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==Historical Perspective==
==Historical Perspective==
*1814, George Maton, first recognized that a mild illness characterized by rash, adenopathy, and little or no fever.<ref name="pmid3890105">{{cite journal| author=Cooper LZ| title=The history and medical consequences of rubella. | journal=Rev Infect Dis | year= 1985 | volume= 7 Suppl 1 | issue=  | pages= S2-10 | pmid=3890105 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3890105  }} </ref>
*In 1866, Henry Veale named the disease rubella.<ref name="pmid3890105">{{cite journal| author=Cooper LZ| title=The history and medical consequences of rubella. | journal=Rev Infect Dis | year= 1985 | volume= 7 Suppl 1 | issue=  | pages= S2-10 | pmid=3890105 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3890105  }} </ref>
*In 1942, Norman Gregg reported the birth defects in a pregnant woman infected with rubella in the first trimester.<ref name="pmid3890105">{{cite journal| author=Cooper LZ| title=The history and medical consequences of rubella. | journal=Rev Infect Dis | year= 1985 | volume= 7 Suppl 1 | issue=  | pages= S2-10 | pmid=3890105 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3890105  }} </ref>
*Rubella is also known as German measles because the disease was first described by German physicians in the mid-eighteenth century.<ref name="pmid3535122">{{cite journal| author=Horstmann DM| title=The rubella story, 1881-1985. | journal=S Afr Med J | year= 1986 | volume= Suppl | issue=  | pages= 60-3 | pmid=3535122 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3535122  }} </ref>
*Rubella is also known as German measles because the disease was first described by German physicians in the mid-eighteenth century.<ref name="pmid3535122">{{cite journal| author=Horstmann DM| title=The rubella story, 1881-1985. | journal=S Afr Med J | year= 1986 | volume= Suppl | issue=  | pages= 60-3 | pmid=3535122 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3535122  }} </ref>
*In 1962, rubella virus was isolated in tissue culture.<ref name="pmid3890105">{{cite journal| author=Cooper LZ| title=The history and medical consequences of rubella. | journal=Rev Infect Dis | year= 1985 | volume= 7 Suppl 1 | issue=  | pages= S2-10 | pmid=3890105 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3890105  }} </ref>
*In 1972, there was an rubella epidemic in Isreal, affecting 11.8 per thousand live births.<ref name="pmid23682420">{{cite journal| author=Swartz TA, Praiss I, Isacson M, Nishmi M, Ben-Porath E, Hornstein L| title=Early results of an extensive rubella epidemic. | journal=Int J Epidemiol | year= 1975 | volume= 4 | issue= 4 | pages= 331-5 | pmid=23682420 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23682420  }} </ref><ref name="pmid6662676">{{cite journal| author=Brand N, Legum S, Saunders J, Fogel A| title=Congenital rubella in Israel following the 1978-79 rubella epidemic. | journal=Isr J Med Sci | year= 1983 | volume= 19 | issue= 10 | pages= 925-8 | pmid=6662676 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6662676  }} </ref>
*In May 2012, 194 countries at the World Health Assembly adopted the Global Vaccine Action Plan to eliminate measles and rubella in at least five WHO regions by the end of 2020. 53 member states of the WHO region still did not reach the goal for elimination of rubella to date.<ref name="pmid28412385">{{cite journal| author=Allerberger F| title=Eliminating measles and rubella in Europe. | journal=Clin Microbiol Infect | year= 2017 | volume=  | issue=  | pages=  | pmid=28412385 | doi=10.1016/j.cmi.2017.04.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28412385  }} </ref><ref name="pmid4892774">{{cite journal| author=Forbes JA| title=Rubella: historical aspects. | journal=Am J Dis Child | year= 1969 | volume= 118 | issue= 1 | pages= 5-11 | pmid=4892774 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4892774  }} </ref>
*In May 2012, 194 countries at the World Health Assembly adopted the Global Vaccine Action Plan to eliminate measles and rubella in at least five WHO regions by the end of 2020. 53 member states of the WHO region still did not reach the goal for elimination of rubella to date.<ref name="pmid28412385">{{cite journal| author=Allerberger F| title=Eliminating measles and rubella in Europe. | journal=Clin Microbiol Infect | year= 2017 | volume=  | issue=  | pages=  | pmid=28412385 | doi=10.1016/j.cmi.2017.04.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28412385  }} </ref><ref name="pmid4892774">{{cite journal| author=Forbes JA| title=Rubella: historical aspects. | journal=Am J Dis Child | year= 1969 | volume= 118 | issue= 1 | pages= 5-11 | pmid=4892774 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4892774  }} </ref>
*In 1972, there was an rubella epidemic in Isreal, affecting 11.8 per thousand live births.<ref name="pmid23682420">{{cite journal| author=Swartz TA, Praiss I, Isacson M, Nishmi M, Ben-Porath E, Hornstein L| title=Early results of an extensive rubella epidemic. | journal=Int J Epidemiol | year= 1975 | volume= 4 | issue= 4 | pages= 331-5 | pmid=23682420 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23682420  }} </ref><ref name="pmid6662676">{{cite journal| author=Brand N, Legum S, Saunders J, Fogel A| title=Congenital rubella in Israel following the 1978-79 rubella epidemic. | journal=Isr J Med Sci | year= 1983 | volume= 19 | issue= 10 | pages= 925-8 | pmid=6662676 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6662676  }} </ref>
<ref name="pmid5581012">{{cite journal
===Background===
Rubella, commonly known as German measles, is a [[disease]] caused by Rubella virus. The name is derived from the Latin, meaning ''little red''. Rubella is also known as German measles because the disease was first described by German physicians in the mid-eighteenth century. This disease is often mild and attacks often pass unnoticed. The disease can last one to five days. Children recover more quickly than adults. Infection of the mother by Rubella virus during pregnancy can be serious; if the mother is infected within the first 20 weeks of pregnancy, the child may be born with [[congenital rubella syndrome]] (CRS), which is a range of serious incurable illnesses. Spontaneous abortion occurs in up to 20% of cases.<ref name="pmid5581012">{{cite journal
|author=Siegel M, Fuerst HT, Guinee VF
|author=Siegel M, Fuerst HT, Guinee VF
|title=Rubella epidemicity and embryopathy. Results of a long-term prospective study
|title=Rubella epidemicity and embryopathy. Results of a long-term prospective study
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|pmid=5581012
|pmid=5581012
|doi=
|doi=
}}</ref><ref name="Shapiro1965">{{cite journal|last1=Shapiro|first1=Lewis|title=The Numbered Diseases: First Through Sixth|journal=JAMA: The Journal of the American Medical Association|volume=194|issue=6|year=1965|pages=680|issn=0098-7484|doi=10.1001/jama.1965.03090190102038}}</ref>
}}</ref><ref name="Shapiro1965">{{cite journal|last1=Shapiro|first1=Lewis|title=The Numbered Diseases: First Through Sixth|journal=JAMA: The Journal of the American Medical Association|volume=194|issue=6|year=1965|pages=680|issn=0098-7484|doi=10.1001/jama.1965.03090190102038}}</ref><ref name="pmid11332662">{{cite journal
 
