TTLL3

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Tubulin tyrosine ligase-like family, member 3 is a protein that in humans is encoded by the TTLL3 gene.

Model organisms

Ttll3 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Brain histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of TTLL3 function. A conditional knockout mouse line, called Ttll3^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice but no significant abnormalities were observed.

Further reading

• Trichet, V.; Ruault, M.; Roizès, G.; De Sario, A. (2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–117. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.
• Rogowski, K.; Juge, F. O.; Van Dijk, J.; Wloga, D.; Strub, J. M.; Levilliers, N.; Thomas, D.; Bré, M. H. L. N.; Van Dorsselaer, A.; Gaertig, J.; Janke, C. (2009). "Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation". Cell. 137 (6): 1076–1087. doi:10.1016/j.cell.2009.05.020. PMID 19524510.