Hemolytic-uremic syndrome history and symptoms: Difference between revisions

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{{HUS}}
{{HUS}}
{{CMG}}; {{AE}}
{{CMG}} {{shyam}}; {{AE}} {{S.G.}}, {{AHS}}


==Overview==
==Overview==
The majority of patients with Hemolytic Uremic Syndrome are asymptomatic. It usually start with gastrointestinal prodrome including bloody diarrhea and fever that may occur 2-7 days before the onset of renal failure. Other symptoms include nausea, vomiting, abdominal pain and swelling, decreased urination, fatigue, irritability, and swelling of body.
The majority of patients with [[Hemolytic-uremic syndrome|hemolytic uremic syndrome]] ([[Hemolytic-uremic syndrome|HUS]]) are [[asymptomatic]]. It usually start with [[gastrointestinal]] [[prodrome]] including [[bloody diarrhea]] and [[fever]] that may occur 2-7 days before the onset of [[renal failure]]. Other [[Symptom|symptoms]] include [[nausea]], [[vomiting]], [[abdominal pain]] and [[swelling]], decreased [[urination]], [[fatigue]], [[irritability]], and [[swelling]] of body.


==History and Symptoms==
==History and Symptoms==
*The hallmark of HUS is bloody [[diarrhea]] ([[Dysentery|dysentery )]].<ref>{{Cite journal
*The [[hallmark]] of [[Hemolytic-uremic syndrome|HUS]] is [[Diarrhea with blood|bloody diarrhea]] [[Dysentery|(dysentery)]].<ref>{{Cite journal
  | author = [[R. Bhimma]], [[N. C. Rollins]], [[H. M. Coovadia]] & [[M. Adhikari]]
  | author = [[R. Bhimma]], [[N. C. Rollins]], [[H. M. Coovadia]] & [[M. Adhikari]]
  | title = Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal
  | title = Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal
Line 18: Line 18:
  | pmid = 9323280
  | pmid = 9323280
}}</ref>
}}</ref>
*A positive history of bloody [[diarrhea]] and [[Abdomen|abdominal]] [[tenderness]] is suggestive of HUS. The most common symptoms of HUS include [[bloody diarrhea,]] fever and [[gastrointestinal]] complaints .
*A positive history of [[Diarrhea with blood|bloody diarrhea]] and [[Abdomen|abdominal]] [[tenderness]] is suggestive of [[HUS]]. The most common [[Symptom|symptoms]] of [[HUS]] include [[Diarrhea with blood|bloody diarrhea]] , [[fever]] and [[gastrointestinal]] complaints. The classic triad of signs/symptoms involves microangiopathic hemolytic anemia, renal failure, and thrombocytopenia.
===Common Symptoms===
===Common Symptoms===
symptoms of [disease] include:<ref name=":0">{{Cite journal
Symptoms of [[HUS]] include:<ref name=":0">{{Cite journal
  | author = [[T. G. Boyce]], [[D. L. Swerdlow]] & [[P. M. Griffin]]
  | author = [[T. G. Boyce]], [[D. L. Swerdlow]] & [[P. M. Griffin]]
  | title = Escherichia coli O157:H7 and the hemolytic-uremic syndrome
  | title = Escherichia coli O157:H7 and the hemolytic-uremic syndrome
Line 31: Line 31:
  | doi = 10.1056/NEJM199508103330608
  | doi = 10.1056/NEJM199508103330608
  | pmid = 7609755
  | pmid = 7609755
}}</ref><ref name="pmid9092315">{{cite journal |vauthors=Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM |title=Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features |journal=Ann. Intern. Med. |volume=126 |issue=7 |pages=505–13 |date=April 1997 |pmid=9092315 |doi= |url=}}</ref> <ref>{{Cite journal
}}</ref><ref name="pmid9092315">{{cite journal |vauthors=Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM |title=Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features |journal=Ann. Intern. Med. |volume=126 |issue=7 |pages=505–13 |date=April 1997 |pmid=9092315 |doi= |url=}}</ref><ref>{{Cite journal
  | author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]]
  | author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]]
  | title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
  | title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
Line 42: Line 42:
  | doi = 10.1016/S0140-6736(05)71144-2
  | doi = 10.1016/S0140-6736(05)71144-2
  | pmid = 15781103
  | pmid = 15781103
}}</ref> <ref>{{Cite journal
}}</ref><ref>{{Cite journal
  | author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]]
  | author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]]
  | title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
  | title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
Line 53: Line 53:
  | doi = 10.1016/S0140-6736(05)71144-2
  | doi = 10.1016/S0140-6736(05)71144-2
  | pmid = 15781103
  | pmid = 15781103
}}</ref> <ref>{{Cite journal
}}</ref><ref>{{Cite journal
  | author = [[James B. Kaper]] & [[Alison D. O'Brien]]
  | author = [[James B. Kaper]] & [[Alison D. O'Brien]]
  | title = Overview and Historical Perspectives
  | title = Overview and Historical Perspectives
Line 64: Line 64:
  | pmid = 25590020
  | pmid = 25590020
}}</ref>
}}</ref>
* Bloody [[Diarrhea with blood|diarrhe]]<nowiki/>a
*<nowiki/><nowiki/><nowiki/>[[Diarrhea with blood|Bloody diarrhe]]<nowiki/>[[Diarrhea with blood|a]]
 