 
Rubella is a common childhood infection usually with minimal systemic upset although transient [[arthropathy]] may occur in adults. Serious complications are very rare. If it were not for the effects of transplacental infection on the developing foetus, rubella is a relatively trivial infection.
 
Acquired, (i.e. not congenital), rubella is transmitted via airborne droplet emission from the upper respiratory tract of active cases. The virus may also be present in the urine, feces and on the skin. There is no carrier state: the reservoir exists entirely in active human cases. The disease has an [[incubation period]] of 2 to 3 weeks.<ref name="pmid11332662">{{cite journal
|author=Richardson M, Elliman D, Maguire H, Simpson J, Nicoll A
|author=Richardson M, Elliman D, Maguire H, Simpson J, Nicoll A
|title=Evidence base of incubation periods, periods of infectiousness and exclusion policies for the control of communicable diseases in schools and preschools
|title=Evidence base of incubation periods, periods of infectiousness and exclusion policies for the control of communicable diseases in schools and preschools
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|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0891-3668&volume=20&issue=4&spage=380
|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0891-3668&volume=20&issue=4&spage=380
}}</ref>
}}</ref>
In most people the virus is rapidly eliminated however, it may persist for some months post partum in infants surviving the CRS. These children were an important source of infection to other infants and, more importantly, pregnant female contacts.
===Rubella umbrella campaign===
===Rubella umbrella campaign===
The “rubella umbrella” campaign urged parents to have their children immunized from this viral infection. Rubella, or more commonly referred to as the German measles, is a mild childhood illness that can pose a serious threat to a fetus, if the mother contracts the illness during pregnancy. More than 20,000 babies were born with congenital rubella syndrome (CRS) during an outbreak of rubella in 1964-65. This epidemic cost the country an estimated $1.5 billion. The rubella vaccine was first licensed in the U.S. in 1969.
The “rubella umbrella” campaign urged parents to have their children immunized from this viral infection. Rubella, or more commonly referred to as the German measles, is a mild childhood illness that can pose a serious threat to a fetus, if the mother contracts the illness during pregnancy. More than 20,000 babies were born with congenital rubella syndrome (CRS) during an outbreak of rubella in 1964-65. This epidemic cost the country an estimated $1.5 billion. The rubella vaccine was first licensed in the U.S. in 1969.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Historical Perspective

