Hereditary nonpolyposis colorectal cancer differential diagnosis: Difference between revisions
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[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Hereditary_nonpolyposis_colorectal_cancer]] | |||
{{CMG}}{{AE}}{{MV}}{{Akram}} | {{CMG}}{{AE}}{{MV}}{{Akram}} | ||
==Overview== | ==Overview== |
Revision as of 23:14, 8 February 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
Hereditary nonpolyposis colorectal cancer must be differentiated from other diseases that cause familial colorectal cancer, such as: juvenile polyposis, familial adenomatous polyposis, Cowden syndrome, and MYH-associated polyposis.
Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases
HNPCC must be differentiated from other diseases, such as:[1]
Diseases | History and Symptoms | Physical Examination | Laboratory Findings | Other Findings | ||||||
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Abdominal Pain | Rectal Bleeding | Fatigue | Abdominal Tenderness | Hyperpigmentation | Anemia | Gene(s) | Gastrointestinal Tumors | Cancers | ||
Hereditary Non–Polyposis Colon Cancer | – | + | + | +/– | – | + | ||||
Carney Syndrome | – | – | – | – | – | |||||
Familial Adenomatous Polyposis | + | + | + | +/– | – | + |
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Peutz–Jeghers syndrome | + | + | + | + | + | + |
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Juvenile Polyposis Syndrome | + | + | – | – | – |
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Cowden Syndrome | – | – | – | – | – |
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Differential Diagnosis | Similar Features | Differentiating Features |
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Familial adenomatous polyposis |
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Juvenile polyposis |
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Cowden syndrome |
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References
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.