Streptococcus mutans

Jump to: navigation, search
Streptococcus mutans
Gram stain of S. mutans in thioglycollate broth culture.
Gram stain of S. mutans in thioglycollate broth culture.
Scientific classification
Kingdom: Bacteria
Phylum: Firmicutes
Class: Cocci
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: S. mutans
Binomial name
Streptococcus mutans
Clarke 1924

WikiDoc Resources for Streptococcus mutans

Articles

Most recent articles on Streptococcus mutans

Most cited articles on Streptococcus mutans

Review articles on Streptococcus mutans

Articles on Streptococcus mutans in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Streptococcus mutans

Images of Streptococcus mutans

Photos of Streptococcus mutans

Podcasts & MP3s on Streptococcus mutans

Videos on Streptococcus mutans

Evidence Based Medicine

Cochrane Collaboration on Streptococcus mutans

Bandolier on Streptococcus mutans

TRIP on Streptococcus mutans

Clinical Trials

Ongoing Trials on Streptococcus mutans at Clinical Trials.gov

Trial results on Streptococcus mutans

Clinical Trials on Streptococcus mutans at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Streptococcus mutans

NICE Guidance on Streptococcus mutans

NHS PRODIGY Guidance

FDA on Streptococcus mutans

CDC on Streptococcus mutans

Books

Books on Streptococcus mutans

News

Streptococcus mutans in the news

Be alerted to news on Streptococcus mutans

News trends on Streptococcus mutans

Commentary

Blogs on Streptococcus mutans

Definitions

Definitions of Streptococcus mutans

Patient Resources / Community

Patient resources on Streptococcus mutans

Discussion groups on Streptococcus mutans

Patient Handouts on Streptococcus mutans

Directions to Hospitals Treating Streptococcus mutans

Risk calculators and risk factors for Streptococcus mutans

Healthcare Provider Resources

Symptoms of Streptococcus mutans

Causes & Risk Factors for Streptococcus mutans

Diagnostic studies for Streptococcus mutans

Treatment of Streptococcus mutans

Continuing Medical Education (CME)

CME Programs on Streptococcus mutans

International

Streptococcus mutans en Espanol

Streptococcus mutans en Francais

Business

Streptococcus mutans in the Marketplace

Patents on Streptococcus mutans

Experimental / Informatics

List of terms related to Streptococcus mutans


Overview

Streptococcus mutans is a Gram-positive, facultatively anaerobic bacteria commonly found in the human oral cavity and is a significant contributor to tooth decay.[1][2] The microbe was first described by Clarke in 1924.[3]

Role in tooth decay

Along with S. sobrinus, S. mutans plays a major role in tooth decay, metabolizing sucrose to lactic acid.[2] The acidic environment created in the mouth by this process is what causes the highly mineralized tooth enamel to be vulnerable to decay. S. mutans is one of a few specialized organisms equipped with receptors for adhesion to the surface of teeth. Sucrose is utilized by S. mutans to produce a sticky, extracellular, dextran-based polysaccharide that allows them to each other forming plaque. S. mutans produces dextran via the enzyme dextransucrase (a hexosyltransferase) using sucrose as a substrate in the following reaction:

n sucrose → (glucose)n + n fructose

Sucrose is the only sugar that S. mutans can use to form this sticky polysaccharide.[1]

Conversely, many other sugars—glucose, fructose, lactose—can be digested by S. mutans, but they produce lactic acid as an end product. It is the combination of plaque and acid that leads to dental decay.[4] Due to the role the S. mutans plays in tooth decay, there have been many attempts to make a vaccine for the organism. So far, such vaccines have not been successful in humans.[5]

See also

References

  1. 1.0 1.1 Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0-8385-8529-9.
  2. 2.0 2.1 Loesche WJ (1996). Microbiology of Dental Decay and Periodontal Disease. In: Baron's Medical Microbiology (Baron S et al, eds.) (4th ed. ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
  3. Clarke, JK (1924). "On the bacterial factor in the etiology of dental caries". Brit J Exp Pathol. 5: 141&ndash, 7.
  4. Madigan M; Martinko J (editors). (2005). Brock Biology of Microorganisms (11th ed. ed.). Prentice Hall. ISBN 0-13-144329-1.
  5. Klein, J.P. (1998). "Recent Advances in the Development of a Streptococcus mutans Vaccine". European Journal of Epidemiology. 4 (4): 419–425. Retrieved 2007-05-15. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)

External links

de:Streptococcus mutans nl:Streptococcus mutans



Linked-in.jpg