  • 1814, George Maton, first recognized that a mild illness characterized by rash, adenopathy, and little or no fever.[1]
  • In 1866, Henry Veale named the disease rubella.[1]
  • In 1942, Norman Gregg reported the birth defects in a pregnant woman infected with rubella in the first trimester.[1]
  • Rubella is also known as German measles because the disease was first described by German physicians in the mid-eighteenth century.[2]
  • In 1962, rubella virus was isolated in tissue culture.[1]
  • In 1972, there was an rubella epidemic in Isreal, affecting 11.8 per thousand live births.[3][4]
  • In May 2012, 194 countries at the World Health Assembly adopted the Global Vaccine Action Plan to eliminate measles and rubella in at least five WHO regions by the end of 2020. 53 member states of the WHO region still did not reach the goal for elimination of rubella to date.[5][6]

[7][8][9]

Rubella umbrella campaign

The “rubella umbrella” campaign urged parents to have their children immunized from this viral infection. Rubella, or more commonly referred to as the German measles, is a mild childhood illness that can pose a serious threat to a fetus, if the mother contracts the illness during pregnancy. More than 20,000 babies were born with congenital rubella syndrome (CRS) during an outbreak of rubella in 1964-65. This epidemic cost the country an estimated $1.5 billion. The rubella vaccine was first licensed in the U.S. in 1969.

References

  1. 1.0 1.1 1.2 1.3 Cooper LZ (1985). "The history and medical consequences of rubella". Rev Infect Dis. 7 Suppl 1: S2–10. PMID 3890105.
  2. Horstmann DM (1986). "The rubella story, 1881-1985". S Afr Med J. Suppl: 60–3. PMID 3535122.
  3. Swartz TA, Praiss I, Isacson M, Nishmi M, Ben-Porath E, Hornstein L (1975). "Early results of an extensive rubella epidemic". Int J Epidemiol. 4 (4): 331–5. PMID 23682420.
  4. Brand N, Legum S, Saunders J, Fogel A (1983). "Congenital rubella in Israel following the 1978-79 rubella epidemic". Isr J Med Sci. 19 (10): 925–8. PMID 6662676.
  5. Allerberger F (2017). "Eliminating measles and rubella in Europe". Clin Microbiol Infect. doi:10.1016/j.cmi.2017.04.008. PMID 28412385.
  6. Forbes JA (1969). "Rubella: historical aspects". Am J Dis Child. 118 (1): 5–11. PMID 4892774.
  7. Siegel M, Fuerst HT, Guinee VF (1971). "Rubella epidemicity and embryopathy. Results of a long-term prospective study". Am. J. Dis. Child. 121 (6): 469–73. PMID 5581012.
  8. Shapiro, Lewis (1965). "The Numbered Diseases: First Through Sixth". JAMA: The Journal of the American Medical Association. 194 (6): 680. doi:10.1001/jama.1965.03090190102038. ISSN 0098-7484.
  9. Richardson M, Elliman D, Maguire H, Simpson J, Nicoll A (2001). "Evidence base of incubation periods, periods of infectiousness and exclusion policies for the control of communicable diseases in schools and preschools". Pediatr. Infect. Dis. J. 20 (4): 380–91. PMID 11332662.

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