T-cell lymphoma

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]

T-cell lymphoma Microchapters

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Overview

Classification

Lymphoblastic lymphoma
T-cell prolymphocytic leukemia
T-cell granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK cells
Aggressive NK-cell leukemia
Adult T-cell leukemia/lymphoma
Enteropathy-type intestinal T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma

Overview

T-cell lymphoma describes several different types of Non-Hodgkin lymphoma affecting T cells or Natural killer cells (NK-cells), also known as a NK/T-cell lymphoma. Any organ that has lymphatic tissue may develop a lymphoma, including the spleen, thymus, adenoids, tonsils, digestive tract and bone marrow. Characteristically, they may present as fast (aggressive) or slow (indolent) growing lymphomas.

Lymphomas are named after the precursor cell from which it developed. A peripheral T-cell lymphomas include lymphomas which arise from mature T-cells (after maturation in the thymus), in contrast with immature T-cell lymphomas, the lymphoblastic lymphoma.

Classification

T-cell lymphomas may be classified according to updated WHO classification into 2 subtypes:[1]

Updated WHO classification of Non-Hodgkin lymphoma
T-cell and putative NK-cell neoplasms
Precursor T-cell neoplasm
Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Peripheral T-cell and NK-cell neoplasms
T-cell prolymphocytic leukemia
T-cell granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK cells
Aggressive NK-cell leukemia
Systemic EBV positive T-cell lymphoma of childhood
Hydroa vacciniforme like lymphoproliferative disorder
Adult T-cell leukemia/lymphoma
Extranodal T/NK-cell lymphoma, nasal type
Enteropathy associated intestinal T-cell lymphoma
Monomorphic epitheliotropic intestinal T-cell lymphoma
Indolent T-cell lymphoproliferative disorder of the GI tract
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Primary cutaneous CD30 T-cell lymphoproliferative disorders
  • Lymphomatoid papulosis
  • Primary cutaneous anaplastic large cell lymphoma
Primary cutaneous gamma delta T-cell lymphoma

Primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma

Primary cutaneous acral CD8 T-cell lymphoma

Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder

Peripheral T-cell lymphoma, NOS *

Peripheral T-cell lymphoma, not otherwise characterized

Angioimmunoblastic T-cell lymphoma
Follicular T-cell lymphoma
Nodal peripheral T-cell lymphoma with TFH phenotype
Anaplastic large cell lymphoma
  • ALK positive
  • ALK negitive
Breast implant associated anaplastic large-cell lymphoma

References

  1. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.

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