Osteochondroma classification: Difference between revisions

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==Classification==
==Classification==


The table below differentiates between the 2 subtypes of osteochondromas:<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref>  
The table below differentiates between the 2 subtypes of osteochondromas:<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref><ref name="pmid25728463">{{cite journal |vauthors=Kushner BH, Roberts SS, Friedman DN, Kuk D, Ostrovnaya I, Modak S, Kramer K, Basu EM, Cheung NK |title=Osteochondroma in long-term survivors of high-risk neuroblastoma |journal=Cancer |volume=121 |issue=12 |pages=2090–6 |date=June 2015 |pmid=25728463 |pmc=4970322 |doi=10.1002/cncr.29316 |url=}}</ref><ref name="pmid17211603">{{cite journal |vauthors=Marcovici PA, Berdon WE, Liebling MS |title=Osteochondromas and growth retardation secondary to externally or internally administered radiation in childhood |journal=Pediatr Radiol |volume=37 |issue=3 |pages=301–4 |date=March 2007 |pmid=17211603 |doi=10.1007/s00247-006-0382-0 |url=}}</ref><ref name="pmid19747635">{{cite journal |vauthors=Faraci M, Bagnasco F, Corti P, Messina C, Fagioli F, Podda M, Prete A, Caselli D, Lanino E, Dini G, Rondelli R, Haupt R |title=Osteochondroma after hematopoietic stem cell transplantation in childhood. An Italian study on behalf of the AIEOP-HSCT group |journal=Biol. Blood Marrow Transplant. |volume=15 |issue=10 |pages=1271–6 |date=October 2009 |pmid=19747635 |doi=10.1016/j.bbmt.2009.06.003 |url=}}</ref><ref name="pmid18328980">{{cite journal |vauthors=Pannier S, Legeai-Mallet L |title=Hereditary multiple exostoses and enchondromatosis |journal=Best Pract Res Clin Rheumatol |volume=22 |issue=1 |pages=45–54 |date=March 2008 |pmid=18328980 |doi=10.1016/j.berh.2007.12.004 |url=}}</ref><ref name="pmid18271966">{{cite journal |vauthors=Bovée JV |title=Multiple osteochondromas |journal=Orphanet J Rare Dis |volume=3 |issue= |pages=3 |date=February 2008 |pmid=18271966 |pmc=2276198 |doi=10.1186/1750-1172-3-3 |url=}}</ref><ref name="pmid8027127">{{cite journal |vauthors=Schmale GA, Conrad EU, Raskind WH |title=The natural history of hereditary multiple exostoses |journal=J Bone Joint Surg Am |volume=76 |issue=7 |pages=986–92 |date=July 1994 |pmid=8027127 |doi=10.2106/00004623-199407000-00005 |url=}}</ref><ref name="pmid7702095">{{cite journal |vauthors=Wicklund CL, Pauli RM, Johnston D, Hecht JT |title=Natural history study of hereditary multiple exostoses |journal=Am. J. Med. Genet. |volume=55 |issue=1 |pages=43–6 |date=January 1995 |pmid=7702095 |doi=10.1002/ajmg.1320550113 |url=}}</ref>


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Latest revision as of 01:56, 14 October 2019

Osteochondroma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas (hereditary).[1]

Classification

The table below differentiates between the 2 subtypes of osteochondromas:[1][2][3][4][5][6][7][8]

Type of Osteochondroma Features
Solitary osteochondroma
  • Non-hereditary
  • 85% of osteochondromas
  • No genetic mutations
  • Located in long bones
  • Onset is in early adolescence
Multiple osteochondromas
  • Hereditary
  • Approximately 20% of osteochondromas
  • Related genetic mutations EXT-1 and EXT-2
  • Early onset of disease (newborn or children)

References

  1. 1.0 1.1 Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M (2008). "Osteochondromas: review of the clinical, radiological and pathological features". In Vivo (Athens, Greece). 22 (5): 633–46. PMID 18853760.
  2. Kushner BH, Roberts SS, Friedman DN, Kuk D, Ostrovnaya I, Modak S, Kramer K, Basu EM, Cheung NK (June 2015). "Osteochondroma in long-term survivors of high-risk neuroblastoma". Cancer. 121 (12): 2090–6. doi:10.1002/cncr.29316. PMC 4970322. PMID 25728463.
  3. Marcovici PA, Berdon WE, Liebling MS (March 2007). "Osteochondromas and growth retardation secondary to externally or internally administered radiation in childhood". Pediatr Radiol. 37 (3): 301–4. doi:10.1007/s00247-006-0382-0. PMID 17211603.
  4. Faraci M, Bagnasco F, Corti P, Messina C, Fagioli F, Podda M, Prete A, Caselli D, Lanino E, Dini G, Rondelli R, Haupt R (October 2009). "Osteochondroma after hematopoietic stem cell transplantation in childhood. An Italian study on behalf of the AIEOP-HSCT group". Biol. Blood Marrow Transplant. 15 (10): 1271–6. doi:10.1016/j.bbmt.2009.06.003. PMID 19747635.
  5. Pannier S, Legeai-Mallet L (March 2008). "Hereditary multiple exostoses and enchondromatosis". Best Pract Res Clin Rheumatol. 22 (1): 45–54. doi:10.1016/j.berh.2007.12.004. PMID 18328980.
  6. Bovée JV (February 2008). "Multiple osteochondromas". Orphanet J Rare Dis. 3: 3. doi:10.1186/1750-1172-3-3. PMC 2276198. PMID 18271966.
  7. Schmale GA, Conrad EU, Raskind WH (July 1994). "The natural history of hereditary multiple exostoses". J Bone Joint Surg Am. 76 (7): 986–92. doi:10.2106/00004623-199407000-00005. PMID 8027127.
  8. Wicklund CL, Pauli RM, Johnston D, Hecht JT (January 1995). "Natural history study of hereditary multiple exostoses". Am. J. Med. Genet. 55 (1): 43–6. doi:10.1002/ajmg.1320550113. PMID 7702095.