Sepsis definitions
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Sepsis currently has differing definitions as shown in the table below. These definitions were compiled from the three following sources:
1) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock (2016)
2) Center of Medicare and Medicaid Services (CMS) (2015/2016)
3) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) from 2016
| Sepsis | Severe Sepsis | Septic Shock | |
|---|---|---|---|
| Surviving Sepsis
Campaign |
Life-threatening organ dysfunction caused by a dysregulated host response to infection | Not defined | A subset of sepsis with circulatory and cellular/metabolic dysfunction associated with a higher risk of mortality |
| Center of Medicare and
Medicaid Services |
Both of the following:
1) 2 or more SIRS criteria 2) Known/suspected source of infection |
Sepsis + end organ dysfunction
(See CMS Sepsis Core Measure Algorithm) |
Severe Sepsis + Lactate level greater than/equal to 4 mmol/L OR hypotension in the first hour after completion of a 30 ml/kg bolus |
| Sepsis-3 | Acute change in greater than/equal to 2 SOFA criteria secondary to an infection | Not defined | Requirement of vasopressors to maintain MAP > 65 mmHg and serum lactate > 2 mmol/L in the absence of hypovolemia |
This table is based on the 2019 published table by the Wisconsin Chapter of American College of Emergency Physicians.
See also
External links
- Surviving Sepsis Campaign
- Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
References