated with serious congenital malformations of the [[cardiovascular]], [[gastrointestinal]], and [[pulmonary]] systems that are not compatible with long life.
| |
| **These include [[atrioventricular]] communist, [[pulmonary stenosis]] or [[atresia]], anomalies of the [[aorta]] and [[great vessels]], complete or partial [[situs in versus]], [[anomalies]] of the [[mesenteric]] and [[accessory lobes of the lungs]].
| |
| **In the '''adult''' [[splenic]] [[agenesis]] is usually an isolated and unexpected finding.<ref name="pmid13322226">{{cite journal| author=MYERSON RM, KOELLE WA| title=Congenital absence of the spleen in an adult; report of a case associated with recurrent Waterhouse-Friderichsen syndrome. | journal=N Engl J Med | year= 1956 | volume= 254 | issue= 24 | pages= 1131-2 | pmid=13322226 | doi=10.1056/NEJM195606142542406 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13322226 }} </ref>
| |
|
| |
| *'''Acquired asplenia''' associated after trauma or surgery.<ref name="pmid26557043">{{cite journal| author=Erdem SB, Genel F, Erdur B, Ozbek E, Gulez N, Mese T| title=Asplenia in children with congenital heart disease as a cause of poor outcome. | journal=Cent Eur J Immunol | year= 2015 | volume= 40 | issue= 2 | pages= 266-9 | pmid=26557043 | doi=10.5114/ceji.2015.52841 | pmc=4637402 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26557043 }} </ref>
| |
|
| |
| *'''Functional asplenia''' include sickle cell anemia.<ref name="pmid26557043">{{cite journal| author=Erdem SB, Genel F, Erdur B, Ozbek E, Gulez N, Mese T| title=Asplenia in children with congenital heart disease as a cause of poor outcome. | journal=Cent Eur J Immunol | year= 2015 | volume= 40 | issue= 2 | pages= 266-9 | pmid=26557043 | doi=10.5114/ceji.2015.52841 | pmc=4637402 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26557043 }} </ref>
| |
|
| |
|
| ==[[Asplenia differential diagnosis|Differentiating Asplenia from other Diseases]]== | | ==[[Asplenia differential diagnosis|Differentiating Asplenia from other Diseases]]== |
| Line 56: |
Line 29: |
|
| |
|
| ==Treatment== | | ==Treatment== |
| [[Asplenia medical therapy|Medical Therapy]] | [[Asplenia interventions|Interventions]] | [[Asplenia surgery|Surgery]] | [[Asplenia primary prevention|Primary Prevention]] | [[Asplenia secondary prevention|Secondary Prevention]] | [[Asplenia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Asplenia future or investigational therapies|Future or Investigational Therapies]] | | [[Asplenia medical treatment|Medical Therapy]] | [[TAsplenia surgical techniques|Surgery]] | [[Asplenia primary prevention|Primary Prevention]] | [[Asplenia secondary prevention|Secondary Prevention]] | [[Asplenia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Asplenia future or investigational therapies|Future or Investigational Therapies]] |
| | |
| ==Case Studies== | | ==Case Studies== |
| [[Asplenia case study one|Case #1]] | | [[Asplenia case study one|Case #1]] |
|
| |
| {{Hematology}}
| |
| {{Phakomatoses and other congenital malformations not elsewhere classified}}
| |
|
| |
|
| |
| [[de:Asplenie]]
| |
| [[nl:Asplenie]]
| |
| [[fi:Asplenia]]
| |
|
| |
|
| |
| | | |
| {{WikiDoc Help Menu}} | | {{WikiDoc Help Menu}} |
| {{WikiDoc Sources}}
| |
|
| |
| [[Category:Medicine]] | | [[Category:Medicine]] |
| [[Category:Oncology]] | | [[Category:Oncology]] |