*<nowiki/>[[Abdominal pain]]
*Abdominal pain
*Decreased [[urination]] or [[blood]] in [[urine]]
*Decreased urination or blood in urine
*[[Vomiting]]
*[[vomiting]]
*[[Fatigue]]
*[[fatigue]]
*[[Irritability]]
*[[irritability]]
*[[Abdominal]] [[swelling]]
*Abdominal [[swelling]]
*<nowiki/>[[Blood in the urine]] ([[hematuria]])
*<nowiki/>Blood in the urine ([[hematuria]] )


===Less Common Symptoms===
===Less Common Symptoms===
Less common symptoms of HUS include:  
Less common [[symptoms]] of [[Hemolytic-uremic syndrome|HUS]] include:  
*[[Swollen face]]
*[[Swollen face]]
*[[Swollen limbs]]
*[[Swollen face|Swollen]]  [[Swollen limbs|limbs]]
*[[Seizure|Seizures]]
*[[Seizure|Seizures]]


Latest revision as of 00:33, 21 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3], Anila Hussain, MD [4]

Overview

The majority of patients with hemolytic uremic syndrome (HUS) are asymptomatic. It usually start with gastrointestinal prodrome including bloody diarrhea and fever that may occur 2-7 days before the onset of renal failure. Other symptoms include nausea, vomiting, abdominal pain and swelling, decreased urination, fatigue, irritability, and swelling of body.

History and Symptoms

Common Symptoms

Symptoms of HUS include:[2][3][4][5][6]

Less Common Symptoms

Less common symptoms of HUS include:

References

  1. ↑ R. Bhimma, N. C. Rollins, H. M. Coovadia & M. Adhikari (1997). "Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal". Pediatric nephrology (Berlin, Germany). 11 (5): 560–564. PMID 9323280. Unknown parameter |month= ignored (help)
  2. ↑ T. G. Boyce, D. L. Swerdlow & P. M. Griffin (1995). "Escherichia coli O157:H7 and the hemolytic-uremic syndrome". The New England journal of medicine. 333 (6): 364–368. doi:10.1056/NEJM199508103330608. PMID 7609755. Unknown parameter |month= ignored (help)
  3. ↑ Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM (April 1997). "Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features". Ann. Intern. Med. 126 (7): 505–13. PMID 9092315.
  4. ↑ Phillip I. Tarr, Carrie A. Gordon & Wayne L. Chandler (2005). "Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome". Lancet (London, England). 365 (9464): 1073–1086. doi:10.1016/S0140-6736(05)71144-2. PMID 15781103. Unknown parameter |month= ignored (help)
  5. ↑ Phillip I. Tarr, Carrie A. Gordon & Wayne L. Chandler (2005). "Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome". Lancet (London, England). 365 (9464): 1073–1086. doi:10.1016/S0140-6736(05)71144-2. PMID 15781103. Unknown parameter |month= ignored (help)
  6. ↑ James B. Kaper & Alison D. O'Brien (2014). "Overview and Historical Perspectives". Microbiology spectrum. 2 (6). doi:10.1128/microbiolspec.EHEC-0028-2014. PMID 25590020. Unknown parameter |month= ignored (help)

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